Project measure / variable:   Yuan3   ALT_M12

ID, description, units MPD:24402   ALT_M12   alanine transaminase (plasma ALT)   [IU/L]  at age 12mo  
Data set, strains Yuan3   inbred   31 strains     sex: both     age: 52wks
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  STRAIN COMPARISON PLOT
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Yuan3 - alanine transaminase (plasma ALT) at age 12mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested28 strains30 strains
Mean of the strain means52.7   IU/L 51.7   IU/L
Median of the strain means49.0   IU/L 47.2   IU/L
SD of the strain means± 18.2 ± 19.6
Coefficient of variation (CV)0.344 0.379
Min–max range of strain means25.6   –   93.0   IU/L 31.0   –   109   IU/L
Mean sample size per strain6.3   mice 5.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2568.0579 2568.0579 4.3256 0.0385
strain 22 70535.9702 3206.1805 5.4004 < 0.0001
sex:strain 22 20225.3604 919.3346 1.5485 0.0589
Residuals 257 152579.5092 593.6946


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 28.8 5.8   8 2.05 0.202 21.0, 36.0 -1.32
129S1/SvImJ m 31.2 3.69   8 1.31 0.118 27.0, 36.0 -1.05
A/J f 72.7 12.4   6 5.05 0.17 59.0, 87.0 1.1
A/J m 53.1 7.7   8 2.72 0.145 45.0, 65.0 0.07
AKR/J m 43.3 16.4   3 9.49 0.379 31.0, 62.0 -0.43
BALB/cByJ m 46.4 10.4   8 3.67 0.224 32.0, 59.0 -0.27
BTBR T+ Itpr3tf/J f 35.9 5.08   8 1.8 0.142 31.0, 47.0 -0.93
BTBR T+ Itpr3tf/J m 40.7 7.95   7 3.01 0.195 33.0, 56.0 -0.56
BUB/BnJ f 49.5 8.89   6 3.63 0.18 35.0, 57.0 -0.18
BUB/BnJ m 52.9 14.9   7 5.63 0.282 39.0, 83.0 0.06
C3H/HeJ f 49.0 0.0   1   0.0 0.0 49.0, 49.0 -0.21
C3H/HeJ m 36.7 7.16   7 2.71 0.195 28.0, 46.0 -0.77
C57BL/10J f 79.9 45.1   7 17.0 0.565 55.0, 181.0 1.5
C57BL/10J m 59.6 8.28   7 3.13 0.139 49.0, 73.0 0.4
C57BL/6J f 43.4 3.36   5 1.5 0.0775 39.0, 48.0 -0.51
C57BL/6J m 34.8 9.19   8 3.25 0.265 29.0, 57.0 -0.86
C57BLKS/J f 49.0 19.1   8 6.75 0.39 30.0, 91.0 -0.21
C57BLKS/J m 41.3 2.73   6 1.12 0.0661 37.0, 45.0 -0.53
C57BR/cdJ f 93.0 46.1   6 18.8 0.495 45.0, 176.0 2.22
