Project measure / variable:   Svenson3   F8

ID, description, units MPD:27342   F8   clotting factor VIII, percent of normal human value   [%]  
Data set, strains Svenson3   B6.PWD consomic w/par   22 strains     sex: both     age: 6wks
Procedure coagulation test
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  STRAIN COMPARISON PLOT
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Svenson3 - clotting factor VIII, percent of normal human value



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means118   % 157   %
Median of the strain means108   % 163   %
SD of the strain means± 32.8 ± 41.3
Coefficient of variation (CV)0.279 0.263
Min–max range of strain means67.4   –   168   % 74.0   –   232   %
Mean sample size per strain8.5   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 129744.3919 129744.3919 61.4701 < 0.0001
strain 20 335529.0433 16776.4522 7.9483 < 0.0001
sex:strain 20 49456.0224 2472.8011 1.1716 0.2775
Residuals 306 645871.3219 2110.6906


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 161.0 35.1   6 14.3 0.218 110.0, 202.0 1.32
B6.PWD-Chr1 m 232.0 21.7   3 12.5 0.0934 210.0, 254.0 1.82
B6.PWD-Chr11.1 f 94.2 32.3   9 10.8 0.343 42.4, 144.0 -0.71
B6.PWD-Chr11.1 m 163.0 53.7   8 19.0 0.331 94.6, 259.0 0.15
B6.PWD-Chr11.2 f 98.3 41.5   9 13.8 0.422 34.9, 180.0 -0.59
B6.PWD-Chr11.2 m 143.0 69.1   8 24.4 0.484 64.1, 221.0 -0.33
B6.PWD-Chr11.3 f 93.3 29.0   8 10.3 0.311 72.2, 160.0 -0.74
B6.PWD-Chr11.3 m 112.0 15.1   8 5.33 0.135 92.5, 131.0 -1.08
B6.PWD-Chr12 f 69.8 8.92   6 3.64 0.128 58.8, 82.5 -1.45
B6.PWD-Chr12 m 75.8 11.1   7 4.21 0.147 57.0, 92.6 -1.96
B6.PWD-Chr14 f 101.0 39.5   9 13.2 0.39 61.5, 159.0 -0.5
B6.PWD-Chr14 m 133.0 67.9   8 24.0 0.512 67.2, 232.0 -0.57
B6.PWD-Chr15 f 132.0 34.3   8 12.1 0.26 86.5, 201.0 0.44
B6.PWD-Chr15 m 187.0 31.7   7 12.0 0.169 143.0, 229.0 0.73
B6.PWD-Chr16 f 156.0 39.0   9 13.0 0.25 111.0, 233.0 1.17
B6.PWD-Chr16 m 182.0 37.4   8 13.2 0.206 121.0, 232.0 0.61
B6.PWD-Chr17 f 67.4 18.2   8 6.42 0.27 33.1, 90.1 -1.53
B6.PWD-Chr17 m 114.0 69.4   9 23.1 0.61 42.7, 238.0 -1.03
B6.PWD-Chr18 f 153.0 22.9   11 6.92 0.15 122.0, 195.0 1.08
B6.PWD-Chr18 m 193.0 52.7   9 17.6 0.272 92.6, 273.0 0.88
B6.PWD-Chr19 f 168.0 44.3   8 15.7 0.263 115.0, 257.0 1.54
B6.PWD-Chr19 m 148.0 60.6   10 19.2 0.409 86.9, 286.0 -0.21
B6.PWD-Chr2 f 106.0 42.8   9 14.3 0.404 71.8, 184.0 -0.35
B6.PWD-Chr2 m 144.0 51.7   10 16.4 0.359 61.7, 231.0 -0.31
B6.PWD-Chr3 f 81.4 14.2   5 6.33 0.174 65.3, 96.0 -1.1
B6.PWD-Chr3 m 129.0 21.5   5 9.63 0.167 103.0, 161.0 -0.67
B6.PWD-Chr5 f 137.0 82.1   7 31.0 0.597 64.0, 288.0 0.59
B6.PWD-Chr5 m 209.0 78.2   12 22.6 0.374 71.2, 358.0 1.27
B6.PWD-Chr6 f 154.0 36.9   10 11.7 0.241 76.5, 205.0 1.11
B6.PWD-Chr6 m 185.0 63.9   7 24.2 0.345 80.6, 234.0 0.69
B6.PWD-Chr9 f 71.6 17.0   6 6.96 0.238 51.2, 93.5 -1.4
B6.PWD-Chr9 m 74.0 19.7   3 11.3 0.266 58.9, 96.2 -2.0
B6.PWD-ChrX.1 f 145.0 64.0   11 19.3 0.443 58.3, 301.0 0.84
B6.PWD-ChrX.1 m 170.0 66.6   12 19.2 0.392 49.7, 285.0 0.32
B6.PWD-ChrX.3 f 139.0 28.5   12 8.23 0.206 104.0, 200.0 0.65
B6.PWD-ChrX.3 m 207.0 30.9   8 10.9 0.149 176.0, 268.0 1.22
B6.PWD-ChrY f 108.0 40.1   9 13.4 0.372 72.8, 174.0 -0.29
B6.PWD-ChrY m 154.0 24.8   8 8.76 0.16 111.0, 192.0 -0.07
B6.PWD-mt f 93.2 33.7   9 11.2 0.362 58.6, 158.0 -0.74
B6.PWD-mt m 170.0 32.6   9 10.9 0.192 117.0, 219.0 0.32
C57BL/6J f 139.0 31.4   10 9.92 0.225 93.7, 175.0 0.65
C57BL/6J m 166.0 48.5   10 15.3 0.291 94.9, 270.0 0.23


