Project measure / variable:   Petkova1   CD4_mem_central_M18

ID, description, units MPD:24239   CD4_mem_central_M18   CD4 T cells, central memory, as percentage of total CD4 T cells   [%]  at age 18mo  
Data set, strains Petkova1   inbred   30 strains     sex: both     age: 78wks
Procedure immune cell quantification
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Petkova1 - CD4 T cells, central memory, as percentage of total CD4 T cells at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains25 strains
Mean of the strain means7.28   % 5.73   %
Median of the strain means6.75   % 5.83   %
SD of the strain means± 2.94 ± 2.07
Coefficient of variation (CV)0.403 0.360
Min–max range of strain means0.0377   –   14.1   % 0.0361   –   9.18   %
Mean sample size per strain7.3   mice 6.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 288.473 288.473 40.537 < 0.0001
strain 22 1864.448 84.7476 11.909 < 0.0001
sex:strain 22 587.8853 26.7221 3.7551 < 0.0001
Residuals 278 1978.3272 7.1163


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 9.35 1.24   7 0.469 0.133 8.04, 11.9 0.7
129S1/SvImJ m 6.03 1.63   8 0.575 0.27 4.17, 8.69 0.14
A/J f 6.09 1.75   8 0.62 0.288 2.9, 8.3 -0.41
BALB/cByJ f 6.68 1.55   8 0.55 0.233 3.57, 8.48 -0.21
BALB/cByJ m 3.36 1.65   6 0.674 0.491 1.77, 6.56 -1.15
BTBR T+ Itpr3tf/J f 10.2 3.06   8 1.08 0.301 8.12, 17.3 0.99
BTBR T+ Itpr3tf/J m 8.94 1.65   5 0.738 0.185 6.7, 11.3 1.55
BUB/BnJ f 11.7 4.47   8 1.58 0.382 7.5, 20.6 1.5
BUB/BnJ m 6.96 1.23   6 0.502 0.177 5.69, 8.9 0.59
C3H/HeJ f 7.99 1.73   8 0.611 0.216 5.48, 11.2 0.24
C3H/HeJ m 5.83 1.8   8 0.638 0.309 3.28, 9.09 0.05
C57BL/10J f 7.18 1.89   7 0.715 0.263 4.55, 9.67 -0.04
C57BL/10J m 7.66 0.0   1   0.0 0.0 7.66, 7.66 0.93
C57BL/6J f 8.95 2.82   8 0.998 0.315 3.45, 13.8 0.57
C57BL/6J m 7.44 3.18   7 1.2 0.427 5.33, 14.3 0.83
C57BLKS/J f 5.77 2.65   7 1.0 0.459 2.73, 10.4 -0.52
C57BR/cdJ f 4.76 1.99   8 0.704 0.418 2.27, 8.95 -0.86
C57BR/cdJ m 3.89 1.46   8 0.517 0.375 1.72, 5.95 -0.89
C57L/J f 6.75 1.77   8 0.624 0.262 3.93, 8.69 -0.18
C57L/J m 5.29 2.19   6 0.894 0.414 2.92, 9.17 -0.21
CBA/J f 10.4 4.44   8 1.57 0.428 5.32, 19.9 1.06
CBA/J m 5.27 2.31   6 0.944 0.439 3.94, 9.93 -0.22