C57BR/cdJ m 76.3 4.73   3 2.73 0.0619 71.0, 80.0 1.26
C57L/J f 55.8 12.9   6 5.26 0.231 43.0, 76.0 0.17
C57L/J m 59.0 18.5   3 10.7 0.314 40.0, 77.0 0.37
CAST/EiJ f 59.3 18.8   6 7.66 0.316 47.0, 97.0 0.36
CBA/J f 25.6 2.7   5 1.21 0.106 23.0, 29.0 -1.49
CBA/J m 31.0 8.45   8 2.99 0.273 21.0, 44.0 -1.06
DBA/2J f 31.7 5.13   6 2.09 0.162 24.0, 37.0 -1.16
DBA/2J m 32.7 3.3   7 1.25 0.101 28.0, 38.0 -0.97
FVB/NJ f 73.5 18.8   8 6.63 0.255 53.0, 105.0 1.14
FVB/NJ m 44.2 5.89   5 2.63 0.133 37.0, 50.0 -0.38
KK/HlJ f 54.3 16.0   11 4.81 0.294 30.0, 86.0 0.09
KK/HlJ m 54.1 12.6   7 4.76 0.233 34.0, 73.0 0.12
LP/J f 81.7 95.7   7 36.2 1.17 31.0, 295.0 1.59
LP/J m 62.6 54.6   8 19.3 0.872 33.0, 194.0 0.56
MRL/MpJ f 58.4 9.64   7 3.64 0.165 41.0, 70.0 0.31
MRL/MpJ m 73.8 22.2   5 9.92 0.3 55.0, 112.0 1.13
NOD.B10Sn-H2b/J f 42.3 21.3   7 8.04 0.503 27.0, 87.0 -0.57
NOD.B10Sn-H2b/J m 31.9 5.64   8 1.99 0.177 27.0, 43.0 -1.01
NON/ShiLtJ f 36.9 3.34   7 1.26 0.0906 32.0, 41.0 -0.87
NON/ShiLtJ m 49.0 0.0   1   0.0 0.0 49.0, 49.0 -0.14
NZO/HlLtJ f 45.4 5.26   7 1.99 0.116 39.0, 53.0 -0.4
NZO/HlLtJ m 60.6 24.9   5 11.2 0.411 34.0, 94.0 0.45
NZW/LacJ f 39.2 13.5   8 4.78 0.344 25.0, 69.0 -0.75
NZW/LacJ m 35.6 5.66   8 2.0 0.159 27.0, 44.0 -0.82
P/J f 44.3 16.4   6 6.71 0.371 32.0, 77.0 -0.46
P/J m 39.2 12.7   4 6.34 0.323 31.0, 58.0 -0.64
PL/J f 80.5 29.9   6 12.2 0.371 57.0, 131.0 1.53
PL/J m 48.0 6.87   6 2.8 0.143 39.0, 55.0 -0.19
PWD/PhJ f 65.0 12.9   6 5.25 0.198 55.0, 88.0 0.68
PWD/PhJ m 109.0 61.2   4 30.6 0.562 69.0, 199.0 2.92
RIIIS/J f 34.6 4.39   5 1.96 0.127 30.0, 41.0 -1.0
RIIIS/J m 34.0 0.0   1   0.0 0.0 34.0, 34.0 -0.9
SJL/J f 67.8 28.2   5 12.6 0.415 49.0, 117.0 0.83
SJL/J m 44.0 6.69   9 2.23 0.152 37.0, 57.0 -0.39
SM/J f 31.1 10.1   7 3.81 0.324 20.0, 51.0 -1.19
SM/J m 55.3 33.9   6 13.8 0.613 23.0, 100.0 0.18
SWR/J f 48.0 0.0   1   0.0 0.0 48.0, 48.0 -0.26
SWR/J m 64.7 35.9   3 20.7 0.555 41.0, 106.0 0.66
WSB/EiJ m 106.0 14.7   5 6.57 0.138 90.0, 129.0 2.77


