Petkova1: Aging study: Peripheral blood leukocytes (PBL profiles) in 32 inbred strains of mice (2007)

Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics. 2008 Aug 15;34(3):304-14. Epub 2008 Jun 10.   PubMed 18544662     FullText


       
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Participants Stefka Petkova       The Jackson Laboratory Bar Harbor, ME
Derry Roopenian       The Jackson Laboratory Bar Harbor, ME
With: Schultz D, Godfrey D
ContactDerry Roopenian     derry.roopenian@jax.org     Lab web site
AffiliationJAX Nathan Shock Aging Center
AcknowledgementsFunding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersPetkova1     MPD:242
Data changelog 1 update/correction.       Initial release date: 06/2009.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of aging effects on immune system. Animals were evaluated using flow cytometry.

Summary of procedures that were conducted
• complete blood count Hematology. Aging study, 6mo, 12mo, 18mo, 24mo.
• immune cell quantification Aging study, 6mo, 12mo, 18mo, 24mo.
Mice: inbred   32 strains   ♀♂   age 6, 12, 18, 24 mo   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Petkova1 24201 immune cell quantification (none) white blood cell count (WBC)   [n/µL]     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 24206 immune cell quantification (none) lymphocyte differential   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24211 immune cell quantification (none) neutrophil differential   [%]     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 24216 immune cell quantification (none) eosinophil differential   [%]     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 24221 immune cell quantification (none) monocyte differential   [%]     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 24225 immune cell quantification (none) B cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 24229 immune cell quantification (none) CD4 T cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24233 immune cell quantification (none) CD4 T cells - naive cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24237 immune cell quantification (none) CD4 T cells - central memory cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24241 immune cell quantification (none) CD4 T cells - effector memory cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24246 immune cell quantification (none) CD4 T cells - effector cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24251 immune cell quantification (none) CD8 T cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24256 immune cell quantification (none) CD8 T cells - naive cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24261 immune cell quantification (none) CD8 T cells - central memory cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24266 immune cell quantification (none) CD8 T cells - effector memory cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24271 immune cell quantification (none) CD8 T cells - effector cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 24276 immune cell quantification (none) NK cells   [%]     6mo    12mo    18mo    24mo inbred 32 both N=8
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