MPD: Project measure / variable: Petkova1 B_cells

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Petkova1 - B cells, as percentage of total lymphocytes at age 12mo

Measure Summary	Female	Male
Number of strains tested	30 strains	30 strains
Mean of the strain means	37.9 %	42.6 %
Median of the strain means	31.9 %	41.4 %
SD of the strain means	± 17.7	± 18.0
Coefficient of variation (CV)	0.466	0.422
Min–max range of strain means	9.89 – 74.0 %	8.91 – 77.2 %
Mean sample size per strain	7.6 mice	7.7 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
sex	1	3969.5013	3969.5013	79.2386	< 0.0001
strain	28	118367.428	4227.4081	84.3869	< 0.0001
sex:strain	28	15242.2877	544.3674	10.8666	< 0.0001
Residuals	388	19437.0831	50.0956

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Min, Max	Z score
129S1/SvImJ	f	26.8	2.46	8	0.869	0.0917	22.8, 29.8	-0.63
129S1/SvImJ	m	65.5	5.36	8	1.89	0.0818	59.2, 75.4	1.27
A/J	f	27.9	9.96	8	3.52	0.357	15.3, 42.0	-0.57
A/J	m	36.9	9.35	8	3.31	0.254	23.0, 51.4	-0.32
AKR/J	m	39.1	20.5	5	9.15	0.523	3.02, 52.8	-0.19
BALB/cByJ	f	32.2	9.97	8	3.53	0.309	16.0, 44.2	-0.33
BALB/cByJ	m	50.5	10.1	8	3.57	0.2	37.8, 62.5	0.44
BTBR T⁺ Itpr3^tf/J	f	26.2	3.5	8	1.24	0.134	22.2, 32.8	-0.66
BTBR T⁺ Itpr3^tf/J	m	26.3	3.89	7	1.47	0.148	21.7, 32.1	-0.9
BUB/BnJ	f	48.5	7.38	6	3.01	0.152	39.3, 59.4	0.6
BUB/BnJ	m	62.4	5.62	9	1.87	0.0901	57.3, 70.1	1.1
C3H/HeJ	f	31.4	5.24	8	1.85	0.167	26.8, 42.5	-0.37
C3H/HeJ	m	44.8	6.53	8	2.31	0.146	37.7, 58.1	0.12
C57BL/10J	f	70.7	6.63	8	2.34	0.0937	62.6, 78.7	1.85
C57BL/10J	m	77.1	6.8	7	2.57	0.0882	65.1, 84.2	1.92
C57BL/6J	f	74.0	8.51	8	3.01	0.115	60.4, 84.1	2.04
C57BL/6J	m	77.2	5.0	8	1.77	0.0647	70.9, 86.0	1.92
C57BLKS/J	f	65.2	4.09	8	1.45	0.0627	56.5, 69.0	1.54
C57BLKS/J	m	57.3	3.94	8	1.39	0.0688	50.1, 61.6	0.82
C57BR/cdJ	f	47.6	5.93	8	2.1	0.125	40.2, 58.5	0.55
C57BR/cdJ	m	45.0	6.7	8	2.37	0.149	35.4, 55.7	0.13
C57L/J	f	57.7	4.09	7	1.55	0.0708	52.1, 62.2	1.12
C57L/J	m	66.6	5.11	8	1.81	0.0766	56.8, 72.5	1.34
CAST/EiJ	f	69.6	1.9	3	1.1	0.0273	67.7, 71.5	1.79
CBA/J	f	25.5	5.94	8	2.1	0.233	19.0, 35.8	-0.7
CBA/J	m	29.8	7.09	8	2.51	0.238	19.5, 41.4	-0.71
DBA/2J	f	55.2	7.84	6	3.2	0.142	43.8, 66.6	0.98
DBA/2J	m	45.1	7.94	7	3.0	0.176	36.8, 54.3	0.14
FVB/NJ	f	20.3	3.37	8	1.19	0.166	13.6, 24.8	-1.0
FVB/NJ	m	20.8	3.79	8	1.34	0.182	15.4, 27.6	-1.21
KK/HlJ	f	45.7	5.26	8	1.86	0.115	38.4, 55.6	0.44
KK/HlJ	m	33.5	6.31	8	2.23	0.189	22.6, 43.2	-0.5
LP/J	f	31.6	9.76	7	3.69	0.309	21.5, 51.2	-0.36
LP/J	m	15.6	5.78	8	2.04	0.37	8.47, 26.8	-1.5
MOLF/EiJ	f	47.8	7.73	7	2.92	0.162	35.0, 59.7	0.56
MOLF/EiJ	m	39.1	9.2	9	3.07	0.235	29.0, 51.7	-0.19
MRL/MpJ	f	19.4	7.73	8	2.73	0.398	10.4, 36.3	-1.05
MRL/MpJ	m	8.91	6.67	8	2.36	0.748	2.04, 22.1	-1.87
NON/ShiLtJ	f	44.1	17.3	8	6.13	0.394	14.1, 66.4	0.35
NON/ShiLtJ	m	58.2	7.97	6	3.25	0.137	50.5, 73.0	0.87
NZO/HlLtJ	f	26.3	4.72	6	1.93	0.18	21.8, 34.2	-0.66
NZO/HlLtJ	m	46.1	8.09	7	3.06	0.176	32.5, 55.1	0.2
NZW/LacJ	f	26.3	2.82	8	0.998	0.107	22.5, 31.5	-0.66
NZW/LacJ	m	33.1	6.43	8	2.27	0.194	24.7, 40.6	-0.53
P/J	f	50.8	14.8	8	5.24	0.292	31.4, 67.3	0.73
P/J	m	66.1	5.07	7	1.92	0.0768	59.5, 72.1	1.31
PL/J	f	9.89	4.0	7	1.51	0.404	6.84, 18.3	-1.59
PL/J	m	19.1	3.3	6	1.35	0.173	14.9, 24.1	-1.31
PWD/PhJ	f	27.9	3.27	8	1.16	0.117	20.5, 30.8	-0.57
PWD/PhJ	m	43.7	3.94	8	1.39	0.0903	38.4, 49.1	0.06
RIIIS/J	f	16.4	3.0	8	1.06	0.184	12.1, 20.2	-1.22
RIIIS/J	m	27.7	2.64	8	0.933	0.0952	22.6, 30.6	-0.83
SJL/J	f	21.3	11.1	8	3.92	0.521	7.64, 43.5	-0.94
SJL/J	m	37.0	8.96	9	2.99	0.242	25.0, 50.5	-0.31
SM/J	f	37.5	5.89	8	2.08	0.157	32.6, 48.5	-0.03
SM/J	m	49.1	7.34	8	2.59	0.149	41.5, 62.4	0.36
SWR/J	f	39.2	6.77	7	2.56	0.173	29.3, 45.6	0.07
SWR/J	m	35.5	8.42	7	3.18	0.237	21.9, 46.3	-0.39
WSB/EiJ	f	15.5	3.32	8	1.17	0.213	11.6, 21.0	-1.27
WSB/EiJ	m	20.2	4.27	8	1.51	0.211	14.0, 27.0	-1.24

