Project measure / variable:   Thomsen1   activ_cocaine1_32

ID, description, units MPD:40705   activ_cocaine1_32   total activity, test 1, 3h test   [n]  dose 32 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test dose 32 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means4154   n 4337   n
Median of the strain means2935   n 3611   n
SD of the strain means± 3144 ± 3138
Coefficient of variation (CV)0.757 0.724
Min–max range of strain means352   –   9314   n 532   –   9976   n
Mean sample size per strain7.9   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 34701.58 34701.58 0.0057 0.9399
strain 14 1960953372.4227 140068098.0302 22.9914 < 0.0001
sex:strain 14 107360647.5157 7668617.6797 1.2588 0.2359
Residuals 202 1230621038.9643 6092183.3612


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 729.0 194.0   8 68.6 0.266 345.0, 956.0 -1.09
129S1/SvImJ m 1165.0 472.0   8 167.0 0.405 437.0, 1923.0 -1.01
129S6/SvEvTac f 352.0 157.0   8 55.3 0.445 200.0, 650.0 -1.21
129S6/SvEvTac m 532.0 162.0   8 57.1 0.304 242.0, 775.0 -1.21
129X1/SvJ f 937.0 343.0   8 121.0 0.366 415.0, 1542.0 -1.02
129X1/SvJ m 1154.0 957.0   8 338.0 0.829 337.0, 3234.0 -1.01
A/J f 1124.0 733.0   8 259.0 0.652 560.0, 2787.0 -0.96
A/J m 1088.0 447.0   8 158.0 0.411 575.0, 1665.0 -1.04
BALB/cByJ f 5916.0 2411.0   8 852.0 0.407 742.0, 8826.0 0.56
BALB/cByJ m 8491.0 1667.0   8 590.0 0.196 6262.0, 10746.0 1.32
BALB/cJ f 6839.0 2303.0   8 814.0 0.337 3446.0, 10246.0 0.85
BALB/cJ m 3707.0 3409.0   8 1205.0 0.92 1250.0, 10924.0 -0.2
C3H/HeJ f 2935.0 832.0   7 315.0 0.284 1733.0, 4280.0 -0.39
C3H/HeJ m 3963.0 1681.0   7 635.0 0.424 1847.0, 6301.0 -0.12
C57BL/6J f 9296.0 4438.0   8 1569.0 0.477 5007.0, 18760.0 1.64
C57BL/6J m 7762.0 3416.0   8 1208.0 0.44 3383.0, 12987.0 1.09
CAST/EiJ f 8232.0 2829.0   8 1000.0 0.344 4806.0, 13374.0 1.3
CAST/EiJ m 9976.0 2928.0   4 1464.0 0.294 6144.0, 12340.0 1.8
Crl:CD-1(ICR) f 4511.0 3177.0   8 1123.0 0.704 1044.0, 10237.0 0.11
Crl:CD-1(ICR) m 5710.0 6244.0   8 2208.0 1.09 566.0, 16250.0 0.44
DBA/2J f 2738.0 1912.0   8 676.0 0.698 1196.0, 6567.0 -0.45
DBA/2J m 3611.0 1972.0   8 697.0 0.546 1205.0, 5934.0 -0.23
FVB/NJ f 9314.0 3535.0   8 1250.0 0.379 4938.0, 16558.0 1.64
FVB/NJ m 9070.0 3932.0   8 1390.0 0.434 3441.0, 13073.0 1.51
SJL/J f 2392.0 2044.0   8 723.0 0.854 120.0, 5080.0 -0.56
SJL/J m 2866.0 2221.0   8 785.0 0.775 338.0, 6218.0 -0.47
SPRET/EiJ f 1911.0 1065.0   7 403.0 0.557 590.0, 3339.0 -0.71
SPRET/EiJ m 2416.0 1827.0   7 691.0 0.756 943.0, 5699.0 -0.61
Tac:SW f 5083.0 1236.0   8 437.0 0.243 3224.0, 6580.0 0.3
Tac:SW m 3539.0 1757.0   8 621.0 0.496 619.0, 6449.0 -0.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 728.625 872.6528 2449.3021 0.0
129S1/SvImJ m 1164.75 872.6528 2885.4271 0.0
129S6/SvEvTac f 351.75 872.6528 2072.4271 0.0
129S6/SvEvTac m 531.875 872.6528 2252.5521 0.0
129X1/SvJ f 937.375 872.6528 2658.0521 0.0
129X1/SvJ m 1153.875 872.6528 2874.5521 0.0
A/J f 1123.875 872.6528 2844.5521 0.0
A/J m 1087.5 872.6528 2808.1771 0.0
BALB/cByJ f 5915.5 872.6528 7636.1771 4194.8229
BALB/cByJ m 8490.75 872.6528 10211.4271 6770.0729
BALB/cJ f 6838.875 872.6528 8559.5521 5118.1979
BALB/cJ m 3707.375 872.6528 5428.0521 1986.6979
C3H/HeJ f 2935.2857 932.9051 4774.7669 1095.8046
C3H/HeJ m 3963.4286 932.9051 5802.9097 2123.9474
C57BL/6J f 9296.125 872.6528 11016.8021 7575.4479
C57BL/6J m 7761.75 872.6528 9482.4271 6041.0729
CAST/EiJ f 8231.625 872.6528 9952.3021 6510.9479
CAST/EiJ m 9976.0 1234.1174 12409.4048 7542.5952
Crl:CD-1(ICR) f 4511.0 872.6528 6231.6771 2790.3229
Crl:CD-1(ICR) m 5710.25 872.6528 7430.9271 3989.5729
DBA/2J f 2737.875 872.6528 4458.5521 1017.1979
DBA/2J m 3610.625 872.6528 5331.3021 1889.9479
FVB/NJ f 9314.5 872.6528 11035.1771 7593.8229
FVB/NJ m 9069.75 872.6528 10790.4271 7349.0729
SJL/J f 2392.5 872.6528 4113.1771 671.8229
SJL/J m 2865.875 872.6528 4586.5521 1145.1979
SPRET/EiJ f 1911.4286 932.9051 3750.9097 71.9474
SPRET/EiJ m 2416.1429 932.9051 4255.624 576.6617
Tac:SW f 5082.875 872.6528 6803.5521 3362.1979
Tac:SW m 3538.625 872.6528 5259.3021 1817.9479


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 946.6875 617.0587 2163.3899 0.0
129S6/SvEvTac both 441.8125 617.0587 1658.5149 0.0
129X1/SvJ both 1045.625 617.0587 2262.3274 0.0
A/J both 1105.6875 617.0587 2322.3899 0.0
BALB/cByJ both 7203.125 617.0587 8419.8274 5986.4226
BALB/cJ both 5273.125 617.0587 6489.8274 4056.4226
C3H/HeJ both 3449.3571 659.6635 4750.0667 2148.6475
C57BL/6J both 8528.9375 617.0587 9745.6399 7312.2351
CAST/EiJ both 9103.8125 755.7395 10593.9626 7613.6624
Crl:CD-1(ICR) both 5110.625 617.0587 6327.3274 3893.9226
DBA/2J both 3174.25 617.0587 4390.9524 1957.5476
FVB/NJ both 9192.125 617.0587 10408.8274 7975.4226
SJL/J both 2629.1875 617.0587 3845.8899 1412.4851
SPRET/EiJ both 2163.7857 659.6635 3464.4953 863.0761
Tac:SW both 4310.75 617.0587 5527.4524 3094.0476




  GWAS USING LINEAR MIXED MODELS