Project measure / variable:   GMC05   PPI_67

ID, description, units MPD:55431   PPI_67   percent prepulse inhibition (PPI), 110 db sound pressure level   [%]  with 67 dB prepulse stimulus  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
Ontology mappings

  STRAIN COMPARISON PLOT
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GMC05 - percent prepulse inhibition (PPI), 110 db sound pressure level with 67 dB prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means30.5   % 27.5   %
Median of the strain means29.0   % 27.5   %
SD of the strain means± 24.0 ± 18.1
Coefficient of variation (CV)0.786 0.659
Min–max range of strain means-9.31   –   69.6   % -1.10   –   50.9   %
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 773.3176 773.3176 1.3609 0.2445
strain 7 83983.617 11997.6596 21.1131 < 0.0001
sex:strain 7 19129.5145 2732.7878 4.8091 < 0.0001
Residuals 261 148315.1309 568.2572


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 69.6 14.0   16 3.51 0.201 39.1, 91.3 1.63
129S1/SvImJ m 50.9 14.4   16 3.6 0.283 25.5, 75.9 1.29
A/J f -9.31 39.6   16 9.9 -4.26 -68.4, 53.0 -1.66
A/J m 14.0 26.0   16 6.49 1.85 -52.5, 50.9 -0.74
C57BL/6J f 48.7 12.9   16 3.23 0.266 16.0, 69.7 0.76
C57BL/6J m 45.1 10.0   16 2.5 0.222 31.0, 63.2 0.97
CAST/EiJ f 43.5 13.7   19 3.15 0.316 22.5, 67.8 0.54
CAST/EiJ m 37.3 19.2   18 4.53 0.515 -4.7, 70.3 0.54
NOD/ShiLtJ f 28.8 17.5   18 4.12 0.606 -3.8, 53.3 -0.07
NOD/ShiLtJ m -1.1 21.7   16 5.41 -19.7 -58.3, 47.2 -1.58
NZO/HlLtJ f 13.0 19.6   17 4.75 1.51 -23.2, 43.5 -0.73
NZO/HlLtJ m 17.7 24.0   17 5.83 1.36 -11.3, 56.6 -0.54
PWK/PhJ f 29.2 21.8   20 4.87 0.747 -33.2, 57.9 -0.05
PWK/PhJ m 16.9 19.4   22 4.13 1.14 -22.8, 51.0 -0.58
WSB/EiJ f 20.6 49.0   18 11.6 2.38 -85.8, 63.0 -0.41
WSB/EiJ m 39.2 25.3   16 6.32 0.645 -18.3, 64.3 0.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 69.6437 5.9595 81.3786 57.9089
129S1/SvImJ m 50.8688 5.9595 62.6036 39.1339
A/J f -9.3063 5.9595 2.4286 -21.0411
A/J m 14.0375 5.9595 25.7724 2.3026
C57BL/6J f 48.7 5.9595 60.4349 36.9651
C57BL/6J m 45.1 5.9595 56.8349 33.3651
CAST/EiJ f 43.4526 5.4688 54.2213 32.684
CAST/EiJ m 37.2889 5.6187 48.3527 26.2251
NOD/ShiLtJ f 28.8167 5.6187 39.8804 17.7529
NOD/ShiLtJ m -1.1 5.9595 10.6349 -12.8349
NZO/HlLtJ f 12.9882 5.7816 24.3728 1.6037
NZO/HlLtJ m 17.6588 5.7816 29.0433 6.2743
PWK/PhJ f 29.17 5.3304 39.666 18.674
PWK/PhJ m 16.9409 5.0823 26.9485 6.9334
WSB/EiJ f 20.5722 5.6187 31.636 9.5085
WSB/EiJ m 39.225 5.9595 50.9599 27.4901


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 60.2562 4.214 68.5541 51.9584
A/J both 2.3656 4.214 10.6634 -5.9322
C57BL/6J both 46.9 4.214 55.1978 38.6022
CAST/EiJ both 40.3708 3.9204 48.0904 32.6511
NOD/ShiLtJ both 13.8583 4.0953 21.9224 5.7943
NZO/HlLtJ both 15.3235 4.0882 23.3736 7.2735
PWK/PhJ both 23.0555 3.6825 30.3066 15.8043
WSB/EiJ both 29.8986 4.0953 37.9626 21.8346




  GWAS USING LINEAR MIXED MODELS