Project measure / variable:   Yuan3   ALT_M06

ID, description, units MPD:24401   ALT_M06   alanine transaminase (plasma ALT)   [IU/L]  at age 6mo  
Data set, strains Yuan3   inbred   31 strains     sex: both     age: 26wks
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  STRAIN COMPARISON PLOT
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Yuan3 - alanine transaminase (plasma ALT) at age 6mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains27 strains
Mean of the strain means51.9   IU/L 50.9   IU/L
Median of the strain means47.0   IU/L 46.2   IU/L
SD of the strain means± 20.3 ± 19.0
Coefficient of variation (CV)0.391 0.374
Min–max range of strain means28.4   –   114   IU/L 29.3   –   118   IU/L
Mean sample size per strain6.8   mice 7.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 550.5138 550.5138 2.1541 0.1432
strain 22 59145.5728 2688.4351 10.5194 < 0.0001
sex:strain 22 21019.6535 955.4388 3.7385 < 0.0001
Residuals 297 75903.7643 255.5682


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 29.1 6.33   8 2.24 0.217 21.0, 43.0 -1.12
129S1/SvImJ m 38.5 7.31   8 2.58 0.19 28.0, 51.0 -0.65
A/J f 94.6 35.6   7 13.4 0.376 57.0, 145.0 2.11
A/J m 56.0 13.8   6 5.63 0.246 37.0, 78.0 0.27
AKR/J f 78.0 53.6   8 19.0 0.687 39.0, 189.0 1.29
BALB/cByJ f 44.8 14.8   8 5.24 0.331 32.0, 69.0 -0.35
BALB/cByJ m 57.1 20.1   8 7.11 0.352 33.0, 98.0 0.32
BTBR T+ Itpr3tf/J f 36.2 8.58   8 3.03 0.237 29.0, 55.0 -0.77
BTBR T+ Itpr3tf/J m 38.0 5.35   8 1.89 0.141 32.0, 49.0 -0.68
BUB/BnJ f 64.8 15.4   8 5.43 0.237 46.0, 90.0 0.64
BUB/BnJ m 46.2 7.25   8 2.56 0.157 34.0, 54.0 -0.25
C3H/HeJ f 28.4 2.26   8 0.8 0.0798 26.0, 33.0 -1.16
C3H/HeJ m 38.2 10.2   16 2.55 0.267 30.0, 73.0 -0.67
C57BL/10J f 57.2 14.4   6 5.89 0.252 35.0, 77.0 0.26
C57BL/10J m 93.4 55.7   8 19.7 0.597 54.0, 229.0 2.23
C57BL/6J f 31.0 3.16   4 1.58 0.102 27.0, 34.0 -1.03
C57BL/6J m 37.0 0.0   1   0.0 0.0 37.0, 37.0 -0.73
C57BLKS/J f 46.9 6.73   8 2.38 0.144 36.0, 54.0 -0.24
C57BLKS/J m 52.0 16.4   7 6.18 0.315 36.0, 77.0 0.06
C57BR/cdJ f 57.9 22.1   8 7.82 0.382 11.0, 80.0 0.3
C57BR/cdJ m 67.5 11.6   8 4.11 0.172 50.0, 83.0 0.87
CAST/EiJ f 114.0 74.1   4 37.0 0.651 51.0, 198.0 3.06
CBA/J m 34.0 5.98   8 2.11 0.176 23.0, 41.0 -0.89
DBA/2J f 41.7 9.69   7 3.66 0.232 32.0, 61.0 -0.5
DBA/2J m 53.3 29.8   7 11.2 0.558 32.0, 110.0 0.13
FVB/NJ f 67.2 9.91   8 3.5 0.147 51.0, 78.0 0.76
FVB/NJ m 45.7 6.7   7 2.53 0.147 39.0, 57.0 -0.27
KK/HlJ f 50.9 19.2   8 6.79 0.377 38.0, 89.0 -0.05
LP/J f 34.8 4.38   5 1.96 0.126 29.0, 41.0 -0.84
LP/J m 35.0 0.0   3 0.0 0.0 35.0, 35.0 -0.84
MOLF/EiJ f 47.0 0.0   2   0.0 0.0 47.0, 47.0 -0.24
MOLF/EiJ m 32.0 0.0   1   0.0 0.0 32.0, 32.0 -0.99
MRL/MpJ m 60.9 26.2   8 9.27 0.431 41.0, 112.0 0.52
NOD.B10Sn-H2b/J f 40.0 9.09   4 4.55 0.227 30.0, 52.0 -0.58
NOD.B10Sn-H2b/J m 29.3 3.21   3 1.86 0.11 27.0, 33.0 -1.14
NON/ShiLtJ f 39.6 8.66   7 3.27 0.219 28.0, 52.0 -0.6
NON/ShiLtJ m 46.0 13.3   8 4.69 0.288 27.0, 64.0 -0.26
NZO/HlLtJ f 50.9 5.62   8 1.99 0.11 44.0, 59.0 -0.05
NZO/HlLtJ m 49.2 12.5   8 4.43 0.254 38.0, 78.0 -0.09
NZW/LacJ f 39.8 5.2   8 1.84 0.131 32.0, 49.0 -0.59
NZW/LacJ m 43.6 14.2   7 5.36 0.325 29.0, 70.0 -0.38
P/J f 31.5 4.04   6 1.65 0.128 24.0, 36.0 -1.0
PL/J f 75.1 6.31   7 2.38 0.084 67.0, 87.0 1.14
PL/J m 55.1 12.6   14 3.36 0.228 37.0, 89.0 0.22
PWD/PhJ f 49.0 5.29   7 2.0 0.108 43.0, 59.0 -0.14
PWD/PhJ m 62.4 5.32   7 2.01 0.0852 55.0, 68.0 0.6
RIIIS/J f 43.5 19.5   6 7.97 0.449 28.0, 81.0 -0.41
RIIIS/J m 34.0 8.7   8 3.08 0.256 26.0, 50.0 -0.89
SJL/J f 47.9 7.49   8 2.65 0.156 40.0, 63.0 -0.2
SJL/J m 45.5 7.48   6 3.05 0.164 38.0, 55.0 -0.28
SM/J f 33.5 12.8   16 3.21 0.383 22.0, 75.0 -0.9
SM/J m 50.0 19.7   8 6.95 0.393 34.0, 86.0 -0.05
SWR/J f 51.9 8.81   8 3.11 0.17 40.0, 63.0 0.0
SWR/J m 56.9 22.2   8 7.87 0.391 36.0, 108.0 0.31
WSB/EiJ f 77.0 24.0   2   17.0 0.312 60.0, 94.0 1.24
WSB/EiJ m 118.0 43.1   2   30.5 0.364 88.0, 149.0 3.52