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 28.75 8.6146 45.7142 11.7858
129S1/SvImJ m 31.25 8.6146 48.2142 14.2858
A/J f 72.6667 9.9473 92.2553 53.078
A/J m 53.125 8.6146 70.0892 36.1608
BTBR T+ Itpr3tf/J f 35.875 8.6146 52.8392 18.9108
BTBR T+ Itpr3tf/J m 40.7143 9.2094 58.8498 22.5787
BUB/BnJ f 49.5 9.9473 69.0886 29.9114
BUB/BnJ m 52.8571 9.2094 70.9927 34.7216
C57BL/10J f 79.8571 9.2094 97.9927 61.7216
C57BL/10J m 59.5714 9.2094 77.707 41.4359
C57BL/6J f 43.4 10.8967 64.8583 21.9417
C57BL/6J m 34.75 8.6146 51.7142 17.7858
C57BLKS/J f 49.0 8.6146 65.9642 32.0358
C57BLKS/J m 41.3333 9.9473 60.922 21.7447
C57BR/cdJ f 93.0 9.9473 112.5886 73.4114
C57BR/cdJ m 76.3333 14.0676 104.0358 48.6308
C57L/J f 55.8333 9.9473 75.422 36.2447
C57L/J m 59.0 14.0676 86.7025 31.2975
CBA/J f 25.6 10.8967 47.0583 4.1417
CBA/J m 31.0 8.6146 47.9642 14.0358
DBA/2J f 31.6667 9.9473 51.2553 12.078
DBA/2J m 32.7143 9.2094 50.8498 14.5787
FVB/NJ f 73.5 8.6146 90.4642 56.5358
FVB/NJ m 44.2 10.8967 65.6583 22.7417
KK/HlJ f 54.2727 7.3466 68.7399 39.8056
KK/HlJ m 54.1429 9.2094 72.2784 36.0073
LP/J f 81.7143 9.2094 99.8498 63.5787
LP/J m 62.625 8.6146 79.5892 45.6608
MRL/MpJ f 58.4286 9.2094 76.5641 40.293
MRL/MpJ m 73.8 10.8967 95.2583 52.3417
NOD.B10Sn-H2b/J f 42.2857 9.2094 60.4213 24.1502
NOD.B10Sn-H2b/J m 31.875 8.6146 48.8392 14.9108
NZO/HlLtJ f 45.4286 9.2094 63.5641 27.293
NZO/HlLtJ m 60.6 10.8967 82.0583 39.1417
NZW/LacJ f 39.25 8.6146 56.2142 22.2858
NZW/LacJ m 35.625 8.6146 52.5892 18.6608
P/J f 44.3333 9.9473 63.922 24.7447
P/J m 39.25 12.1829 63.2411 15.2589
PL/J f 80.5 9.9473 100.0886 60.9114
PL/J m 48.0 9.9473 67.5886 28.4114
PWD/PhJ f 65.0 9.9473 84.5886 45.4114
PWD/PhJ m 108.75 12.1829 132.7411 84.7589
SJL/J f 67.8 10.8967 89.2583 46.3417
SJL/J m 44.0 8.1219 59.994 28.006
SM/J f 31.1429 9.2094 49.2784 13.0073
SM/J m 55.3333 9.9473 74.922 35.7447


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 30.0 6.0915 41.9955 18.0045
A/J both 62.8958 6.5795 75.8525 49.9392
BTBR T+ Itpr3tf/J both 38.2946 6.3053 50.7112 25.8781
BUB/BnJ both 51.1786 6.778 64.526 37.8312
C57BL/10J both 69.7143 6.512 82.5381 56.8905
C57BL/6J both 39.075 6.9453 52.752 25.398
C57BLKS/J both 45.1667 6.5795 58.1233 32.21
C57BR/cdJ both 84.6667 8.6146 101.6309 67.7024
C57L/J both 57.4167 8.6146 74.3809 40.4524
CBA/J both 28.3 6.9453 41.977 14.623
DBA/2J both 32.1905 6.778 45.5379 18.8431
FVB/NJ both 58.85 6.9453 72.527 45.173
KK/HlJ both 54.2078 5.8904 65.8073 42.6083
LP/J both 72.1696 6.3053 84.5862 59.7531
MRL/MpJ both 66.1143 7.1336 80.162 52.0666
NOD.B10Sn-H2b/J both 37.0804 6.3053 49.4969 24.6638
NZO/HlLtJ both 53.0143 7.1336 67.062 38.9666
NZW/LacJ both 37.4375 6.0915 49.433 25.442
P/J both 41.7917 7.864 57.2778 26.3055
PL/J both 64.25 7.0338 78.1013 50.3987
PWD/PhJ both 86.875 7.864 102.3612 71.3888
SJL/J both 55.9 6.7953 69.2816 42.5184
SM/J both 43.2381 6.778 56.5855 29.8907




  GWAS USING LINEAR MIXED MODELS