Project measure / variable:   Maurer1   QT_at

ID, description, units MPD:33246   QT_at   interval QT   [ms]  atenolol 10mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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Maurer1 - interval QT atenolol 10mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means57.2   ms
Median of the strain means56.9   ms
SD of the strain means± 5.08
Coefficient of variation (CV)0.0887
Min–max range of strain means48.9   –   69.1   ms
Mean sample size per strain9.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 4646.3347 211.197 2.6319 0.0002
Residuals 196 15727.8256 80.244


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 57.2 11.0   13 3.06 0.193 39.5, 81.8 0.0
A/J m 52.9 4.29   10 1.36 0.0811 47.5, 61.2 -0.85
AKR/J m 61.6 4.68   7 1.77 0.0759 55.5, 69.1 0.86
BALB/cByJ m 58.0 6.85   8 2.42 0.118 50.6, 70.8 0.16
BALB/cJ m 56.7 6.49   10 2.05 0.114 44.2, 65.6 -0.1
BTBR T+ Itpr3tf/J m 58.0 3.56   9 1.19 0.0614 54.2, 63.8 0.16
C3H/HeJ m 52.0 5.33   8 1.88 0.102 40.4, 56.2 -1.03
C3H/HeOuJ m 63.3 4.71   9 1.57 0.0745 58.4, 71.9 1.2
C57BL/6J m 53.3 2.14   9 0.714 0.0402 50.0, 55.5 -0.77
C57BLKS/J m 63.5 7.22   9 2.41 0.114 56.1, 77.9 1.24
C58/J m 57.0 4.23   12 1.22 0.0743 50.3, 63.0 -0.04
CBA/J m 50.4 10.4   6 4.24 0.206 39.5, 69.0 -1.34
DBA/2J m 69.1 16.6   6 6.79 0.241 44.8, 91.5 2.34
FVB/NJ m 54.3 4.09   14 1.09 0.0754 49.4, 62.5 -0.57
I/LnJ m 65.9 30.5   9 10.2 0.463 22.0, 137.0 1.71
KK/HlJ m 55.6 4.47   9 1.49 0.0803 48.7, 64.5 -0.32
LP/J m 50.9 3.11   10 0.983 0.061 47.0, 55.0 -1.24
NOD/ShiLtJ m 55.0 3.39   10 1.07 0.0616 49.9, 59.6 -0.44
NZB/BlNJ m 56.9 8.26   9 2.75 0.145 47.6, 75.1 -0.06
PL/J m 56.1 6.77   10 2.14 0.121 44.4, 67.7 -0.22
SJL/J m 48.9 7.99   9 2.66 0.163 29.9, 57.2 -1.64
SM/J m 61.5 3.74   12 1.08 0.0608 53.7, 68.7 0.84
SWR/J m 57.8 7.51   11 2.26 0.13 48.4, 72.3 0.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 57.2385 2.4845 62.1382 52.3387
A/J m 52.89 2.8327 58.4766 47.3034
AKR/J m 61.6429 3.3858 68.3201 54.9656
BALB/cByJ m 57.9875 3.1671 64.2335 51.7415
BALB/cJ m 56.68 2.8327 62.2666 51.0934
BTBR T+ Itpr3tf/J m 58.0333 2.986 63.9221 52.1446
C3H/HeJ m 52.025 3.1671 58.271 45.779
C3H/HeOuJ m 63.2778 2.986 69.1665 57.389
C57BL/6J m 53.2889 2.986 59.1776 47.4001
C57BLKS/J m 63.5333 2.986 69.4221 57.6446
C58/J m 56.9667 2.5859 62.0665 51.8669
CBA/J m 50.3833 3.657 57.5955 43.1711
DBA/2J m 69.1 3.657 76.3122 61.8878
FVB/NJ m 54.2857 2.3941 59.0072 49.5642
I/LnJ m 65.9333 2.986 71.8221 60.0446
KK/HlJ m 55.6 2.986 61.4887 49.7113
LP/J m 50.93 2.8327 56.5166 45.3434
NOD/ShiLtJ m 55.04 2.8327 60.6266 49.4534
NZB/BlNJ m 56.8667 2.986 62.7554 50.9779
PL/J m 56.08 2.8327 61.6666 50.4934
SJL/J m 48.8556 2.986 54.7443 42.9668
SM/J m 61.5417 2.5859 66.6415 56.4419
SWR/J m 57.8 2.7009 63.1266 52.4734




  GWAS USING LINEAR MIXED MODELS