Project measure / variable:   Threadgill1   GSTpi_Rx300

ID, description, units MPD:19491   GSTpi_Rx300   glutathione transferase   [µg/mL]  post-Rx 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-12wks
Procedure metabolite quantification
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  STRAIN COMPARISON PLOT
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Threadgill1 - glutathione transferase post-Rx 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means751   µg/mL
Median of the strain means749   µg/mL
SD of the strain means± 265
Coefficient of variation (CV)0.353
Min–max range of strain means231   –   1529   µg/mL
Mean sample size per strain3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 8344583.3804 238416.668 2.9088 < 0.0001
Residuals 98 8032392.4405 81963.1882


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 993.0 318.0   3 184.0 0.321 660.0, 1294.0 0.91
A/J m 231.0 75.5   3 43.6 0.327 156.0, 307.0 -1.96
AKR/J m 749.0 262.0   7 99.0 0.35 335.0, 1198.0 -0.01
B6C3F1/J m 671.0 239.0   2   169.0 0.356 502.0, 840.0 -0.3
BALB/cByJ m 645.0 74.4   4 37.2 0.115 539.0, 705.0 -0.4
BTBR T+ Itpr3tf/J m 806.0 151.0   4 75.3 0.187 654.0, 988.0 0.21
BUB/BnJ m 1281.0 671.0   3 387.0 0.524 544.0, 1856.0 2.0
C3H/HeJ m 796.0 261.0   4 131.0 0.328 527.0, 1059.0 0.17
C57BL/10J m 907.0 499.0   4 249.0 0.55 218.0, 1401.0 0.59
C57BL/6J m 920.0 262.0   4 131.0 0.285 658.0, 1228.0 0.64
C57BLKS/J m 595.0 28.8   4 14.4 0.0484 568.0, 631.0 -0.59
C57BR/cdJ m 882.0 226.0   4 113.0 0.256 658.0, 1196.0 0.49
C57L/J m 776.0 77.2   3 44.5 0.0994 728.0, 865.0 0.09
CAST/EiJ m 432.0 160.0   4 80.2 0.371 225.0, 579.0 -1.2
CBA/J m 664.0 166.0   4 83.0 0.25 426.0, 806.0 -0.33
CZECHII/EiJ m 927.0 330.0   3 190.0 0.356 707.0, 1306.0 0.66
DBA/2J m 712.0 43.3   6 17.7 0.0608 658.0, 764.0 -0.15
FVB/NJ m 657.0 316.0   4 158.0 0.481 347.0, 1088.0 -0.36
JF1/MsJ m 1063.0 0.0   1   0.0 0.0 1063.0, 1063.0 1.18
KK/HlJ m 476.0 160.0   4 80.1 0.337 296.0, 676.0 -1.04
LP/J m 762.0 377.0   3 218.0 0.495 532.0, 1197.0 0.04
MA/MyJ m 1314.0 602.0   4 301.0 0.459 625.0, 2016.0 2.12
MSM/MsJ m 1529.0 95.0   3 54.9 0.0621 1471.0, 1639.0 2.94
NOD/ShiLtJ m 921.0 130.0   4 64.8 0.141 758.0, 1071.0 0.64
NON/ShiLtJ m 465.0 162.0   4 80.9 0.348 257.0, 652.0 -1.08
NZO/HlLtJ m 837.0 435.0   4 218.0 0.52 383.0, 1418.0 0.32
NZW/LacJ m 407.0 384.0   4 192.0 0.943 34.0, 784.0 -1.3
PERA/EiJ m 728.0 183.0   3 106.0 0.252 618.0, 940.0 -0.09
P/J m 722.0 498.0   2   352.0 0.689 370.0, 1074.0 -0.11
PL/J m 412.0 181.0   4 90.7 0.441 248.0, 620.0 -1.28
PWD/PhJ m 776.0 437.0   3 252.0 0.563 383.0, 1247.0 0.09
RIIIS/J m 768.0 80.7   4 40.3 0.105 684.0, 878.0 0.06
SEA/GnJ m 578.0 200.0   4 99.9 0.346 350.0, 837.0 -0.65
SJL/J m 700.0 210.0   4 105.0 0.3 507.0, 912.0 -0.19
SM/J m 468.0 255.0   4 128.0 0.546 209.0, 809.0 -1.07
SWR/J m 455.0 61.0   3 35.2 0.134 417.0, 525.0 -1.12
WSB/EiJ m 766.0 488.0   3 282.0 0.638 444.0, 1328.0 0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 992.6667 165.2908 1320.681 664.6524
A/J m 231.0 165.2908 559.0143 0.0
AKR/J m 748.8571 108.2083 963.5929 534.1214
B6C3F1/J m 671.0 202.4391 1072.7338 269.2662
BALB/cByJ m 644.75 143.1461 928.8187 360.6813
BTBR T+ Itpr3tf/J m 805.75 143.1461 1089.8187 521.6813
BUB/BnJ m 1281.3333 165.2908 1609.3476 953.319
C3H/HeJ m 795.75 143.1461 1079.8187 511.6813
C57BL/10J m 907.0 143.1461 1191.0687 622.9313
C57BL/6J m 920.5 143.1461 1204.5687 636.4313
C57BLKS/J m 595.0 143.1461 879.0687 310.9313
C57BR/cdJ m 882.0 143.1461 1166.0687 597.9313
C57L/J m 776.0 165.2908 1104.0143 447.9857
CAST/EiJ m 432.0 143.1461 716.0687 147.9313
CBA/J m 664.5 143.1461 948.5687 380.4313
CZECHII/EiJ m 927.0 165.2908 1255.0143 598.9857
DBA/2J m 711.8333 116.8783 943.7745 479.8922
FVB/NJ m 656.75 143.1461 940.8187 372.6813
KK/HlJ m 475.75 143.1461 759.8187 191.6813
LP/J m 762.0 165.2908 1090.0143 433.9857
MA/MyJ m 1313.5 143.1461 1597.5687 1029.4313
MSM/MsJ m 1529.3333 165.2908 1857.3476 1201.319
NOD/ShiLtJ m 921.25 143.1461 1205.3187 637.1813
NON/ShiLtJ m 465.25 143.1461 749.3187 181.1813
NZO/HlLtJ m 837.0 143.1461 1121.0687 552.9313
NZW/LacJ m 407.0 143.1461 691.0687 122.9313
PERA/EiJ m 728.3333 165.2908 1056.3476 400.319
P/J m 722.0 202.4391 1123.7338 320.2662
PL/J m 411.75 143.1461 695.8187 127.6813
PWD/PhJ m 776.3333 165.2908 1104.3476 448.319
RIIIS/J m 767.75 143.1461 1051.8187 483.6813
SEA/GnJ m 578.5 143.1461 862.5687 294.4313
SJL/J m 700.5 143.1461 984.5687 416.4313
SM/J m 467.5 143.1461 751.5687 183.4313
SWR/J m 454.6667 165.2908 782.681 126.6524
WSB/EiJ m 766.0 165.2908 1094.0143 437.9857




  GWAS USING LINEAR MIXED MODELS