Phenotype measure:   Lake2   withdrawal_reflex

ID, description, units MPD:21734   withdrawal_reflex   withdrawal reflex following toe pinch of hind foot mid-digit on horizontal wire-grid (score 0-4)   [score]
Data set, strains Lake2   B6.A consomic w/par   23 strains     sex: both     age: 8wks
Procedure observation (SHIRPA)
Ontology mappings

  STRAIN COMPARISON PLOT
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Lake2 - withdrawal reflex following toe pinch of hind foot mid-digit on horizontal wire-grid (score 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains23 strains
Mean of the strain means1.77   score 1.87   score
Median of the strain means1.75   score 1.88   score
SD of the strain means± 0.281 ± 0.415
Coefficient of variation (CV)0.159 0.222
Min–max range of strain means1.38   –   2.25   score 1.12   –   2.60   score
Mean sample size per strain8.3   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.6277 1.6277 4.8896 0.0277
strain 22 26.0121 1.1824 3.5519 < 0.0001
sex:strain 22 19.8573 0.9026 2.7115 0.0001
Residuals 335 111.5161 0.3329


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 1.44 0.512   16 0.128 0.356 1.0, 2.0 -1.17
A/J m 1.75 0.463   8 0.164 0.265 1.0, 2.0 -0.29
B6.A-Chr1 f 1.75 0.463   8 0.164 0.265 1.0, 2.0 -0.07
B6.A-Chr1 m 2.0 0.756   8 0.267 0.378 1.0, 3.0 0.31
B6.A-Chr10 f 1.62 0.744   8 0.263 0.458 1.0, 3.0 -0.53
B6.A-Chr10 m 2.12 0.354   8 0.125 0.166 2.0, 3.0 0.6
B6.A-Chr11 f 1.62 0.744   8 0.263 0.458 1.0, 3.0 -0.53
B6.A-Chr11 m 2.6 0.516   10 0.163 0.199 2.0, 3.0 1.76
B6.A-Chr12 f 2.25 0.463   8 0.164 0.206 2.0, 3.0 1.72
B6.A-Chr12 m 2.38 0.518   8 0.183 0.218 2.0, 3.0 1.23
B6.A-Chr13 f 2.0 0.0   5 0.0 0.0 2.0, 2.0 0.82
B6.A-Chr13 m 2.29 0.488   7 0.184 0.213 2.0, 3.0 1.01
B6.A-Chr14 f 2.0 0.0   8 0.0 0.0 2.0, 2.0 0.82
B6.A-Chr14 m 1.5 0.535   8 0.189 0.356 1.0, 2.0 -0.89
B6.A-Chr15 f 1.38 0.518   8 0.183 0.376 1.0, 2.0 -1.39
B6.A-Chr15 m 2.0 0.926   8 0.327 0.463 1.0, 3.0 0.31
B6.A-Chr16 f 2.25 0.463   8 0.164 0.206 2.0, 3.0 1.72
B6.A-Chr16 m 1.88 0.354   8 0.125 0.189 1.0, 2.0 0.02
B6.A-Chr17 f 2.0 0.0   8 0.0 0.0 2.0, 2.0 0.82
B6.A-Chr17 m 1.12 0.354   8 0.125 0.314 1.0, 2.0 -1.81
B6.A-Chr18 f 1.75 0.707   8 0.25 0.404 1.0, 3.0 -0.07
B6.A-Chr18 m 1.62 0.518   8 0.183 0.318 1.0, 2.0 -0.6
B6.A-Chr19 f 2.12 0.991   8 0.35 0.466 1.0, 3.0 1.25
B6.A-Chr19 m 2.0 0.0   8 0.0 0.0 2.0, 2.0 0.31
B6.A-Chr2 f 2.12 0.835   8 0.295 0.393 1.0, 3.0 1.25
B6.A-Chr2 m 1.88 0.641   8 0.227 0.342 1.0, 3.0 0.02
B6.A-Chr3 f 1.75 0.463   8 0.164 0.265 1.0, 2.0 -0.07
B6.A-Chr3 m 1.5 0.535   8 0.189 0.356 1.0, 2.0 -0.89
B6.A-Chr4 f 2.0 0.0   7 0.0 0.0 2.0, 2.0 0.82
B6.A-Chr4 m 2.12 0.835   8 0.295 0.393 1.0, 3.0 0.6
B6.A-Chr5 f 1.38 0.518   8 0.183 0.376 1.0, 2.0 -1.39
B6.A-Chr5 m 1.5 0.535   8 0.189 0.356 1.0, 2.0 -0.89
B6.A-Chr6 f 1.88 0.354   8 0.125 0.189 1.0, 2.0 0.4
B6.A-Chr6 m 2.5 0.535   8 0.189 0.214 2.0, 3.0 1.52
B6.A-Chr7 f 1.5 0.535   8 0.189 0.356 1.0, 2.0 -0.96
B6.A-Chr7 m 1.38 0.518   8 0.183 0.376 1.0, 2.0 -1.18
B6.A-Chr8 f 1.75 0.463   8 0.164 0.265 1.0, 2.0 -0.07
B6.A-Chr8 m 1.25 0.463   8 0.164 0.37 1.0, 2.0 -1.49
B6.A-Chr9 f 1.62 0.916   8 0.324 0.564 1.0, 3.0 -0.53
B6.A-Chr9 m 2.12 0.354   8 0.125 0.166 2.0, 3.0 0.6
B6.A-ChrX f 1.38 0.744   8 0.263 0.541 -1.39
B6.A-ChrX m 1.75 0.463   8 0.164 0.265 1.0, 2.0 -0.29
B6.A-ChrY f 1.5 0.926   8 0.327 0.617 1.0, 3.0 -0.96
B6.A-ChrY m 2.38 0.916   8 0.324 0.386 1.0, 3.0 1.23
C57BL/6J f 1.62 0.5   16 0.125 0.308 1.0, 2.0 -0.53
C57BL/6J m 1.38 0.518   8 0.183 0.376 1.0, 2.0 -1.18