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	f	26.7875	2.5024	31.7074	21.8676
129S1/SvImJ	m	65.5375	2.5024	70.4574	60.6176
A/J	f	27.875	2.5024	32.7949	22.9551
A/J	m	36.8625	2.5024	41.7824	31.9426
BALB/cByJ	f	32.25	2.5024	37.1699	27.3301
BALB/cByJ	m	50.5375	2.5024	55.4574	45.6176
BTBR T⁺ Itpr3^tf/J	f	26.1875	2.5024	31.1074	21.2676
BTBR T⁺ Itpr3^tf/J	m	26.2714	2.6752	31.5311	21.0118
BUB/BnJ	f	48.4833	2.8895	54.1644	42.8023
BUB/BnJ	m	62.4	2.3593	67.0386	57.7614
C3H/HeJ	f	31.375	2.5024	36.2949	26.4551
C3H/HeJ	m	44.825	2.5024	49.7449	39.9051
C57BL/10J	f	70.7375	2.5024	75.6574	65.8176
C57BL/10J	m	77.1143	2.6752	82.3739	71.8547
C57BL/6J	f	74.05	2.5024	78.9699	69.1301
C57BL/6J	m	77.225	2.5024	82.1449	72.3051
C57BLKS/J	f	65.2375	2.5024	70.1574	60.3176
C57BLKS/J	m	57.25	2.5024	62.1699	52.3301
C57BR/cdJ	f	47.6	2.5024	52.5199	42.6801
C57BR/cdJ	m	45.025	2.5024	49.9449	40.1051
C57L/J	f	57.7429	2.6752	63.0025	52.4832
C57L/J	m	66.65	2.5024	71.5699	61.7301
CBA/J	f	25.4875	2.5024	30.4074	20.5676
CBA/J	m	29.7625	2.5024	34.6824	24.8426
DBA/2J	f	55.1833	2.8895	60.8644	49.5023
DBA/2J	m	45.0857	2.6752	50.3453	39.8261
FVB/NJ	f	20.3	2.5024	25.2199	15.3801
FVB/NJ	m	20.7875	2.5024	25.7074	15.8676
KK/HlJ	f	45.675	2.5024	50.5949	40.7551
KK/HlJ	m	33.4625	2.5024	38.3824	28.5426
LP/J	f	31.6143	2.6752	36.8739	26.3547
LP/J	m	15.6338	2.5024	20.5537	10.7138
MOLF/EiJ	f	47.7714	2.6752	53.0311	42.5118
MOLF/EiJ	m	39.0778	2.3593	43.7163	34.4392
MRL/MpJ	f	19.4	2.5024	24.3199	14.4801
MRL/MpJ	m	8.915	2.5024	13.8349	3.9951
NON/ShiLtJ	f	44.0625	2.5024	48.9824	39.1426
NON/ShiLtJ	m	58.25	2.8895	63.9311	52.5689
NZO/HlLtJ	f	26.2833	2.8895	31.9644	20.6023
NZO/HlLtJ	m	46.0714	2.6752	51.3311	40.8118
NZW/LacJ	f	26.2875	2.5024	31.2074	21.3676
NZW/LacJ	m	33.1125	2.5024	38.0324	28.1926
P/J	f	50.7875	2.5024	55.7074	45.8676
P/J	m	66.0571	2.6752	71.3168	60.7975
PL/J	f	9.8886	2.6752	15.1482	4.6289
PL/J	m	19.0667	2.8895	24.7477	13.3856
PWD/PhJ	f	27.8875	2.5024	32.8074	22.9676
PWD/PhJ	m	43.675	2.5024	48.5949	38.7551
RIIIS/J	f	16.35	2.5024	21.2699	11.4301
RIIIS/J	m	27.7125	2.5024	32.6324	22.7926
SJL/J	f	21.28	2.5024	26.1999	16.3601
SJL/J	m	37.0	2.3593	41.6386	32.3614
SM/J	f	37.4625	2.5024	42.3824	32.5426
SM/J	m	49.075	2.5024	53.9949	44.1551
SWR/J	f	39.1857	2.6752	44.4453	33.9261
SWR/J	m	35.5429	2.6752	40.8025	30.2832
WSB/EiJ	f	15.5375	2.5024	20.4574	10.6176
WSB/EiJ	m	20.2125	2.5024	25.1324	15.2926

LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	both	46.1625	1.7695	49.6414	42.6836
A/J	both	32.3687	1.7695	35.8477	28.8898
BALB/cByJ	both	41.3938	1.7695	44.8727	37.9148
BTBR T⁺ Itpr3^tf/J	both	26.2295	1.8316	29.8305	22.6284
BUB/BnJ	both	55.4417	1.8652	59.1088	51.7746
C3H/HeJ	both	38.1	1.7695	41.5789	34.6211
C57BL/10J	both	73.9259	1.8316	77.5269	70.3249
C57BL/6J	both	75.6375	1.7695	79.1164	72.1586
C57BLKS/J	both	61.2437	1.7695	64.7227	57.7648
C57BR/cdJ	both	46.3125	1.7695	49.7914	42.8336
C57L/J	both	62.1964	1.8316	65.7975	58.5954
CBA/J	both	27.625	1.7695	31.1039	24.1461
DBA/2J	both	50.1345	1.9689	54.0055	46.2635
FVB/NJ	both	20.5437	1.7695	24.0227	17.0648
KK/HlJ	both	39.5688	1.7695	43.0477	36.0898
LP/J	both	23.624	1.8316	27.225	20.023
MOLF/EiJ	both	43.4246	1.7834	46.931	39.9182
MRL/MpJ	both	14.1575	1.7695	17.6364	10.6786
NON/ShiLtJ	both	51.1562	1.9112	54.9139	47.3986
NZO/HlLtJ	both	36.1774	1.9689	40.0484	32.3064
NZW/LacJ	both	29.7	1.7695	33.1789	26.2211
P/J	both	58.4223	1.8316	62.0233	54.8213
PL/J	both	14.4776	1.9689	18.3486	10.6066
PWD/PhJ	both	35.7812	1.7695	39.2602	32.3023
RIIIS/J	both	22.0312	1.7695	25.5102	18.5523
SJL/J	both	29.14	1.7196	32.5209	25.7591
SM/J	both	43.2687	1.7695	46.7477	39.7898
SWR/J	both	37.3643	1.8916	41.0834	33.6452
WSB/EiJ	both	17.875	1.7695	21.3539	14.3961

INDIVIDUAL ANIMAL VALUES

Click here to view individual animal values

GWAS USING LINEAR MIXED MODELS

ID, description, units	MPD:24226 B_cells_M12 B cells, as percentage of total lymphocytes [%] at age 12mo
Data set, strains	Petkova1 inbred 31 strains sex: both age: 52wks
Procedure	immune cell quantification
Ontology mappings	MA:0000059 blood MP:0002458 abnormal B cell number VT:0002458 B cell quantity