DBA/2J f 6.78 1.43   7 0.542 0.211 4.27, 8.25 -0.17
DBA/2J m 8.72 1.26   8 0.446 0.145 6.1, 9.94 1.45
FVB/NJ f 4.64 1.64   8 0.579 0.353 1.17, 6.57 -0.9
KK/HlJ f 4.92 2.99   7 1.13 0.609 0.988, 9.34 -0.8
KK/HlJ m 5.21 0.895   7 0.338 0.172 4.09, 6.84 -0.25
LP/J f 9.81 5.03   7 1.9 0.513 2.8, 18.4 0.86
LP/J m 9.18 4.16   8 1.47 0.453 4.25, 16.1 1.67
MOLF/EiJ f 0.0377 0.0226   9 0.00753 0.6 0.014, 0.068 -2.47
MOLF/EiJ m 0.0361 0.0364   7 0.0137 1.01 -2.76
MRL/MpJ f 9.76 3.56   6 1.45 0.365 4.94, 14.9 0.84
MRL/MpJ m 3.44 3.13   8 1.11 0.91 1.29, 10.1 -1.11
NOD.B10Sn-H2b/J f 4.34 1.03   7 0.391 0.238 2.46, 5.53 -1.0
NOD.B10Sn-H2b/J m 5.28 1.68   6 0.685 0.318 3.23, 7.5 -0.22
NON/ShiLtJ f 13.2 1.86   7 0.702 0.141 11.2, 16.4 2.01
NON/ShiLtJ m 6.38 3.63   7 1.37 0.569 0.76, 12.9 0.31
NZO/HlLtJ f 5.87 1.22   3 0.703 0.207 5.06, 7.27 -0.48
NZW/LacJ f 5.47 4.07   8 1.44 0.744 0.32, 12.7 -0.62
NZW/LacJ m 4.58 1.09   7 0.41 0.237 3.37, 6.05 -0.56
P/J f 5.75 1.89   5 0.845 0.329 3.78, 8.7 -0.52
P/J m 7.22 2.76   4 1.38 0.383 5.41, 11.3 0.72
PL/J f 7.15 2.68   4 1.34 0.375 3.4, 9.75 -0.05
PL/J m 2.59 0.853   5 0.382 0.33 1.55, 3.51 -1.52
PWD/PhJ f 4.88 2.71   8 0.96 0.556 0.24, 8.61 -0.82
PWD/PhJ m 6.11 1.45   8 0.513 0.237 4.23, 8.31 0.18
RIIIS/J m 5.33 2.65   8 0.937 0.497 3.08, 11.4 -0.19
SJL/J f 14.1 3.76   8 1.33 0.267 8.48, 18.4 2.32
SJL/J m 6.57 4.5   7 1.7 0.685 1.11, 13.4 0.41
SM/J f 7.05 1.31   7 0.494 0.185 5.25, 9.0 -0.08
SWR/J f 5.76 4.62   7 1.75 0.802 -0.52
SWR/J m 5.48 2.39   6 0.977 0.437 1.23, 8.39 -0.12
WSB/EiJ f 5.91 1.65   8 0.583 0.279 2.69, 8.08 -0.47
WSB/EiJ m 6.49 2.16   7 0.817 0.333 3.42, 10.4 0.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 9.3457 1.0083 11.3305 7.3609
129S1/SvImJ m 6.03 0.9432 7.8866 4.1734
BALB/cByJ f 6.6813 0.9432 8.5379 4.8246
BALB/cByJ m 3.36 1.0891 5.5038 1.2162
BTBR T+ Itpr3tf/J f 10.1813 0.9432 12.0379 8.3246
BTBR T+ Itpr3tf/J m 8.936 1.193 11.2845 6.5875
BUB/BnJ f 11.7125 0.9432 13.5691 9.8559
BUB/BnJ m 6.9567 1.0891 9.1005 4.8128
C3H/HeJ f 7.9887 0.9432 9.8454 6.1321
C3H/HeJ m 5.8275 0.9432 7.6841 3.9709
C57BL/6J f 8.9537 0.9432 10.8104 7.0971
C57BL/6J m 7.4443 1.0083 9.4291 5.4595
C57BR/cdJ f 4.7637 0.9432 6.6204 2.9071
C57BR/cdJ m 3.8912 0.9432 5.7479 2.0346
