Project measure / variable:   GMC05   ASR_PP_81

ID, description, units MPD:55424   ASR_PP_81   acoustic startle response (ASR), 110 db sound pressure level   [amplitude]  with 81 dB prepulse stimulus  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
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  STRAIN COMPARISON PLOT
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GMC05 - acoustic startle response (ASR), 110 db sound pressure level with 81 dB prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means385   amplitude 459   amplitude
Median of the strain means203   amplitude 311   amplitude
SD of the strain means± 479 ± 463
Coefficient of variation (CV)1.24 1.01
Min–max range of strain means141   –   1554   amplitude 153   –   1582   amplitude
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 395080.3094 395080.3094 6.4491 0.0117
strain 7 52664264.0682 7523466.2955 122.8092 < 0.0001
sex:strain 7 333613.5179 47659.074 0.778 0.6063
Residuals 261 15989230.1377 61261.4182


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 177.0 64.0   16 16.0 0.362 116.0, 320.0 -0.44
129S1/SvImJ m 334.0 134.0   16 33.6 0.402 131.0, 603.0 -0.27
A/J f 211.0 179.0   16 44.9 0.852 56.8, 811.0 -0.36
A/J m 225.0 128.0   16 32.1 0.57 82.2, 479.0 -0.51
C57BL/6J f 230.0 114.0   16 28.5 0.496 112.0, 500.0 -0.32
C57BL/6J m 436.0 106.0   16 26.4 0.242 303.0, 666.0 -0.05
CAST/EiJ f 175.0 53.8   19 12.3 0.307 108.0, 263.0 -0.44
CAST/EiJ m 288.0 107.0   18 25.2 0.371 154.0, 482.0 -0.37
NOD/ShiLtJ f 141.0 36.1   18 8.5 0.255 90.4, 233.0 -0.51
NOD/ShiLtJ m 153.0 106.0   16 26.4 0.688 63.9, 508.0 -0.66
NZO/HlLtJ f 1554.0 548.0   17 133.0 0.353 733.0, 2562.0 2.44
NZO/HlLtJ m 1582.0 697.0   17 169.0 0.441 328.0, 3201.0 2.43
PWK/PhJ f 195.0 36.7   20 8.21 0.188 112.0, 261.0 -0.4
PWK/PhJ m 253.0 90.9   22 19.4 0.359 153.0, 494.0 -0.45
WSB/EiJ f 399.0 234.0   18 55.2 0.588 221.0, 1101.0 0.03
WSB/EiJ m 402.0 165.0   16 41.3 0.412 253.0, 884.0 -0.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 176.5062 61.8776 298.3491 54.6634
129S1/SvImJ m 334.0312 61.8776 455.8741 212.1884
A/J f 210.55 61.8776 332.3929 88.7071
A/J m 224.9312 61.8776 346.7741 103.0884
C57BL/6J f 229.7 61.8776 351.5429 107.8571
C57BL/6J m 435.6562 61.8776 557.4991 313.8134
CAST/EiJ f 174.9895 56.7828 286.8002 63.1788
CAST/EiJ m 288.1389 58.3388 403.0135 173.2643
NOD/ShiLtJ f 141.1889 58.3388 256.0635 26.3143
NOD/ShiLtJ m 153.4062 61.8776 275.2491 31.5634
NZO/HlLtJ f 1554.2118 60.0301 1672.4167 1436.0068
NZO/HlLtJ m 1581.5412 60.0301 1699.7461 1463.3362
PWK/PhJ f 195.03 55.345 304.0096 86.0504
PWK/PhJ m 253.1682 52.7694 357.0761 149.2602
WSB/EiJ f 398.5056 58.3388 513.3801 283.631
WSB/EiJ m 401.6687 61.8776 523.5116 279.8259


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 255.2687 43.7541 341.4247 169.1128
A/J both 217.7406 43.7541 303.8965 131.5847
C57BL/6J both 332.6781 43.7541 418.834 246.5222
CAST/EiJ both 231.5642 40.7053 311.7168 151.4115
NOD/ShiLtJ both 147.2976 42.5213 231.0261 63.5691
NZO/HlLtJ both 1567.8765 42.4477 1651.46 1484.2929
PWK/PhJ both 224.0991 38.2351 299.3876 148.8106
WSB/EiJ both 400.0872 42.5213 483.8157 316.3586




  GWAS USING LINEAR MIXED MODELS