Project measure / variable:   GMC07   response_2

ID, description, units MPD:55622   response_2   type of response to hot plate, second reaction (0=no reaction, 1=shake, 2=lick, 3=jump, 4=other)   [designation]  
Data set, strains GMC07   inbred w/CC8   8 strains     sex: both     age: 11-12wks
Procedure nociception assay
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  STRAIN COMPARISON PLOT
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GMC07 - type of response to hot plate, second reaction (0=no reaction, 1=shake, 2=lick, 3=jump, 4=other)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means1.43   designation 1.30   designation
Median of the strain means1.47   designation 1.27   designation
SD of the strain means± 0.356 ± 0.509
Coefficient of variation (CV)0.248 0.392
Min–max range of strain means0.875   –   1.82   designation 0.500   –   2.00   designation
Mean sample size per strain17.5   mice 16.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.4869 1.4869 1.9891 0.1596
strain 7 43.4391 6.2056 8.3014 < 0.0001
sex:strain 7 2.5392 0.3627 0.4852 0.845
Residuals 259 193.6111 0.7475


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.875 1.02   16 0.256 1.17 -1.57
129S1/SvImJ m 0.5 0.894   16 0.224 1.79 -1.57
A/J f 1.25 1.0   16 0.25 0.8 -0.51
A/J m 1.25 1.0   16 0.25 0.8 -0.09
C57BL/6J f 1.81 0.544   16 0.136 0.3 1.06
C57BL/6J m 1.88 0.342   16 0.0854 0.182 1.0, 2.0 1.15
CAST/EiJ f 1.37 0.895   19 0.205 0.654 -0.17
CAST/EiJ m 1.29 0.985   17 0.239 0.761 -0.01
NOD/ShiLtJ f 1.72 0.669   18 0.158 0.389 0.81
NOD/ShiLtJ m 1.5 0.894   16 0.224 0.596 0.4
NZO/HlLtJ f 1.82 0.393   17 0.0953 0.215 1.0, 2.0 1.09
NZO/HlLtJ m 2.0 0.0   17 0.0 0.0 2.0, 2.0 1.38
PWK/PhJ f 1.05 1.19   20 0.266 1.13 -1.07
PWK/PhJ m 0.762 0.995   21 0.217 1.31 -1.05
WSB/EiJ f 1.56 0.856   18 0.202 0.55 0.36
WSB/EiJ m 1.19 1.11   16 0.277 0.934 -0.21


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.875 0.2162 1.3006 0.4494
129S1/SvImJ m 0.5 0.2162 0.9256 0.0744
A/J f 1.25 0.2162 1.6756 0.8244
A/J m 1.25 0.2162 1.6756 0.8244
C57BL/6J f 1.8125 0.2162 2.2381 1.3869
C57BL/6J m 1.875 0.2162 2.3006 1.4494
CAST/EiJ f 1.3684 0.1984 1.759 0.9778
CAST/EiJ m 1.2941 0.2097 1.707 0.8812
NOD/ShiLtJ f 1.7222 0.2038 2.1235 1.3209
NOD/ShiLtJ m 1.5 0.2162 1.9256 1.0744
NZO/HlLtJ f 1.8235 0.2097 2.2365 1.4106
NZO/HlLtJ m 2.0 0.2097 2.4129 1.5871
PWK/PhJ f 1.05 0.1933 1.4307 0.6693
PWK/PhJ m 0.7619 0.1887 1.1334 0.3904
WSB/EiJ f 1.5556 0.2038 1.9568 1.1543
WSB/EiJ m 1.1875 0.2162 1.6131 0.7619


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.6875 0.1528 0.9885 0.3865
A/J both 1.25 0.1528 1.551 0.949
C57BL/6J both 1.8437 0.1528 2.1447 1.5428
CAST/EiJ both 1.3313 0.1443 1.6155 1.0471
NOD/ShiLtJ both 1.6111 0.1485 1.9036 1.3186
NZO/HlLtJ both 1.9118 0.1483 2.2037 1.6198
PWK/PhJ both 0.906 0.1351 1.1719 0.64
WSB/EiJ both 1.3715 0.1485 1.664 1.079




  GWAS USING LINEAR MIXED MODELS