MPD: Project measure / variable: Xing1 HR

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Visualization Options Least squares means Alphabetical order Strains on X-axis Individual points

Xing1 - heart rate at age 6mo

Measure Summary	Female	Male
Number of strains tested	28 strains	27 strains
Mean of the strain means	731 n/min	747 n/min
Median of the strain means	728 n/min	754 n/min
SD of the strain means	± 31.0	± 35.2
Coefficient of variation (CV)	0.0425	0.0472
Min–max range of strain means	672 – 801 n/min	657 – 808 n/min
Mean sample size per strain	7.5 mice	7.4 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
sex	1	24690.2073	24690.2073	14.5923	0.0002
strain	26	353604.593	13600.1767	8.0379	< 0.0001
sex:strain	26	71856.7763	2763.7222	1.6334	0.0281
Residuals	348	588818.7643	1692.0079

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Min, Max	Z score
129S1/SvImJ	f	710.0	44.4	8	15.7	0.0626	642.0, 773.0	-0.67
129S1/SvImJ	m	753.0	53.7	7	20.3	0.0713	679.0, 823.0	0.18
A/J	f	723.0	72.9	8	25.8	0.101	627.0, 799.0	-0.25
A/J	m	703.0	86.1	8	30.5	0.122	555.0, 804.0	-1.24
AKR/J	f	782.0	14.9	8	5.26	0.019	759.0, 805.0	1.65
AKR/J	m	766.0	20.0	7	7.56	0.0261	737.0, 787.0	0.55
BALB/cByJ	f	697.0	24.2	7	9.15	0.0348	660.0, 728.0	-1.09
BALB/cByJ	m	673.0	20.9	8	7.39	0.0311	640.0, 702.0	-2.09
BTBR T⁺ Itpr3^tf/J	f	722.0	29.1	6	11.9	0.0403	681.0, 748.0	-0.28
BUB/BnJ	f	791.0	25.3	7	9.56	0.032	754.0, 817.0	1.94
BUB/BnJ	m	787.0	20.1	7	7.59	0.0255	755.0, 809.0	1.14
C3H/HeJ	f	744.0	72.4	8	25.6	0.0972	625.0, 812.0	0.43
C3H/HeJ	m	808.0	25.5	7	9.64	0.0316	770.0, 841.0	1.74
C57BL/10J	f	711.0	62.7	7	23.7	0.0882	625.0, 787.0	-0.64
C57BL/10J	m	760.0	18.3	8	6.48	0.0241	733.0, 787.0	0.38
C57BL/6J	f	735.0	10.6	8	3.74	0.0144	721.0, 754.0	0.14
C57BL/6J	m	754.0	15.9	8	5.63	0.0211	732.0, 778.0	0.21
C57BLKS/J	f	678.0	46.8	8	16.5	0.0691	571.0, 722.0	-1.7
C57BLKS/J	m	720.0	36.0	7	13.6	0.05	672.0, 764.0	-0.76
C57BR/cdJ	f	729.0	22.9	7	8.65	0.0314	693.0, 750.0	-0.06
C57BR/cdJ	m	746.0	22.9	7	8.65	0.0307	730.0, 791.0	-0.02
C57L/J	f	738.0	20.9	8	7.37	0.0282	700.0, 766.0	0.23
C57L/J	m	734.0	26.7	8	9.44	0.0364	686.0, 763.0	-0.36
CBA/J	f	745.0	43.5	7	16.4	0.0584	657.0, 792.0	0.46
CBA/J	m	768.0	18.8	8	6.65	0.0245	746.0, 796.0	0.6
DBA/2J	f	712.0	15.6	8	5.53	0.022	686.0, 733.0	-0.6
DBA/2J	m	733.0	34.7	8	12.3	0.0473	662.0, 772.0	-0.39
FVB/NJ	f	770.0	32.7	8	11.5	0.0424	727.0, 816.0	1.27
FVB/NJ	m	781.0	20.7	7	7.83	0.0265	756.0, 813.0	0.97
KK/HlJ	f	728.0	17.4	8	6.14	0.0239	693.0, 749.0	-0.09
KK/HlJ	m	747.0	27.9	8	9.87	0.0374	700.0, 789.0	0.01
LP/J	f	726.0	50.6	6	20.7	0.0696	664.0, 775.0	-0.15
LP/J	m	777.0	49.3	8	17.4	0.0635	707.0, 852.0	0.86
MRL/MpJ	f	726.0	27.0	6	11.0	0.0372	684.0, 752.0	-0.15
MRL/MpJ	m	757.0	25.9	8	9.16	0.0342	705.0, 780.0	0.29
NOD.B10Sn-H2^b/J	f	801.0	33.4	6	13.6	0.0416	761.0, 851.0	2.27
NOD.B10Sn-H2^b/J	m	785.0	25.2	4	12.6	0.032	758.0, 816.0	1.09
NON/ShiLtJ	f	714.0	18.7	8	6.62	0.0262	686.0, 746.0	-0.54
NON/ShiLtJ	m	707.0	29.8	8	10.5	0.0422	672.0, 755.0	-1.13
NZO/HlLtJ	f	737.0	42.3	8	15.0	0.0575	645.0, 772.0	0.2
NZO/HlLtJ	m	761.0	21.5	7	8.14	0.0283	741.0, 797.0	0.4
NZW/LacJ	f	688.0	72.5	8	25.6	0.105	563.0, 796.0	-1.38
NZW/LacJ	m	709.0	77.6	7	29.3	0.109	563.0, 775.0	-1.07
P/J	f	751.0	19.2	5	8.58	0.0255	720.0, 768.0	0.65
P/J	m	770.0	17.1	7	6.45	0.0222	744.0, 797.0	0.66
PL/J	f	744.0	36.5	10	11.6	0.0492	688.0, 788.0	0.43
PL/J	m	742.0	36.5	5	16.3	0.0493	696.0, 780.0	-0.13
RIIIS/J	f	672.0	98.4	8	34.8	0.146	529.0, 782.0	-1.89
RIIIS/J	m	657.0	59.8	7	22.6	0.0911	567.0, 750.0	-2.55
SJL/J	f	699.0	44.5	8	15.7	0.0636	642.0, 763.0	-1.02
SJL/J	m	778.0	16.7	8	5.9	0.0215	758.0, 808.0	0.89
SM/J	f	744.0	27.3	8	9.65	0.0367	699.0, 774.0	0.43
SM/J	m	764.0	12.9	8	4.56	0.0169	744.0, 778.0	0.49
SWR/J	f	743.0	39.5	8	14.0	0.0532	692.0, 803.0	0.4
SWR/J	m	722.0	51.1	8	18.1	0.0708	643.0, 816.0	-0.7

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	f	709.875	14.5431	738.4784	681.2716
129S1/SvImJ	m	753.1429	15.5472	783.7212	722.5646
A/J	f	723.25	14.5431	751.8534	694.6466
A/J	m	703.25	14.5431	731.8534	674.6466
AKR/J	f	781.5	14.5431	810.1034	752.8966
AKR/J	m	766.1429	15.5472	796.7212	735.5646
BALB/cByJ	f	696.8571	15.5472	727.4354	666.2788
BALB/cByJ	m	672.75	14.5431	701.3534	644.1466
BUB/BnJ	f	790.7143	15.5472	821.2926	760.136
BUB/BnJ	m	787.2857	15.5472	817.864	756.7074
C3H/HeJ	f	744.375	14.5431	772.9784	715.7716
C3H/HeJ	m	807.8571	15.5472	838.4354	777.2788
C57BL/10J	f	711.4286	15.5472	742.0069	680.8503
C57BL/10J	m	760.125	14.5431	788.7284	731.5216
C57BL/6J	f	735.25	14.5431	763.8534	706.6466
C57BL/6J	m	753.5	14.5431	782.1034	724.8966
C57BLKS/J	f	677.625	14.5431	706.2284	649.0216
C57BLKS/J	m	720.0	15.5472	750.5783	689.4217
C57BR/cdJ	f	728.8571	15.5472	759.4354	698.2788
C57BR/cdJ	m	745.8571	15.5472	776.4354	715.2788
C57L/J	f	738.5	14.5431	767.1034	709.8966
C57L/J	m	734.25	14.5431	762.8534	705.6466
CBA/J	f	744.7143	15.5472	775.2926	714.136
CBA/J	m	768.25	14.5431	796.8534	739.6466
DBA/2J	f	711.5	14.5431	740.1034	682.8966
DBA/2J	m	733.25	14.5431	761.8534	704.6466
FVB/NJ	f	770.5	14.5431	799.1034	741.8966
FVB/NJ	m	780.7143	15.5472	811.2926	750.136
KK/HlJ	f	727.625	14.5431	756.2284	699.0216
KK/HlJ	m	746.875	14.5431	775.4784	718.2716
LP/J	f	726.3333	16.7929	759.3617	693.305
LP/J	m	776.625	14.5431	805.2284	748.0216
MRL/MpJ	f	726.3333	16.7929	759.3617	693.305
MRL/MpJ	m	757.125	14.5431	785.7284	728.5216
NOD.B10Sn-H2^b/J	f	801.1667	16.7929	834.195	768.1383
NOD.B10Sn-H2^b/J	m	785.0	20.567	825.4513	744.5487
NON/ShiLtJ	f	714.375	14.5431	742.9784	685.7716
NON/ShiLtJ	m	707.25	14.5431	735.8534	678.6466
NZO/HlLtJ	f	736.625	14.5431	765.2284	708.0216
NZO/HlLtJ	m	761.0	15.5472	791.5783	730.4217
NZW/LacJ	f	687.5	14.5431	716.1034	658.8966
NZW/LacJ	m	709.4286	15.5472	740.0069	678.8503
P/J	f	751.2	18.3957	787.3807	715.0193
P/J	m	769.5714	15.5472	800.1497	738.9931
PL/J	f	743.5	13.0077	769.0836	717.9164
PL/J	m	742.0	18.3957	778.1807	705.8193
RIIIS/J	f	671.625	14.5431	700.2284	643.0216
RIIIS/J	m	656.5714	15.5472	687.1497	625.9931
SJL/J	f	698.75	14.5431	727.3534	670.1466
SJL/J	m	777.875	14.5431	806.4784	749.2716
SM/J	f	744.0	14.5431	772.6034	715.3966
SM/J	m	763.625	14.5431	792.2284	735.0216
SWR/J	f	742.75	14.5431	771.3534	714.1466
SWR/J	m	722.375	14.5431	750.9784	693.7716

LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	both	731.5089	10.6444	752.4445	710.5734
A/J	both	713.25	10.2835	733.4756	693.0244
AKR/J	both	773.8214	10.6444	794.757	752.8859
BALB/cByJ	both	684.8036	10.6444	705.7391	663.868
BUB/BnJ	both	789.0	10.9935	810.6221	767.3779
C3H/HeJ	both	776.1161	10.6444	797.0516	755.1805
C57BL/10J	both	735.7768	10.6444	756.7123	714.8413
C57BL/6J	both	744.375	10.2835	764.6006	724.1494
C57BLKS/J	both	698.8125	10.6444	719.748	677.877
C57BR/cdJ	both	737.3571	10.9935	758.9793	715.735
C57L/J	both	736.375	10.2835	756.6006	716.1494
CBA/J	both	756.4821	10.6444	777.4177	735.5466
DBA/2J	both	722.375	10.2835	742.6006	702.1494
FVB/NJ	both	775.6071	10.6444	796.5427	754.6716
KK/HlJ	both	737.25	10.2835	757.4756	717.0244
LP/J	both	751.4792	11.1075	773.3254	729.633
MRL/MpJ	both	741.7292	11.1075	763.5754	719.883
NOD.B10Sn-H2^b/J	both	793.0833	13.2759	819.1945	766.9721
NON/ShiLtJ	both	710.8125	10.2835	731.0381	690.5869
NZO/HlLtJ	both	748.8125	10.6444	769.748	727.877
NZW/LacJ	both	698.4643	10.6444	719.3998	677.5288
P/J	both	760.3857	12.0428	784.0716	736.6999
PL/J	both	742.75	11.265	764.9061	720.5939
RIIIS/J	both	664.0982	10.6444	685.0337	643.1627
SJL/J	both	738.3125	10.2835	758.5381	718.0869
SM/J	both	753.8125	10.2835	774.0381	733.5869
SWR/J	both	732.5625	10.2835	752.7881	712.3369

INDIVIDUAL ANIMAL VALUES

Click here to view individual animal values

GWAS USING LINEAR MIXED MODELS

ID, description, units	MPD:24901 HR_M06 heart rate [n/min] at age 6mo
Data set, strains	Xing1 inbred 28 strains sex: both age: 26wks
Procedure	ECG
Ontology mappings	MA:0000072 heart MP:0001629 abnormal heart rate VT:2000009 heart pumping trait