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 29.125 5.6521 40.2482 18.0018
129S1/SvImJ m 38.5 5.6521 49.6232 27.3768
A/J f 94.5714 6.0423 106.4626 82.6802
A/J m 56.0 6.5265 68.844 43.156
BALB/cByJ f 44.75 5.6521 55.8732 33.6268
BALB/cByJ m 57.125 5.6521 68.2482 46.0018
BTBR T+ Itpr3tf/J f 36.25 5.6521 47.3732 25.1268
BTBR T+ Itpr3tf/J m 38.0 5.6521 49.1232 26.8768
BUB/BnJ f 64.75 5.6521 75.8732 53.6268
BUB/BnJ m 46.25 5.6521 57.3732 35.1268
C3H/HeJ f 28.375 5.6521 39.4982 17.2518
C3H/HeJ m 38.25 3.9966 46.1153 30.3847
C57BL/10J f 57.1667 6.5265 70.0106 44.3227
C57BL/10J m 93.375 5.6521 104.4982 82.2518
C57BLKS/J f 46.875 5.6521 57.9982 35.7518
C57BLKS/J m 52.0 6.0423 63.8912 40.1088
C57BR/cdJ f 57.875 5.6521 68.9982 46.7518
C57BR/cdJ m 67.5 5.6521 78.6232 56.3768
DBA/2J f 41.7143 6.0423 53.6055 29.8231
DBA/2J m 53.2857 6.0423 65.1769 41.3945
FVB/NJ f 67.25 5.6521 78.3732 56.1268
FVB/NJ m 45.7143 6.0423 57.6055 33.8231
LP/J f 34.8 7.1494 48.8699 20.7301
LP/J m 35.0 9.2298 53.1641 16.8359
NOD.B10Sn-H2b/J f 40.0 7.9933 55.7306 24.2694
NOD.B10Sn-H2b/J m 29.3333 9.2298 47.4974 11.1692
NON/ShiLtJ f 39.5714 6.0423 51.4626 27.6802
NON/ShiLtJ m 46.0 5.6521 57.1232 34.8768
NZO/HlLtJ f 50.875 5.6521 61.9982 39.7518
NZO/HlLtJ m 49.25 5.6521 60.3732 38.1268
NZW/LacJ f 39.75 5.6521 50.8732 28.6268
NZW/LacJ m 43.5714 6.0423 55.4626 31.6802
PL/J f 75.1429 6.0423 87.0341 63.2517
PL/J m 55.1429 4.2726 63.5512 46.7345
PWD/PhJ f 49.0 6.0423 60.8912 37.1088
PWD/PhJ m 62.4286 6.0423 74.3198 50.5374
RIIIS/J f 43.5 6.5265 56.344 30.656
RIIIS/J m 34.0 5.6521 45.1232 22.8768
SJL/J f 47.875 5.6521 58.9982 36.7518
SJL/J m 45.5 6.5265 58.344 32.656
SM/J f 33.5 3.9966 41.3653 25.6347
SM/J m 50.0 5.6521 61.1232 38.8768
SWR/J f 51.875 5.6521 62.9982 40.7518
SWR/J m 56.875 5.6521 67.9982 45.7518
WSB/EiJ f 77.0 11.3042 99.2464 54.7536
WSB/EiJ m 118.5 11.3042 140.7464 96.2536


