Project measure / variable:   Nadeau2   HOMA_IR

ID, description, units MPD:53023   HOMA_IR   homeostasis model assessment insulin resistance (HOMA-IR, 16h fast)    
high-fat high-sucrose diet study
Data set, strains Nadeau2   B6.A consomic w/par   24 strains     sex: m     age: 21wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Nadeau2 - homeostasis model assessment insulin resistance (HOMA-IR, 16h fast)



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested24 strains
Mean of the strain means24.6   None
Median of the strain means21.5   None
SD of the strain means± 15.9
Coefficient of variation (CV)0.645
Min–max range of strain means3.92   –   55.4   None
Mean sample size per strain39.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 23 267022.2878 11609.6647 24.5171 < 0.0001
Residuals 954 451750.2514 473.5328


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J m 3.92 2.09   95 0.214 0.533 0.41, 12.9 -1.3
B6.A-Chr1 m 33.6 14.9   27 2.87 0.445 3.01, 69.3 0.56
B6.A-Chr10 m 8.76 7.94   76 0.91 0.906 0.68, 35.0 -1.0
B6.A-Chr11 m 24.6 17.2   36 2.87 0.699 1.78, 54.6 0.0
B6.A-Chr12 m 16.4 17.2   35 2.9 1.05 0.93, 65.4 -0.52
B6.A-Chr13 m 29.9 21.2   27 4.08 0.709 1.02, 90.6 0.33
B6.A-Chr14 m 21.8 19.3   34 3.31 0.885 2.55, 71.0 -0.18
B6.A-Chr15 m 12.7 11.4   27 2.19 0.897 0.82, 48.7 -0.75
B6.A-Chr16 m 34.3 32.0   37 5.26 0.934 3.15, 145.0 0.61
B6.A-Chr17 m 5.11 4.17   36 0.695 0.816 0.88, 17.9 -1.23
B6.A-Chr18 m 41.8 25.8   38 4.18 0.615 5.23, 104.0 1.08
B6.A-Chr19 m 47.3 39.5   34 6.77 0.834 0.96, 170.0 1.43
B6.A-Chr2 m 53.5 32.5   34 5.57 0.606 2.04, 117.0 1.82
B6.A-Chr3 m 13.7 13.1   40 2.07 0.958 0.63, 51.3 -0.69
B6.A-Chr4 m 15.4 13.9   38 2.25 0.904 1.29, 62.2 -0.58
B6.A-Chr5 m 13.0 8.98   38 1.46 0.692 1.51, 42.2 -0.73
B6.A-Chr6 m 21.7 11.6   38 1.88 0.534 1.9, 46.7 -0.18
B6.A-Chr7 m 5.47 5.03   34 0.863 0.919 0.41, 20.7 -1.21
B6.A-Chr8 m 7.78 8.63   34 1.48 1.11 0.95, 37.9 -1.06
B6.A-Chr9 m 39.5 20.9   33 3.64 0.529 5.52, 90.1 0.93
B6.A-ChrX m 55.4 34.2   36 5.69 0.617 14.4, 142.0 1.93
B6.A-ChrY m 18.0 11.4   31 2.05 0.633 1.94, 37.4 -0.42
B6.A-mt m 21.4 15.9   24 3.24 0.744 1.2, 55.3 -0.2
C57BL/6J m 46.3 40.4   96 4.13 0.873 0.57, 184.0 1.36


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J m 3.9157 2.2326 8.2971 0.0
B6.A-Chr1 m 33.5819 4.1879 41.8004 25.3634
B6.A-Chr10 m 8.7584 2.4961 13.657 3.8599
B6.A-Chr11 m 24.62 3.6268 31.7374 17.5026
B6.A-Chr12 m 16.3814 3.6782 23.5998 9.163
B6.A-Chr13 m 29.8911 4.1879 38.1096 21.6726
B6.A-Chr14 m 21.8344 3.7319 29.1582 14.5106
B6.A-Chr15 m 12.6937 4.1879 20.9122 4.4752
B6.A-Chr16 m 34.257 3.5775 41.2776 27.2364
B6.A-Chr17 m 5.1103 3.6268 12.2277 0.0
B6.A-Chr18 m 41.8445 3.5301 48.7721 34.9169
B6.A-Chr19 m 47.2803 3.7319 54.6041 39.9565
B6.A-Chr2 m 53.5344 3.7319 60.8582 46.2106
B6.A-Chr3 m 13.6795 3.4407 20.4317 6.9273
B6.A-Chr4 m 15.3671 3.5301 22.2947 8.4395
B6.A-Chr5 m 12.9734 3.5301 19.901 6.0458
B6.A-Chr6 m 21.6908 3.5301 28.6184 14.7632
B6.A-Chr7 m 5.4715 3.7319 12.7952 0.0
B6.A-Chr8 m 7.7809 3.7319 15.1047 0.4571
B6.A-Chr9 m 39.54 3.7881 46.9739 32.1061
B6.A-ChrX m 55.3697 3.6268 62.4872 48.2523
B6.A-ChrY m 18.0048 3.9084 25.6748 10.3349
B6.A-mt m 21.3592 4.4419 30.0762 12.6421
C57BL/6J m 46.3239 2.221 50.6824 41.9653




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA