Project measure / variable:   Yuan3   ALT_M18

ID, description, units MPD:24403   ALT_M18   alanine transaminase (plasma ALT)   [IU/L]  at age 18mo  
Data set, strains Yuan3   inbred   29 strains     sex: both     age: 78wks
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  STRAIN COMPARISON PLOT
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Yuan3 - alanine transaminase (plasma ALT) at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains25 strains
Mean of the strain means57.9   IU/L 59.7   IU/L
Median of the strain means48.3   IU/L 49.4   IU/L
SD of the strain means± 31.5 ± 32.5
Coefficient of variation (CV)0.544 0.544
Min–max range of strain means28.0   –   156   IU/L 32.2   –   179   IU/L
Mean sample size per strain6.5   mice 5.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2073.063 2073.063 1.8374 0.1765
strain 23 254970.2757 11085.6642 9.8256 < 0.0001
sex:strain 23 27127.0664 1179.4377 1.0454 0.4091
Residuals 249 280933.1369 1128.2455


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 29.0 10.1   4 5.05 0.348 21.0, 42.0 -0.92
129S1/SvImJ m 32.8 7.41   6 3.03 0.226 22.0, 44.0 -0.83
A/J f 84.7 30.1   6 12.3 0.356 59.0, 143.0 0.85
BALB/cByJ f 48.1 11.8   7 4.46 0.245 35.0, 71.0 -0.31
BALB/cByJ m 73.0 53.2   5 23.8 0.728 39.0, 165.0 0.41
BTBR T+ Itpr3tf/J f 28.0 6.0   8 2.12 0.214 20.0, 39.0 -0.95
BTBR T+ Itpr3tf/J m 40.0 6.82   5 3.05 0.17 36.0, 52.0 -0.61
BUB/BnJ f 61.9 14.8   8 5.24 0.239 47.0, 93.0 0.13
BUB/BnJ m 44.5 12.9   6 5.26 0.29 24.0, 60.0 -0.47
C3H/HeJ f 47.5 8.35   8 2.95 0.176 30.0, 59.0 -0.33
C3H/HeJ m 49.4 39.2   7 14.8 0.793 26.0, 134.0 -0.32
C57BL/10J f 61.8 7.19   5 3.22 0.116 50.0, 68.0 0.12
C57BL/10J m 65.0 0.0   1   0.0 0.0 65.0, 65.0 0.16
C57BL/6J f 61.3 63.4   7 24.0 1.03 35.0, 205.0 0.11
C57BL/6J m 47.7 24.7   7 9.34 0.518 28.0, 101.0 -0.37
C57BLKS/J f 46.4 15.3   7 5.79 0.33 21.0, 72.0 -0.36
C57BR/cdJ f 65.0 17.5   8 6.2 0.27 36.0, 91.0 0.23
C57BR/cdJ m 67.8 12.9   6 5.26 0.19 45.0, 82.0 0.25
C57L/J f 60.0 13.1   7 4.96 0.219 50.0, 87.0 0.07
C57L/J m 52.5 8.36   6 3.41 0.159 41.0, 62.0 -0.22
CBA/J f 37.9 14.0   8 4.95 0.369 25.0, 65.0 -0.63
CBA/J m 44.8 30.6   6 12.5 0.683 25.0, 106.0 -0.46
DBA/2J f 37.3 13.3   7 5.04 0.358 30.0, 67.0 -0.65
DBA/2J m 37.5 14.1   6 5.75 0.376 27.0, 63.0 -0.68
FVB/NJ f 73.1 17.9   8 6.31 0.244 57.0, 113.0 0.48
KK/HlJ f 41.0 6.08   3 3.51 0.148 37.0, 48.0 -0.54
KK/HlJ m 68.7 61.9   6 25.3 0.902 37.0, 194.0 0.28
LP/J f 31.5 6.56   4 3.28 0.208 26.0, 41.0 -0.84
LP/J m 47.2 15.9   5 7.12 0.337 30.0, 72.0 -0.38
MRL/MpJ f 152.0 136.0   6 55.3 0.894 45.0, 340.0 2.99
MRL/MpJ m 179.0 95.6   7 36.1 0.535 92.0, 365.0 3.67
NOD.B10Sn-H2b/J f 30.3 8.02   6 3.27 0.264 21.0, 44.0 -0.88
NOD.B10Sn-H2b/J m 34.0 4.0   6 1.63 0.118 27.0, 39.0 -0.79
NON/ShiLtJ f 39.6 17.2   14 4.59 0.434 22.0, 91.0 -0.58
NON/ShiLtJ m 32.2 12.8   6 5.23 0.398 21.0, 53.0 -0.85
NZO/HlLtJ f 48.3 21.0   3 12.1 0.434 32.0, 72.0 -0.3
NZW/LacJ f 36.7 21.4   6 8.75 0.585 20.0, 78.0 -0.67
NZW/LacJ m 33.7 5.15   7 1.95 0.153 28.0, 42.0 -0.8
P/J f 156.0 71.4   2   50.5 0.459 105.0, 206.0 3.12
P/J m 61.5 21.6   4 10.8 0.351 38.0, 86.0 0.06
PL/J f 59.2 11.6   6 4.74 0.196 41.0, 77.0 0.04
PL/J m 52.6 6.8   5 3.04 0.129 44.0, 61.0 -0.22
PWD/PhJ f 80.6 24.0   8 8.5 0.298 52.0, 114.0 0.72
PWD/PhJ m 95.3 40.3   7 15.2 0.423 45.0, 151.0 1.1
RIIIS/J f 34.1 2.54   7 0.962 0.0745 31.0, 38.0 -0.76
RIIIS/J m 33.2 11.4   6 4.66 0.345 21.0, 54.0 -0.81
SJL/J f 57.7 22.4   7 8.46 0.388 38.0, 105.0 -0.01
SJL/J m 50.3 17.6   3 10.2 0.35 36.0, 70.0 -0.29
SM/J f 32.4 4.83   7 1.82 0.149 26.0, 39.0 -0.81
SM/J m 43.2 18.8   4 9.42 0.436 23.0, 65.0 -0.51
SWR/J f 48.9 14.0   7 5.3 0.287 26.0, 67.0 -0.28
SWR/J m 106.0 75.7   2   53.5 0.71 53.0, 160.0 1.43
WSB/EiJ f 88.0 17.4   8 6.16 0.198 66.0, 112.0 0.96
WSB/EiJ m 99.8 32.1   6 13.1 0.322 67.0, 157.0 1.24


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 29.0 16.7947 62.0777 0.0
129S1/SvImJ m 32.8333 13.7128 59.8412 5.8255
BALB/cByJ f 48.1429 12.6956 73.1473 23.1384
BALB/cByJ m 73.0 15.0216 102.5856 43.4144
BTBR T+ Itpr3tf/J f 28.0 11.8756 51.3895 4.6105
BTBR T+ Itpr3tf/J m 40.0 15.0216 69.5856 10.4144
BUB/BnJ f 61.875 11.8756 85.2645 38.4855
BUB/BnJ m 44.5 13.7128 71.5079 17.4921
C3H/HeJ f 47.5 11.8756 70.8895 24.1105
C3H/HeJ m 49.4286 12.6956 74.433 24.4241
C57BL/6J f 61.2857 12.6956 86.2901 36.2813
C57BL/6J m 47.7143 12.6956 72.7187 22.7099
C57BR/cdJ f 65.0 11.8756 88.3895 41.6105
C57BR/cdJ m 67.8333 13.7128 94.8412 40.8255
C57L/J f 60.0 12.6956 85.0044 34.9956
C57L/J m 52.5 13.7128 79.5079 25.4921
CBA/J f 37.875 11.8756 61.2645 14.4855
CBA/J m 44.8333 13.7128 71.8412 17.8255
DBA/2J f 37.2857 12.6956 62.2901 12.2813
DBA/2J m 37.5 13.7128 64.5079 10.4921
KK/HlJ f 41.0 19.3928 79.1949 2.8051
KK/HlJ m 68.6667 13.7128 95.6745 41.6588
LP/J f 31.5 16.7947 64.5777 0.0
LP/J m 47.2 15.0216 76.7856 17.6144
MRL/MpJ f 151.6667 13.7128 178.6745 124.6588
MRL/MpJ m 178.7143 12.6956 203.7187 153.7099
NOD.B10Sn-H2b/J f 30.3333 13.7128 57.3412 3.3255
NOD.B10Sn-H2b/J m 34.0 13.7128 61.0079 6.9921
NON/ShiLtJ f 39.5714 8.9771 57.2522 21.8906
NON/ShiLtJ m 32.1667 13.7128 59.1745 5.1588
NZW/LacJ f 36.6667 13.7128 63.6745 9.6588
NZW/LacJ m 33.7143 12.6956 58.7187 8.7099
P/J f 155.5 23.7513 202.279 108.721
P/J m 61.5 16.7947 94.5777 28.4223
PL/J f 59.1667 13.7128 86.1745 32.1588
PL/J m 52.6 15.0216 82.1856 23.0144
PWD/PhJ f 80.625 11.8756 104.0145 57.2355
PWD/PhJ m 95.2857 12.6956 120.2901 70.2813
RIIIS/J f 34.1429 12.6956 59.1473 9.1384
RIIIS/J m 33.1667 13.7128 60.1745 6.1588
SJL/J f 57.7143 12.6956 82.7187 32.7099
SJL/J m 50.3333 19.3928 88.5282 12.1384
SM/J f 32.4286 12.6956 57.433 7.4241
SM/J m 43.25 16.7947 76.3277 10.1723
SWR/J f 48.8571 12.6956 73.8616 23.8527
SWR/J m 106.5 23.7513 153.279 59.721
WSB/EiJ f 88.0 11.8756 111.3895 64.6105
WSB/EiJ m 99.8333 13.7128 126.8412 72.8255


