Project measure / variable:   Brugnara1   K_Cl

ID, description, units MPD:47404   K_Cl   RBC potassium chloride cotransport (KCC; per 1013 cells)   [mmol⋅h]  
Data set, strains Brugnara1   inbred   10 strains     sex: both     age: 8wks
Procedure ion transport assessment
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  STRAIN COMPARISON PLOT
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Brugnara1 - RBC potassium chloride cotransport (KCC; per 1013 cells)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means9.49   mmol⋅h 9.33   mmol⋅h
Median of the strain means9.04   mmol⋅h 8.73   mmol⋅h
SD of the strain means± 3.19 ± 4.34
Coefficient of variation (CV)0.336 0.465
Min–max range of strain means5.30   –   14.4   mmol⋅h 4.69   –   17.7   mmol⋅h
Mean sample size per strain12.9   mice 14.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 12.3635 12.3635 1.9205 0.167
strain 9 2783.8824 309.3203 48.048 < 0.0001
sex:strain 9 424.6585 47.1843 7.3293 < 0.0001
Residuals 259 1667.3742 6.4377


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 5.6 1.69   18 0.399 0.302 2.52, 9.11 -1.22
129S1/SvImJ m 5.36 1.21   21 0.263 0.225 3.36, 8.13 -0.91
A/J f 7.71 1.41   16 0.353 0.183 4.99, 10.7 -0.56
A/J m 7.36 1.13   16 0.282 0.153 5.7, 9.2 -0.45
BALB/cJ f 9.24 2.31   13 0.64 0.25 6.04, 13.0 -0.08
BALB/cJ m 11.4 2.51   12 0.724 0.221 7.92, 16.8 0.48
C3H/HeJ f 9.32 2.53   7 0.956 0.271 5.54, 12.6 -0.05
C3H/HeJ m 10.1 1.9   20 0.424 0.188 6.51, 13.7 0.18
C57BL/6J f 8.02 2.03   21 0.443 0.253 4.2, 11.0 -0.46
C57BL/6J m 10.6 2.13   18 0.502 0.2 7.06, 16.0 0.29
C57BLKS/J f 8.83 1.27   13 0.351 0.143 6.43, 10.3 -0.21
C57BLKS/J m 4.69 1.22   14 0.327 0.261 2.82, 6.63 -1.07
CBA/J f 12.8 1.97   5 0.882 0.154 10.2, 14.9 1.04
CBA/J m 6.81 2.52   12 0.727 0.37 3.95, 10.8 -0.58
DBA/2J f 5.3 1.43   16 0.357 0.27 3.1, 7.63 -1.32
DBA/2J m 4.87 1.44   11 0.435 0.296 3.31, 8.72 -1.03
NZW/LacJ f 13.7 4.08   11 1.23 0.299 8.35, 19.5 1.32
NZW/LacJ m 17.7 7.24   10 2.29 0.41 10.1, 29.5 1.93
SM/J f 14.4 3.71   9 1.24 0.259 9.5, 20.2 1.54
SM/J m 14.4 3.8   16 0.951 0.265 8.64, 19.3 1.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 5.6 0.598 6.7776 4.4224
129S1/SvImJ m 5.3571 0.5537 6.4474 4.2669
A/J f 7.7138 0.6343 8.9628 6.4647
A/J m 7.3612 0.6343 8.6103 6.1122
BALB/cJ f 9.2415 0.7037 10.6273 7.8558
BALB/cJ m 11.3525 0.7324 12.7948 9.9102
C3H/HeJ f 9.3214 0.959 11.2099 7.433
C3H/HeJ m 10.0795 0.5674 11.1967 8.9623
C57BL/6J f 8.0229 0.5537 9.1131 6.9326
C57BL/6J m 10.6311 0.598 11.8088 9.4535
C57BLKS/J f 8.8262 0.7037 10.2119 7.4404
C57BLKS/J m 4.6871 0.6781 6.0225 3.3518
CBA/J f 12.788 1.1347 15.0224 10.5536
CBA/J m 6.8075 0.7324 8.2498 5.3652
DBA/2J f 5.3 0.6343 6.5491 4.0509
DBA/2J m 4.8736 0.765 6.3801 3.3672
NZW/LacJ f 13.6691 0.765 15.1755 12.1626
NZW/LacJ m 17.676 0.8024 19.256 16.096
SM/J f 14.3544 0.8458 16.0199 12.689
SM/J m 14.3637 0.6343 15.6128 13.1147


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 5.4786 0.4075 6.281 4.6761
A/J both 7.5375 0.4485 8.4207 6.6543
BALB/cJ both 10.297 0.5079 11.2971 9.297
C3H/HeJ both 9.7005 0.5571 10.7975 8.6034
C57BL/6J both 9.327 0.4075 10.1294 8.5246
C57BLKS/J both 6.7566 0.4886 7.7188 5.7944
CBA/J both 9.7978 0.6753 11.1275 8.468
DBA/2J both 5.0868 0.4969 6.0653 4.1084
NZW/LacJ both 15.6725 0.5543 16.7641 14.581
SM/J both 14.3591 0.5286 15.4 13.3182




  GWAS USING LINEAR MIXED MODELS