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 161.2 18.7558 198.1068 124.2932
B6.PWD-Chr1 m 232.4333 26.5248 284.6274 180.2393
B6.PWD-Chr11.1 f 94.2111 15.3141 124.3454 64.0769
B6.PWD-Chr11.1 m 162.5125 16.243 194.4747 130.5503
B6.PWD-Chr11.2 f 98.3333 15.3141 128.4676 68.1991
B6.PWD-Chr11.2 m 142.7 16.243 174.6622 110.7378
B6.PWD-Chr11.3 f 93.2625 16.243 125.2247 61.3003
B6.PWD-Chr11.3 m 111.9625 16.243 143.9247 80.0003
B6.PWD-Chr12 f 69.8 18.7558 106.7068 32.8932
B6.PWD-Chr12 m 75.7857 17.3645 109.9547 41.6167
B6.PWD-Chr14 f 101.3222 15.3141 131.4565 71.188
B6.PWD-Chr14 m 132.6625 16.243 164.6247 100.7003
B6.PWD-Chr15 f 131.5625 16.243 163.5247 99.6003
B6.PWD-Chr15 m 187.4429 17.3645 221.6119 153.2738
B6.PWD-Chr16 f 155.9 15.3141 186.0342 125.7658
B6.PWD-Chr16 m 181.7375 16.243 213.6997 149.7753
B6.PWD-Chr17 f 67.4 16.243 99.3622 35.4378
B6.PWD-Chr17 m 113.7667 15.3141 143.9009 83.6324
B6.PWD-Chr18 f 153.3818 13.8521 180.6393 126.1244
B6.PWD-Chr18 m 193.4667 15.3141 223.6009 163.3324
B6.PWD-Chr19 f 168.4875 16.243 200.4497 136.5253
B6.PWD-Chr19 m 147.91 14.5282 176.4978 119.3222
B6.PWD-Chr2 f 105.9333 15.3141 136.0676 75.7991
B6.PWD-Chr2 m 144.2 14.5282 172.7878 115.6122
B6.PWD-Chr3 f 81.4 20.546 121.8293 40.9707
B6.PWD-Chr3 m 128.72 20.546 169.1493 88.2907
B6.PWD-Chr5 f 137.4429 17.3645 171.6119 103.2738
B6.PWD-Chr5 m 209.1917 13.2624 235.2887 183.0946
B6.PWD-Chr6 f 153.51 14.5282 182.0978 124.9222
B6.PWD-Chr6 m 185.2 17.3645 219.369 151.031
B6.PWD-Chr9 f 71.65 18.7558 108.5568 34.7432
B6.PWD-Chr9 m 73.9667 26.5248 126.1607 21.7726
B6.PWD-ChrX.1 f 144.6364 13.8521 171.8938 117.3789
B6.PWD-ChrX.1 m 169.9833 13.2624 196.0804 143.8863
B6.PWD-ChrX.3 f 138.675 13.2624 164.772 112.578
B6.PWD-ChrX.3 m 207.45 16.243 239.4122 175.4878
B6.PWD-ChrY f 107.7667 15.3141 137.9009 77.6324
B6.PWD-ChrY m 154.5 16.243 186.4622 122.5378
B6.PWD-mt f 93.2333 15.3141 123.3676 63.0991
B6.PWD-mt m 169.6111 15.3141 199.7454 139.4769
C57BL/6J f 139.43 14.5282 168.0178 110.8422
C57BL/6J m 166.49 14.5282 195.0778 137.9022


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 196.8167 16.243 228.7789 164.8545
B6.PWD-Chr11.1 both 128.3618 11.162 150.3257 106.3979
B6.PWD-Chr11.2 both 120.5167 11.162 142.4806 98.5528
B6.PWD-Chr11.3 both 102.6125 11.4856 125.2132 80.0118
B6.PWD-Chr12 both 72.7929 12.78 97.9406 47.6451
B6.PWD-Chr14 both 116.9924 11.162 138.9563 95.0284
B6.PWD-Chr15 both 159.5027 11.8887 182.8966 136.1088
B6.PWD-Chr16 both 168.8187 11.162 190.7827 146.8548
B6.PWD-Chr17 both 90.5833 11.162 112.5472 68.6194
B6.PWD-Chr18 both 173.4242 10.3248 193.7407 153.1077
B6.PWD-Chr19 both 158.1987 10.8962 179.6396 136.7579
B6.PWD-Chr2 both 125.0667 10.5545 145.8353 104.2981
B6.PWD-Chr3 both 105.06 14.5282 133.6478 76.4722
B6.PWD-Chr5 both 173.3173 10.9249 194.8148 151.8197
B6.PWD-Chr6 both 169.355 11.3203 191.6305 147.0795
B6.PWD-Chr9 both 72.8083 16.243 104.7705 40.8461
B6.PWD-ChrX.1 both 157.3098 9.5887 176.178 138.4417
B6.PWD-ChrX.3 both 173.0625 10.4848 193.694 152.431
B6.PWD-ChrY both 131.1333 11.162 153.0972 109.1694
B6.PWD-mt both 131.4222 10.8287 152.7303 110.1141
C57BL/6J both 152.96 10.273 173.1747 132.7453




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA