Project measure / variable:   Maurer1   QT_iso10

ID, description, units MPD:33248   QT_iso10   interval QT   [ms]  isoprot 10mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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Maurer1 - interval QT isoprot 10mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means51.1   ms
Median of the strain means51.7   ms
SD of the strain means± 5.83
Coefficient of variation (CV)0.114
Min–max range of strain means39.0   –   63.8   ms
Mean sample size per strain9.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 6660.1996 302.7363 3.3701 < 0.0001
Residuals 199 17875.9419 89.8289


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 52.2 6.69   12 1.93 0.128 39.7, 61.3 0.19
A/J m 54.7 8.18   10 2.59 0.149 38.9, 65.2 0.62
AKR/J m 57.8 9.49   9 3.16 0.164 45.0, 74.8 1.15
BALB/cByJ m 51.7 11.4   9 3.79 0.22 23.0, 63.3 0.1
BALB/cJ m 54.6 20.3   8 7.16 0.371 25.6, 82.5 0.6
BTBR T+ Itpr3tf/J m 63.8 6.13   8 2.17 0.0961 56.6, 73.5 2.18
C3H/HeJ m 41.9 7.25   9 2.42 0.173 29.0, 52.0 -1.58
C3H/HeOuJ m 49.2 5.84   11 1.76 0.119 39.3, 58.0 -0.33
C57BL/6J m 46.4 6.27   7 2.37 0.135 39.8, 53.9 -0.81
C57BLKS/J m 56.3 9.46   10 2.99 0.168 43.6, 73.0 0.89
C58/J m 48.2 7.35   12 2.12 0.153 35.7, 61.5 -0.5
CBA/J m 46.2 4.33   10 1.37 0.0937 38.0, 53.0 -0.84
DBA/2J m 56.8 22.7   7 8.58 0.4 37.2, 104.0 0.98
FVB/NJ m 50.2 7.85   13 2.18 0.156 38.2, 65.7 -0.16
I/LnJ m 52.6 8.78   10 2.78 0.167 41.7, 70.0 0.26
KK/HlJ m 57.8 7.74   10 2.45 0.134 49.5, 72.8 1.15
LP/J m 53.7 8.03   8 2.84 0.15 39.4, 64.7 0.44
NOD/ShiLtJ m 48.3 1.53   10 0.485 0.0317 46.5, 51.2 -0.48
NZB/BlNJ m 43.0 6.26   7 2.37 0.146 36.2, 54.5 -1.39
PL/J m 50.0 13.6   10 4.29 0.271 30.1, 77.5 -0.19
SJL/J m 39.0 1.96   10 0.618 0.0501 34.7, 40.8 -2.07
SM/J m 54.8 4.39   13 1.22 0.0801 45.1, 62.6 0.63
SWR/J m 46.2 14.3   9 4.76 0.309 27.8, 76.4 -0.84


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 52.175 2.736 57.5703 46.7797
A/J m 54.75 2.9971 60.6602 48.8398
AKR/J m 57.8111 3.1593 64.0411 51.5812
BALB/cByJ m 51.7444 3.1593 57.9744 45.5145
BALB/cJ m 54.55 3.3509 61.1579 47.9421
BTBR T+ Itpr3tf/J m 63.8 3.3509 70.4079 57.1921
C3H/HeJ m 41.9222 3.1593 48.1522 35.6923
C3H/HeOuJ m 49.2364 2.8577 54.8716 43.6012
C57BL/6J m 46.3571 3.5823 53.4212 39.2931
C57BLKS/J m 56.33 2.9971 62.2402 50.4198
C58/J m 48.1833 2.736 53.5786 42.788
CBA/J m 46.22 2.9971 52.1302 40.3098
DBA/2J m 56.7857 3.5823 63.8498 49.7216
FVB/NJ m 50.2385 2.6287 55.4221 45.0548
I/LnJ m 52.64 2.9971 58.5502 46.7298
KK/HlJ m 57.77 2.9971 63.6802 51.8598
LP/J m 53.675 3.3509 60.2829 47.0671
NOD/ShiLtJ m 48.29 2.9971 54.2002 42.3798
NZB/BlNJ m 43.0 3.5823 50.0641 35.9359
PL/J m 50.0 2.9971 55.9102 44.0898
SJL/J m 39.04 2.9971 44.9502 33.1298
SM/J m 54.7846 2.6287 59.9682 49.601
SWR/J m 46.2444 3.1593 52.4744 40.0145




  GWAS USING LINEAR MIXED MODELS