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 33.8125 3.9966 41.6778 25.9472
A/J both 75.2857 4.447 84.0374 66.534
BALB/cByJ both 50.9375 3.9966 58.8028 43.0722
BTBR T+ Itpr3tf/J both 37.125 3.9966 44.9903 29.2597
BUB/BnJ both 55.5 3.9966 63.3653 47.6347
C3H/HeJ both 33.3125 3.4612 40.124 26.501
C57BL/10J both 75.2708 4.3168 83.7663 66.7753
C57BLKS/J both 49.4375 4.1369 57.5789 41.2961
C57BR/cdJ both 62.6875 3.9966 70.5528 54.8222
DBA/2J both 47.5 4.2726 55.9084 39.0916
FVB/NJ both 56.4821 4.1369 64.6235 48.3408
LP/J both 34.9 5.8374 46.388 23.412
NOD.B10Sn-H2b/J both 34.6667 6.1049 46.6811 22.6522
NON/ShiLtJ both 42.7857 4.1369 50.9271 34.6444
NZO/HlLtJ both 50.0625 3.9966 57.9278 42.1972
NZW/LacJ both 41.6607 4.1369 49.8021 33.5194
PL/J both 65.1429 3.7002 72.4247 57.861
PWD/PhJ both 55.7143 4.2726 64.1226 47.3059
RIIIS/J both 38.75 4.3168 47.2455 30.2545
SJL/J both 46.6875 4.3168 55.183 38.192
SM/J both 41.75 3.4612 48.5615 34.9385
SWR/J both 54.375 3.9966 62.2403 46.5097
WSB/EiJ both 97.75 7.9933 113.4806 82.0194




  GWAS USING LINEAR MIXED MODELS