C57L/J f 6.75 0.9432 8.6066 4.8934
C57L/J m 5.2883 1.0891 7.4322 3.1445
CBA/J f 10.3775 0.9432 12.2341 8.5209
CBA/J m 5.2717 1.0891 7.4155 3.1278
DBA/2J f 6.7829 1.0083 8.7677 4.798
DBA/2J m 8.72 0.9432 10.5766 6.8634
KK/HlJ f 4.9154 1.0083 6.9002 2.9306
KK/HlJ m 5.2057 1.0083 7.1905 3.2209
LP/J f 9.8129 1.0083 11.7977 7.828
LP/J m 9.185 0.9432 11.0416 7.3284
MOLF/EiJ f 0.0377 0.8892 1.7881 0.0
MOLF/EiJ m 0.0361 1.0083 2.021 0.0
MRL/MpJ f 9.76 1.0891 11.9038 7.6162
MRL/MpJ m 3.4362 0.9432 5.2929 1.5796
NOD.B10Sn-H2b/J f 4.3414 1.0083 6.3262 2.3566
NOD.B10Sn-H2b/J m 5.28 1.0891 7.4238 3.1362
NON/ShiLtJ f 13.2143 1.0083 15.1991 11.2295
NON/ShiLtJ m 6.3829 1.0083 8.3677 4.398
NZW/LacJ f 5.4663 0.9432 7.3229 3.6096
NZW/LacJ m 4.5814 1.0083 6.5662 2.5966
P/J f 5.752 1.193 8.1005 3.4035
P/J m 7.2225 1.3338 9.8482 4.5968
PL/J f 7.1525 1.3338 9.7782 4.5268
PL/J m 2.588 1.193 4.9365 0.2395
PWD/PhJ f 4.88 0.9432 6.7366 3.0234
PWD/PhJ m 6.105 0.9432 7.9616 4.2484
SJL/J f 14.0862 0.9432 15.9429 12.2296
SJL/J m 6.5729 1.0083 8.5577 4.588
SWR/J f 5.7614 1.0083 7.7462 3.7766
SWR/J m 5.48 1.0891 7.6238 3.3362
WSB/EiJ f 5.9125 0.9432 7.7691 4.0559
WSB/EiJ m 6.4929 1.0083 8.4777 4.508


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 7.6879 0.6903 9.0468 6.3289
BALB/cByJ both 5.0206 0.7203 6.4386 3.6026
BTBR T+ Itpr3tf/J both 9.5586 0.7604 11.0555 8.0618
BUB/BnJ both 9.3346 0.7203 10.7526 7.9166
C3H/HeJ both 6.9081 0.6669 8.221 5.5953
C57BL/6J both 8.199 0.6903 9.5579 6.8401
C57BR/cdJ both 4.3275 0.6669 5.6403 3.0147
C57L/J both 6.0192 0.7203 7.4372 4.6011
CBA/J both 7.8246 0.7203 9.2426 6.4066
DBA/2J both 7.7514 0.6903 9.1103 6.3925
KK/HlJ both 5.0606 0.713 6.464 3.6571
LP/J both 9.4989 0.6903 10.8578 8.14
MOLF/EiJ both 0.0369 0.6722 1.3601 0.0
MRL/MpJ both 6.5981 0.7203 8.0161 5.1801
NOD.B10Sn-H2b/J both 4.8107 0.7421 6.2715 3.3499
NON/ShiLtJ both 9.7986 0.713 11.202 8.3951
NZW/LacJ both 5.0238 0.6903 6.3828 3.6649
P/J both 6.4872 0.8948 8.2486 4.7259
PL/J both 4.8702 0.8948 6.6316 3.1089
PWD/PhJ both 5.4925 0.6669 6.8053 4.1797
SJL/J both 10.3296 0.6903 11.6885 8.9706
SWR/J both 5.6207 0.7421 7.0815 4.1599
WSB/EiJ both 6.2027 0.6903 7.5616 4.8438




  GWAS USING LINEAR MIXED MODELS