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 1.4375 0.1442 1.7212 1.1538
A/J m 1.75 0.204 2.1513 1.3487
B6.A-Chr1 f 1.75 0.204 2.1513 1.3487
B6.A-Chr1 m 2.0 0.204 2.4013 1.5987
B6.A-Chr10 f 1.625 0.204 2.0263 1.2237
B6.A-Chr10 m 2.125 0.204 2.5263 1.7237
B6.A-Chr11 f 1.625 0.204 2.0263 1.2237
B6.A-Chr11 m 2.6 0.1825 2.9589 2.2411
B6.A-Chr12 f 2.25 0.204 2.6513 1.8487
B6.A-Chr12 m 2.375 0.204 2.7763 1.9737
B6.A-Chr13 f 2.0 0.258 2.5076 1.4924
B6.A-Chr13 m 2.2857 0.2181 2.7147 1.8568
B6.A-Chr14 f 2.0 0.204 2.4013 1.5987
B6.A-Chr14 m 1.5 0.204 1.9013 1.0987
B6.A-Chr15 f 1.375 0.204 1.7763 0.9737
B6.A-Chr15 m 2.0 0.204 2.4013 1.5987
B6.A-Chr16 f 2.25 0.204 2.6513 1.8487
B6.A-Chr16 m 1.875 0.204 2.2763 1.4737
B6.A-Chr17 f 2.0 0.204 2.4013 1.5987
B6.A-Chr17 m 1.125 0.204 1.5263 0.7237
B6.A-Chr18 f 1.75 0.204 2.1513 1.3487
B6.A-Chr18 m 1.625 0.204 2.0263 1.2237
B6.A-Chr19 f 2.125 0.204 2.5263 1.7237
B6.A-Chr19 m 2.0 0.204 2.4013 1.5987
B6.A-Chr2 f 2.125 0.204 2.5263 1.7237
B6.A-Chr2 m 1.875 0.204 2.2763 1.4737
B6.A-Chr3 f 1.75 0.204 2.1513 1.3487
B6.A-Chr3 m 1.5 0.204 1.9013 1.0987
B6.A-Chr4 f 2.0 0.2181 2.429 1.571
B6.A-Chr4 m 2.125 0.204 2.5263 1.7237
B6.A-Chr5 f 1.375 0.204 1.7763 0.9737
B6.A-Chr5 m 1.5 0.204 1.9013 1.0987
B6.A-Chr6 f 1.875 0.204 2.2763 1.4737
B6.A-Chr6 m 2.5 0.204 2.9013 2.0987
B6.A-Chr7 f 1.5 0.204 1.9013 1.0987
B6.A-Chr7 m 1.375 0.204 1.7763 0.9737
B6.A-Chr8 f 1.75 0.204 2.1513 1.3487
B6.A-Chr8 m 1.25 0.204 1.6513 0.8487
B6.A-Chr9 f 1.625 0.204 2.0263 1.2237
B6.A-Chr9 m 2.125 0.204 2.5263 1.7237
B6.A-ChrX f 1.375 0.204 1.7763 0.9737
B6.A-ChrX m 1.75 0.204 2.1513 1.3487
B6.A-ChrY f 1.5 0.204 1.9013 1.0987
B6.A-ChrY m 2.375 0.204 2.7763 1.9737
C57BL/6J f 1.625 0.1442 1.9087 1.3413
C57BL/6J m 1.375 0.204 1.7763 0.9737


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 1.5938 0.1249 1.8395 1.348
B6.A-Chr1 both 1.875 0.1442 2.1587 1.5913
B6.A-Chr10 both 1.875 0.1442 2.1587 1.5913
B6.A-Chr11 both 2.1125 0.1368 2.3817 1.8433
B6.A-Chr12 both 2.3125 0.1442 2.5962 2.0288
B6.A-Chr13 both 2.1429 0.1689 2.4751 1.8106
B6.A-Chr14 both 1.75 0.1442 2.0337 1.4663
B6.A-Chr15 both 1.6875 0.1442 1.9712 1.4038
B6.A-Chr16 both 2.0625 0.1442 2.3462 1.7788
B6.A-Chr17 both 1.5625 0.1442 1.8462 1.2788
B6.A-Chr18 both 1.6875 0.1442 1.9712 1.4038
B6.A-Chr19 both 2.0625 0.1442 2.3462 1.7788
B6.A-Chr2 both 2.0 0.1442 2.2837 1.7163
B6.A-Chr3 both 1.625 0.1442 1.9087 1.3413
B6.A-Chr4 both 2.0625 0.1493 2.3562 1.7688
B6.A-Chr5 both 1.4375 0.1442 1.7212 1.1538
B6.A-Chr6 both 2.1875 0.1442 2.4712 1.9038
B6.A-Chr7 both 1.4375 0.1442 1.7212 1.1538
B6.A-Chr8 both 1.5 0.1442 1.7837 1.2163
B6.A-Chr9 both 1.875 0.1442 2.1587 1.5913
B6.A-ChrX both 1.5625 0.1442 1.8462 1.2788
B6.A-ChrY both 1.9375 0.1442 2.2212 1.6538
C57BL/6J both 1.5 0.1249 1.7457 1.2543




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA