Project measure / variable:   Thomsen1   activ_cocaine1_0

ID, description, units MPD:40701   activ_cocaine1_0   total activity, test 1, 3h test   [n]  baseline  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2712   n 2020   n
Median of the strain means1116   n 1441   n
SD of the strain means± 2572 ± 1871
Coefficient of variation (CV)0.948 0.926
Min–max range of strain means284   –   7181   n 299   –   6710   n
Mean sample size per strain7.9   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 32565755.8995 32565755.8995 6.2566 0.0132
strain 14 985987443.5636 70427674.5403 13.5306 < 0.0001
sex:strain 14 132493871.0339 9463847.931 1.8182 0.0379
Residuals 202 1051420966.4643 5205054.2894


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 418.0 122.0   8 43.1 0.292 279.0, 622.0 -0.89
129S1/SvImJ m 764.0 252.0   8 89.0 0.329 287.0, 1173.0 -0.67
129S6/SvEvTac f 308.0 138.0   8 48.7 0.447 126.0, 505.0 -0.93
129S6/SvEvTac m 418.0 152.0   8 53.9 0.364 240.0, 664.0 -0.86
129X1/SvJ f 284.0 198.0   8 70.0 0.696 85.0, 657.0 -0.94
129X1/SvJ m 299.0 213.0   8 75.2 0.712 67.0, 787.0 -0.92
A/J f 806.0 410.0   8 145.0 0.508 411.0, 1625.0 -0.74
A/J m 963.0 574.0   8 203.0 0.596 276.0, 1598.0 -0.56
BALB/cByJ f 4257.0 1968.0   8 696.0 0.462 1197.0, 6684.0 0.6
BALB/cByJ m 5174.0 975.0   8 345.0 0.188 3232.0, 6471.0 1.69
BALB/cJ f 6423.0 1845.0   8 652.0 0.287 3073.0, 9014.0 1.44
BALB/cJ m 2868.0 3482.0   8 1231.0 1.21 300.0, 9922.0 0.45
C3H/HeJ f 870.0 292.0   7 110.0 0.335 503.0, 1340.0 -0.72
C3H/HeJ m 1730.0 738.0   7 279.0 0.427 978.0, 3051.0 -0.15
C57BL/6J f 6571.0 4448.0   8 1573.0 0.677 3572.0, 16621.0 1.5
C57BL/6J m 2153.0 1310.0   8 463.0 0.609 896.0, 4509.0 0.07
CAST/EiJ f 3797.0 2112.0   8 747.0 0.556 1367.0, 7089.0 0.42
CAST/EiJ m 3117.0 2142.0   4 1071.0 0.687 1529.0, 6271.0 0.59
Crl:CD-1(ICR) f 5084.0 8689.0   8 3072.0 1.71 482.0, 26123.0 0.92
Crl:CD-1(ICR) m 2793.0 3813.0   8 1348.0 1.37 317.0, 9281.0 0.41
DBA/2J f 775.0 405.0   8 143.0 0.523 258.0, 1300.0 -0.75
DBA/2J m 669.0 537.0   8 190.0 0.803 246.0, 1751.0 -0.72
FVB/NJ f 7181.0 2100.0   8 743.0 0.293 4990.0, 10750.0 1.74
FVB/NJ m 6710.0 1727.0   8 611.0 0.257 4100.0, 9200.0 2.51
SJL/J f 1116.0 688.0   8 243.0 0.616 314.0, 2090.0 -0.62
SJL/J m 502.0 104.0   8 36.8 0.207 383.0, 693.0 -0.81
SPRET/EiJ f 668.0 289.0   7 109.0 0.432 249.0, 1162.0 -0.79
SPRET/EiJ m 697.0 389.0   7 147.0 0.559 333.0, 1214.0 -0.71
Tac:SW f 2123.0 1116.0   8 395.0 0.526 937.0, 4241.0 -0.23
Tac:SW m 1441.0 928.0   8 328.0 0.644 482.0, 3323.0 -0.31


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 417.5 806.6175 2007.9701 0.0
129S1/SvImJ m 763.875 806.6175 2354.3451 0.0
129S6/SvEvTac f 308.125 806.6175 1898.5951 0.0
129S6/SvEvTac m 418.375 806.6175 2008.8451 0.0
129X1/SvJ f 284.375 806.6175 1874.8451 0.0
129X1/SvJ m 298.75 806.6175 1889.2201 0.0
A/J f 806.375 806.6175 2396.8451 0.0
A/J m 963.375 806.6175 2553.8451 0.0
BALB/cByJ f 4256.75 806.6175 5847.2201 2666.2799
BALB/cByJ m 5173.875 806.6175 6764.3451 3583.4049
BALB/cJ f 6422.625 806.6175 8013.0951 4832.1549
BALB/cJ m 2868.5 806.6175 4458.9701 1278.0299
C3H/HeJ f 869.5714 862.3104 2569.8555 0.0
C3H/HeJ m 1729.5714 862.3104 3429.8555 29.2873
C57BL/6J f 6571.375 806.6175 8161.8451 4980.9049
C57BL/6J m 2152.75 806.6175 3743.2201 562.2799
CAST/EiJ f 3797.0 806.6175 5387.4701 2206.5299
CAST/EiJ m 3116.75 1140.7294 5366.0144 867.4856
Crl:CD-1(ICR) f 5084.125 806.6175 6674.5951 3493.6549
Crl:CD-1(ICR) m 2792.75 806.6175 4383.2201 1202.2799
DBA/2J f 775.375 806.6175 2365.8451 0.0
DBA/2J m 669.25 806.6175 2259.7201 0.0
FVB/NJ f 7180.75 806.6175 8771.2201 5590.2799
FVB/NJ m 6710.125 806.6175 8300.5951 5119.6549
SJL/J f 1115.625 806.6175 2706.0951 0.0
SJL/J m 502.375 806.6175 2092.8451 0.0
SPRET/EiJ f 667.8571 862.3104 2368.1412 0.0
SPRET/EiJ m 696.7143 862.3104 2396.9984 0.0
Tac:SW f 2123.375 806.6175 3713.8451 532.9049
Tac:SW m 1441.375 806.6175 3031.8451 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 590.6875 570.3647 1715.3197 0.0
129S6/SvEvTac both 363.25 570.3647 1487.8822 0.0
129X1/SvJ both 291.5625 570.3647 1416.1947 0.0
A/J both 884.875 570.3647 2009.5072 0.0
BALB/cByJ both 4715.3125 570.3647 5839.9447 3590.6803
BALB/cJ both 4645.5625 570.3647 5770.1947 3520.9303
C3H/HeJ both 1299.5714 609.7455 2501.8538 97.289
C57BL/6J both 4362.0625 570.3647 5486.6947 3237.4303
CAST/EiJ both 3456.875 698.5512 4834.2625 2079.4875
Crl:CD-1(ICR) both 3938.4375 570.3647 5063.0697 2813.8053
DBA/2J both 722.3125 570.3647 1846.9447 0.0
FVB/NJ both 6945.4375 570.3647 8070.0697 5820.8053
SJL/J both 809.0 570.3647 1933.6322 0.0
SPRET/EiJ both 682.2857 609.7455 1884.5681 0.0
Tac:SW both 1782.375 570.3647 2907.0072 657.7428




  GWAS USING LINEAR MIXED MODELS