Project measure / variable:   Thomsen1   activ_cocaine2_3

ID, description, units MPD:40708   activ_cocaine2_3   total activity, test 2, 3h test   [n]  dose 3 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 2, 3h test dose 3 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2966   n 2269   n
Median of the strain means2600   n 2083   n
SD of the strain means± 2743 ± 2055
Coefficient of variation (CV)0.925 0.906
Min–max range of strain means243   –   9819   n 275   –   7142   n
Mean sample size per strain7.9   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 29316932.9412 29316932.9412 8.4358 0.0041
strain 14 1172686649.9114 83763332.1365 24.1026 < 0.0001
sex:strain 14 123118989.4541 8794213.5324 2.5305 0.0024
Residuals 202 702008049.4821 3475287.3737


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 509.0 140.0   8 49.6 0.276 264.0, 699.0 -0.9
129S1/SvImJ m 445.0 148.0   8 52.1 0.332 236.0, 604.0 -0.89
129S6/SvEvTac f 410.0 177.0   8 62.7 0.433 31.0, 609.0 -0.93
129S6/SvEvTac m 352.0 167.0   8 59.0 0.474 126.0, 574.0 -0.93
129X1/SvJ f 243.0 143.0   8 50.7 0.59 110.0, 547.0 -0.99
129X1/SvJ m 275.0 183.0   8 64.7 0.666 103.0, 611.0 -0.97
A/J f 1342.0 384.0   8 136.0 0.286 665.0, 1994.0 -0.59
A/J m 1607.0 839.0   8 297.0 0.522 832.0, 3420.0 -0.32
BALB/cByJ f 4965.0 1429.0   8 505.0 0.288 2033.0, 6202.0 0.73
BALB/cByJ m 6227.0 1507.0   8 533.0 0.242 4029.0, 8925.0 1.93
BALB/cJ f 4755.0 2443.0   7 923.0 0.514 768.0, 8321.0 0.65
BALB/cJ m 2556.0 2493.0   8 881.0 0.975 679.0, 7426.0 0.14
C3H/HeJ f 799.0 280.0   8 98.9 0.35 381.0, 1255.0 -0.79
C3H/HeJ m 2363.0 1161.0   8 411.0 0.491 1188.0, 4934.0 0.05
C57BL/6J f 6508.0 6531.0   8 2309.0 1.0 1476.0, 22007.0 1.29
C57BL/6J m 2324.0 870.0   8 307.0 0.374 1559.0, 4359.0 0.03
CAST/EiJ f 4490.0 1789.0   8 632.0 0.398 1864.0, 6697.0 0.56
CAST/EiJ m 3416.0 1271.0   4 636.0 0.372 1732.0, 4522.0 0.56
Crl:CD-1(ICR) f 3152.0 3304.0   8 1168.0 1.05 365.0, 7978.0 0.07
Crl:CD-1(ICR) m 2801.0 3343.0   8 1182.0 1.19 420.0, 8254.0 0.26
DBA/2J f 2600.0 1906.0   8 674.0 0.733 507.0, 6530.0 -0.13
DBA/2J m 1115.0 439.0   8 155.0 0.394 414.0, 1687.0 -0.56
FVB/NJ f 9819.0 1236.0   8 437.0 0.126 7802.0, 11885.0 2.5
FVB/NJ m 7142.0 1157.0   8 409.0 0.162 5275.0, 8396.0 2.37
SJL/J f 1075.0 489.0   8 173.0 0.455 483.0, 1948.0 -0.69
SJL/J m 800.0 284.0   8 100.0 0.355 423.0, 1186.0 -0.71
SPRET/EiJ f 678.0 217.0   7 82.2 0.321 474.0, 1065.0 -0.83
SPRET/EiJ m 522.0 280.0   6 114.0 0.537 134.0, 821.0 -0.85
Tac:SW f 3141.0 1068.0   8 378.0 0.34 2203.0, 5407.0 0.06
Tac:SW m 2083.0 2136.0   8 755.0 1.03 421.0, 7040.0 -0.09


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 508.625 659.0986 1808.2206 0.0
129S1/SvImJ m 444.75 659.0986 1744.3456 0.0
129S6/SvEvTac f 410.0 659.0986 1709.5956 0.0
129S6/SvEvTac m 352.5 659.0986 1652.0956 0.0
129X1/SvJ f 242.75 659.0986 1542.3456 0.0
129X1/SvJ m 274.75 659.0986 1574.3456 0.0
A/J f 1341.625 659.0986 2641.2206 42.0294
A/J m 1607.375 659.0986 2906.9706 307.7794
BALB/cByJ f 4964.75 659.0986 6264.3456 3665.1544
BALB/cByJ m 6226.75 659.0986 7526.3456 4927.1544
BALB/cJ f 4755.0 704.606 6144.3262 3365.6738
BALB/cJ m 2555.625 659.0986 3855.2206 1256.0294
C3H/HeJ f 799.125 659.0986 2098.7206 0.0
C3H/HeJ m 2363.0 659.0986 3662.5956 1063.4044
C57BL/6J f 6508.0 659.0986 7807.5956 5208.4044
C57BL/6J m 2324.375 659.0986 3623.9706 1024.7794
CAST/EiJ f 4490.0 659.0986 5789.5956 3190.4044
CAST/EiJ m 3415.5 932.1061 5253.4058 1577.5942
Crl:CD-1(ICR) f 3152.5 659.0986 4452.0956 1852.9044
Crl:CD-1(ICR) m 2801.0 659.0986 4100.5956 1501.4044
DBA/2J f 2599.5 659.0986 3899.0956 1299.9044
DBA/2J m 1114.625 659.0986 2414.2206 0.0
FVB/NJ f 9818.75 659.0986 11118.3456 8519.1544
FVB/NJ m 7141.875 659.0986 8441.4706 5842.2794
SJL/J f 1074.625 659.0986 2374.2206 0.0
SJL/J m 799.5 659.0986 2099.0956 0.0
SPRET/EiJ f 678.1429 704.606 2067.469 0.0
SPRET/EiJ m 522.0 761.0615 2022.6438 0.0
Tac:SW f 3141.375 659.0986 4440.9706 1841.7794
Tac:SW m 2082.625 659.0986 3382.2206 783.0294


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 476.6875 466.0531 1395.6404 0.0
129S6/SvEvTac both 381.25 466.0531 1300.2029 0.0
129X1/SvJ both 258.75 466.0531 1177.7029 0.0
A/J both 1474.5 466.0531 2393.4529 555.5471
BALB/cByJ both 5595.75 466.0531 6514.7029 4676.7971
BALB/cJ both 3655.3125 482.4108 4606.5191 2704.1059
C3H/HeJ both 1581.0625 466.0531 2500.0154 662.1096
C57BL/6J both 4416.1875 466.0531 5335.1404 3497.2346
CAST/EiJ both 3952.75 570.7961 5078.2328 2827.2672
Crl:CD-1(ICR) both 2976.75 466.0531 3895.7029 2057.7971
DBA/2J both 1857.0625 466.0531 2776.0154 938.1096
FVB/NJ both 8480.3125 466.0531 9399.2654 7561.3596
SJL/J both 937.0625 466.0531 1856.0154 18.1096
SPRET/EiJ both 600.0714 518.576 1622.5878 0.0
Tac:SW both 2612.0 466.0531 3530.9529 1693.0471




  GWAS USING LINEAR MIXED MODELS