Project measure / variable:   Thomsen1   activ_cocaine1_18


  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test dose 18 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means3490   n 3606   n
Median of the strain means2737   n 3612   n
SD of the strain means± 2850 ± 3015
Coefficient of variation (CV)0.816 0.836
Min–max range of strain means287   –   8635   n 508   –   9213   n
Mean sample size per strain7.9   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 431974.8156 431974.8156 0.1064 0.7446
strain 14 1658251378.904 118446527.0646 29.1881 < 0.0001
sex:strain 14 129340149.5002 9238582.1072 2.2766 0.0066
Residuals 203 823782246.6429 4058040.6239


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 687.0 128.0   8 45.2 0.186 508.0, 883.0 -0.98
129S1/SvImJ m 873.0 451.0   8 160.0 0.517 398.0, 1563.0 -0.91
129S6/SvEvTac f 287.0 158.0   8 55.9 0.551 74.0, 527.0 -1.12
129S6/SvEvTac m 633.0 263.0   8 92.8 0.415 227.0, 971.0 -0.99
129X1/SvJ f 398.0 209.0   8 73.8 0.525 88.0, 676.0 -1.09
129X1/SvJ m 508.0 318.0   8 113.0 0.627 118.0, 1021.0 -1.03
A/J f 1294.0 832.0   8 294.0 0.643 541.0, 2889.0 -0.77
A/J m 912.0 429.0   8 152.0 0.471 463.0, 1550.0 -0.89
BALB/cByJ f 5315.0 2031.0   8 718.0 0.382 1412.0, 8181.0 0.64
BALB/cByJ m 7591.0 1168.0   8 413.0 0.154 6126.0, 9632.0 1.32
BALB/cJ f 6522.0 1652.0   8 584.0 0.253 4987.0, 9223.0 1.06
BALB/cJ m 3744.0 2875.0   8 1016.0 0.768 980.0, 8395.0 0.05
C3H/HeJ f 2737.0 1947.0   7 736.0 0.711 731.0, 6911.0 -0.26
C3H/HeJ m 3997.0 1935.0   8 684.0 0.484 1691.0, 6734.0 0.13
C57BL/6J f 8301.0 2074.0   8 733.0 0.25 5949.0, 12085.0 1.69
C57BL/6J m 5765.0 4123.0   8 1458.0 0.715 955.0, 12133.0 0.72
CAST/EiJ f 5460.0 2461.0   8 870.0 0.451 72.0, 7879.0 0.69
CAST/EiJ m 9213.0 5064.0   4 2532.0 0.55 2881.0, 14968.0 1.86
Crl:CD-1(ICR) f 3539.0 2674.0   8 946.0 0.756 777.0, 7934.0 0.02
Crl:CD-1(ICR) m 3793.0 4314.0   8 1525.0 1.14 1049.0, 13159.0 0.06
DBA/2J f 1766.0 1215.0   8 429.0 0.688 402.0, 4281.0 -0.61
DBA/2J m 1535.0 772.0   8 273.0 0.503 1037.0, 3351.0 -0.69
FVB/NJ f 8635.0 2250.0   8 796.0 0.261 4460.0, 11690.0 1.81
FVB/NJ m 8951.0 3088.0   8 1092.0 0.345 3772.0, 12049.0 1.77
SJL/J f 1345.0 1502.0   8 531.0 1.12 296.0, 4214.0 -0.75
SJL/J m 1520.0 775.0   8 274.0 0.51 532.0, 2520.0 -0.69
SPRET/EiJ f 1216.0 708.0   7 268.0 0.582 385.0, 1998.0 -0.8
SPRET/EiJ m 1443.0 888.0   7 336.0 0.615 377.0, 2553.0 -0.72
Tac:SW f 4851.0 2408.0   8 851.0 0.496 2288.0, 8768.0 0.48
Tac:SW m 3612.0 1527.0   8 540.0 0.423 1343.0, 5632.0 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 687.375 712.2184 2091.6695 0.0
129S1/SvImJ m 872.875 712.2184 2277.1695 0.0
129S6/SvEvTac f 287.125 712.2184 1691.4195 0.0
129S6/SvEvTac m 632.875 712.2184 2037.1695 0.0
129X1/SvJ f 398.0 712.2184 1802.2945 0.0
129X1/SvJ m 507.875 712.2184 1912.1695 0.0
A/J f 1294.375 712.2184 2698.6695 0.0
A/J m 911.625 712.2184 2315.9195 0.0
BALB/cByJ f 5314.75 712.2184 6719.0445 3910.4555
BALB/cByJ m 7591.25 712.2184 8995.5445 6186.9555
BALB/cJ f 6522.5 712.2184 7926.7945 5118.2055
BALB/cJ m 3744.375 712.2184 5148.6695 2340.0805
C3H/HeJ f 2737.4286 761.3935 4238.6825 1236.1746
C3H/HeJ m 3996.75 712.2184 5401.0445 2592.4555
C57BL/6J f 8301.25 712.2184 9705.5445 6896.9555
C57BL/6J m 5764.875 712.2184 7169.1695 4360.5805
CAST/EiJ f 5460.125 712.2184 6864.4195 4055.8305
CAST/EiJ m 9213.25 1007.2289 11199.2223 7227.2777
Crl:CD-1(ICR) f 3539.375 712.2184 4943.6695 2135.0805
Crl:CD-1(ICR) m 3792.75 712.2184 5197.0445 2388.4555
DBA/2J f 1766.125 712.2184 3170.4195 361.8305
DBA/2J m 1535.25 712.2184 2939.5445 130.9555
FVB/NJ f 8634.625 712.2184 10038.9195 7230.3305
FVB/NJ m 8951.125 712.2184 10355.4195 7546.8305
SJL/J f 1345.0 712.2184 2749.2945 0.0
SJL/J m 1520.25 712.2184 2924.5445 115.9555
SPRET/EiJ f 1215.5714 761.3935 2716.8254 0.0
SPRET/EiJ m 1443.4286 761.3935 2944.6825 0.0
Tac:SW f 4851.0 712.2184 6255.2945 3446.7055
Tac:SW m 3612.5 712.2184 5016.7945 2208.2055


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 780.125 503.6145 1773.1112 0.0
129S6/SvEvTac both 460.0 503.6145 1452.9862 0.0
129X1/SvJ both 452.9375 503.6145 1445.9237 0.0
A/J both 1103.0 503.6145 2095.9862 110.0138
BALB/cByJ both 6453.0 503.6145 7445.9862 5460.0138
BALB/cJ both 5133.4375 503.6145 6126.4237 4140.4513
C3H/HeJ both 3367.0893 521.2905 4394.9276 2339.251
C57BL/6J both 7033.0625 503.6145 8026.0487 6040.0763
CAST/EiJ both 7336.6875 616.7992 8552.8422 6120.5328
Crl:CD-1(ICR) both 3666.0625 503.6145 4659.0487 2673.0763
DBA/2J both 1650.6875 503.6145 2643.6737 657.7013
FVB/NJ both 8792.875 503.6145 9785.8612 7799.8888
SJL/J both 1432.625 503.6145 2425.6112 439.6388
SPRET/EiJ both 1329.5 538.3865 2391.0468 267.9532
Tac:SW both 4231.75 503.6145 5224.7362 3238.7638




  GWAS USING LINEAR MIXED MODELS