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Project measure / variable:   Thomsen1   activ_cocaine2_0

ID, description, units MPD:40707   activ_cocaine2_0   total activity, test 2, 3h test   [n]  baseline  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 2, 3h test baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2561   n 2071   n
Median of the strain means1607   n 1576   n
SD of the strain means± 2368 ± 1905
Coefficient of variation (CV)0.925 0.920
Min–max range of strain means318   –   8309   n 277   –   6314   n
Mean sample size per strain7.9   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 16941716.3297 16941716.3297 7.57 0.0065
strain 14 913043481.584 65217391.5417 29.1408 < 0.0001
sex:strain 14 84091634.2216 6006545.3015 2.6839 0.0013
Residuals 202 452078313.244 2238011.4517


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 460.0 192.0   8 67.8 0.416 130.0, 746.0 -0.89
129S1/SvImJ m 545.0 319.0   8 113.0 0.586 113.0, 1133.0 -0.8
129S6/SvEvTac f 466.0 235.0   8 83.1 0.504 99.0, 759.0 -0.88
129S6/SvEvTac m 439.0 185.0   8 65.4 0.422 206.0, 716.0 -0.86
129X1/SvJ f 318.0 176.0   8 62.2 0.553 149.0, 606.0 -0.95
129X1/SvJ m 277.0 113.0   8 40.1 0.409 169.0, 485.0 -0.94
A/J f 1607.0 995.0   8 352.0 0.619 777.0, 3890.0 -0.4
A/J m 1576.0 914.0   8 323.0 0.58 796.0, 3479.0 -0.26
BALB/cByJ f 5072.0 1251.0   8 442.0 0.247 3139.0, 6440.0 1.06
BALB/cByJ m 5566.0 1085.0   8 384.0 0.195 4053.0, 7318.0 1.83
BALB/cJ f 4850.0 2966.0   7 1121.0 0.612 1247.0, 8464.0 0.97
BALB/cJ m 2172.0 1441.0   8 509.0 0.663 1055.0, 5398.0 0.05
C3H/HeJ f 749.0 304.0   8 107.0 0.406 329.0, 1329.0 -0.77
C3H/HeJ m 1426.0 755.0   8 267.0 0.529 637.0, 2702.0 -0.34
C57BL/6J f 5224.0 4189.0   8 1481.0 0.802 1792.0, 14907.0 1.12
C57BL/6J m 1991.0 1094.0   8 387.0 0.55 353.0, 3922.0 -0.04
CAST/EiJ f 2943.0 1054.0   8 373.0 0.358 1500.0, 4460.0 0.16
CAST/EiJ m 4399.0 3268.0   4 1634.0 0.743 1411.0, 8820.0 1.22
Crl:CD-1(ICR) f 2904.0 2763.0   8 977.0 0.952 369.0, 7291.0 0.14
Crl:CD-1(ICR) m 2609.0 2956.0   8 1045.0 1.13 299.0, 7081.0 0.28
DBA/2J f 950.0 522.0   8 185.0 0.55 294.0, 1812.0 -0.68
DBA/2J m 1055.0 659.0   8 233.0 0.625 226.0, 1983.0 -0.53
FVB/NJ f 8309.0 1353.0   8 478.0 0.163 5963.0, 10756.0 2.43
FVB/NJ m 6314.0 1316.0   8 465.0 0.208 4090.0, 7946.0 2.23
SJL/J f 1333.0 1658.0   8 586.0 1.24 304.0, 5347.0 -0.52
SJL/J m 668.0 123.0   8 43.5 0.184 499.0, 814.0 -0.74
SPRET/EiJ f 468.0 197.0   7 74.6 0.422 245.0, 757.0 -0.88
SPRET/EiJ m 400.0 228.0   6 93.3 0.572 160.0, 829.0 -0.88
Tac:SW f 2759.0 803.0   8 284.0 0.291 1267.0, 3699.0 0.08
Tac:SW m 1627.0 952.0   8 336.0 0.585 684.0, 3584.0 -0.23


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 460.5 528.9153 1503.4033 0.0
129S1/SvImJ m 544.625 528.9153 1587.5283 0.0
129S6/SvEvTac f 466.0 528.9153 1508.9033 0.0
129S6/SvEvTac m 439.0 528.9153 1481.9033 0.0
129X1/SvJ f 318.25 528.9153 1361.1533 0.0
129X1/SvJ m 276.75 528.9153 1319.6533 0.0
A/J f 1607.125 528.9153 2650.0283 564.2217
A/J m 1576.375 528.9153 2619.2783 533.4717
BALB/cByJ f 5071.5 528.9153 6114.4033 4028.5967
BALB/cByJ m 5566.25 528.9153 6609.1533 4523.3467
BALB/cJ f 4849.8571 565.4343 5964.7677 3734.9466
BALB/cJ m 2171.625 528.9153 3214.5283 1128.7217
C3H/HeJ f 749.375 528.9153 1792.2783 0.0
C3H/HeJ m 1426.125 528.9153 2469.0283 383.2217
C57BL/6J f 5223.625 528.9153 6266.5283 4180.7217
C57BL/6J m 1990.75 528.9153 3033.6533 947.8467
CAST/EiJ f 2942.75 528.9153 3985.6533 1899.8467
CAST/EiJ m 4399.0 747.9992 5873.888 2924.112
Crl:CD-1(ICR) f 2904.0 528.9153 3946.9033 1861.0967
Crl:CD-1(ICR) m 2609.125 528.9153 3652.0283 1566.2217
DBA/2J f 949.625 528.9153 1992.5283 0.0
DBA/2J m 1054.625 528.9153 2097.5283 11.7217
FVB/NJ f 8308.625 528.9153 9351.5283 7265.7217
FVB/NJ m 6314.375 528.9153 7357.2783 5271.4717
SJL/J f 1332.875 528.9153 2375.7783 289.9717
SJL/J m 668.125 528.9153 1711.0283 0.0
SPRET/EiJ f 467.7143 565.4343 1582.6248 0.0
SPRET/EiJ m 399.6667 610.7388 1603.9077 0.0
Tac:SW f 2759.0 528.9153 3801.9033 1716.0967
Tac:SW m 1626.875 528.9153 2669.7783 583.9717


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 502.5625 373.9996 1240.0065 0.0
129S6/SvEvTac both 452.5 373.9996 1189.944 0.0
129X1/SvJ both 297.5 373.9996 1034.944 0.0
A/J both 1591.75 373.9996 2329.194 854.306
BALB/cByJ both 5318.875 373.9996 6056.319 4581.431
BALB/cJ both 3510.7411 387.1264 4274.0681 2747.414
C3H/HeJ both 1087.75 373.9996 1825.194 350.306
C57BL/6J both 3607.1875 373.9996 4344.6315 2869.7435
CAST/EiJ both 3670.875 458.0541 4574.0557 2767.6943
Crl:CD-1(ICR) both 2756.5625 373.9996 3494.0065 2019.1185
DBA/2J both 1002.125 373.9996 1739.569 264.681
FVB/NJ both 7311.5 373.9996 8048.944 6574.056
SJL/J both 1000.5 373.9996 1737.944 263.056
SPRET/EiJ both 433.6905 416.1484 1254.2424 0.0
Tac:SW both 2192.9375 373.9996 2930.3815 1455.4935




  GWAS USING LINEAR MIXED MODELS