Project measure / variable:   Brugnara1   Na_H_exchange

ID, description, units MPD:47406   Na_H_exchange   RBC sodium-hydrogen exchanger (NHE1; per 1013 cells)   [mmol⋅h]  
Data set, strains Brugnara1   inbred   10 strains     sex: both     age: 8wks
Procedure ion transport assessment
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  STRAIN COMPARISON PLOT
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Brugnara1 - RBC sodium-hydrogen exchanger (NHE1; per 1013 cells)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means43.3   mmol⋅h 39.4   mmol⋅h
Median of the strain means40.6   mmol⋅h 37.0   mmol⋅h
SD of the strain means± 9.37 ± 8.11
Coefficient of variation (CV)0.216 0.206
Min–max range of strain means28.0   –   60.6   mmol⋅h 29.6   –   51.3   mmol⋅h
Mean sample size per strain9.9   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1145.085 1145.085 24.7042 < 0.0001
strain 9 12032.5734 1336.9526 28.8436 < 0.0001
sex:strain 9 2478.7434 275.4159 5.9419 < 0.0001
Residuals 189 8760.502 46.3519


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 60.6 7.25   9 2.42 0.12 47.5, 69.5 1.84
129S1/SvImJ m 51.3 10.8   12 3.13 0.211 33.2, 69.3 1.46
A/J f 42.4 5.99   11 1.8 0.141 35.5, 53.7 -0.1
A/J m 35.7 5.89   10 1.86 0.165 27.4, 45.8 -0.46
BALB/cJ f 40.0 4.2   11 1.27 0.105 32.5, 47.1 -0.36
BALB/cJ m 33.0 6.4   13 1.78 0.194 22.3, 42.1 -0.79
C3H/HeJ f 49.9 12.6   10 3.97 0.252 35.8, 72.0 0.7
C3H/HeJ m 38.3 4.07   10 1.29 0.106 32.3, 44.0 -0.14
C57BL/6J f 41.3 4.67   9 1.56 0.113 32.9, 48.0 -0.22
C57BL/6J m 35.7 3.28   10 1.04 0.0919 32.6, 42.2 -0.46
C57BLKS/J f 28.0 3.04   9 1.01 0.109 22.2, 32.6 -1.64
C57BLKS/J m 30.6 9.6   15 2.48 0.314 18.1, 47.7 -1.09
CBA/J f 54.9 6.64   13 1.84 0.121 45.9, 70.0 1.23
CBA/J m 47.3 7.49   11 2.26 0.158 37.9, 59.3 0.97
DBA/2J f 39.0 5.55   10 1.76 0.143 27.0, 46.1 -0.46
DBA/2J m 51.3 8.52   11 2.57 0.166 39.0, 64.1 1.46
NZW/LacJ f 37.7 4.03   5 1.8 0.107 34.4, 44.7 -0.6
NZW/LacJ m 29.6 2.86   10 0.904 0.0967 23.4, 32.6 -1.21
SM/J f 39.6 4.27   10 1.35 0.108 34.1, 47.0 -0.4
SM/J m 41.4 3.57   10 1.13 0.0862 35.1, 46.6 0.24


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 60.5667 2.2694 65.0433 56.09
129S1/SvImJ m 51.2617 1.9654 55.1385 47.3848
A/J f 42.3818 2.0528 46.4311 38.3326
A/J m 35.74 2.1529 39.9869 31.4931
BALB/cJ f 40.0382 2.0528 44.0874 35.9889
BALB/cJ m 32.9923 1.8883 36.7171 29.2675
C3H/HeJ f 49.864 2.1529 54.1109 45.6171
C3H/HeJ m 38.331 2.1529 42.5779 34.0841
C57BL/6J f 41.2967 2.2694 45.7733 36.82
C57BL/6J m 35.665 2.1529 39.9119 31.4181
C57BLKS/J f 27.9789 2.2694 32.4555 23.5023
C57BLKS/J m 30.5913 1.7579 34.0589 27.1238
CBA/J f 54.8962 1.8883 58.6209 51.1714
CBA/J m 47.3191 2.0528 51.3683 43.2698
DBA/2J f 38.962 2.1529 43.2089 34.7151
DBA/2J m 51.3136 2.0528 55.3629 47.2644
NZW/LacJ f 37.692 3.0447 43.698 31.686
NZW/LacJ m 29.552 2.1529 33.7989 25.3051
SM/J f 39.572 2.1529 43.8189 35.3251
SM/J m 41.383 2.1529 45.6299 37.1361


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 55.9142 1.5011 58.8752 52.9532
A/J both 39.0609 1.4874 41.9949 36.1269
BALB/cJ both 36.5152 1.3946 39.2662 33.7643
C3H/HeJ both 44.0975 1.5224 47.1005 41.0945
C57BL/6J both 38.4808 1.5641 41.5661 35.3955
C57BLKS/J both 29.2851 1.4353 32.1164 26.4538
CBA/J both 51.1076 1.3946 53.8585 48.3567
DBA/2J both 45.1378 1.4874 48.0718 42.2039
NZW/LacJ both 33.622 1.8645 37.2999 29.9441
SM/J both 40.4775 1.5224 43.4805 37.4745




  GWAS USING LINEAR MIXED MODELS