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 30.9167 10.8409 52.2683 9.5651
BALB/cByJ both 60.5714 9.834 79.9398 41.2031
BTBR T+ Itpr3tf/J both 34.0 9.5744 52.8572 15.1428
BUB/BnJ both 53.1875 9.0702 71.0515 35.3235
C3H/HeJ both 48.4643 8.6921 65.5836 31.3449
C57BL/6J both 54.5 8.9771 72.1808 36.8192
C57BR/cdJ both 66.4167 9.0702 84.2807 48.5526
C57L/J both 56.25 9.3437 74.6528 37.8472
CBA/J both 41.3542 9.0702 59.2182 23.4901
DBA/2J both 37.3929 9.3437 55.7956 18.9901
KK/HlJ both 54.8333 11.8756 78.2228 31.4438
LP/J both 39.35 11.2662 61.5392 17.1608
MRL/MpJ both 165.1905 9.3437 183.5932 146.7877
NOD.B10Sn-H2b/J both 32.1667 9.6964 51.2641 13.0692
NON/ShiLtJ both 35.869 8.195 52.0093 19.7288
NZW/LacJ both 35.1905 9.3437 53.5932 16.7877
P/J both 108.5 14.5446 137.1462 79.8538
PL/J both 55.8833 10.1697 75.9129 35.8538
PWD/PhJ both 87.9554 8.6921 105.0747 70.836
RIIIS/J both 33.6548 9.3437 52.0575 15.252
SJL/J both 54.0238 11.5894 76.8496 31.198
SM/J both 37.8393 10.5266 58.5719 17.1067
SWR/J both 77.6786 13.4657 104.1998 51.1574
WSB/EiJ both 93.9167 9.0702 111.7807 76.0526




  GWAS USING LINEAR MIXED MODELS