Project measure / variable:   Threadgill1   CYP2E1_Rx300

ID, description, units MPD:19489   CYP2E1_Rx300   cytochrome P450 2E1 isoform   [pmol/mg]  post-Rx 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-12wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Threadgill1 - cytochrome P450 2E1 isoform post-Rx 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means74.0   pmol/mg
Median of the strain means67.9   pmol/mg
SD of the strain means± 27.6
Coefficient of variation (CV)0.373
Min–max range of strain means27.0   –   157   pmol/mg
Mean sample size per strain3.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 34 78698.278 2314.6552 0.8899 0.6404
Residuals 84 218475.9802 2600.9045


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 157.0 107.0   3 61.9 0.683 51.5, 266.0 3.01
A/J m 51.4 29.8   3 17.2 0.58 19.2, 78.0 -0.82
AKR/J m 61.7 37.8   7 14.3 0.612 24.3, 136.0 -0.45
B6C3F1/J m 55.3 0.283   2   0.2 0.00511 55.1, 55.5 -0.68
BALB/cByJ m 64.1 46.7   3 27.0 0.728 15.8, 109.0 -0.36
BTBR T+ Itpr3tf/J m 111.0 69.5   4 34.8 0.629 43.5, 208.0 1.34
BUB/BnJ m 50.3 63.1   3 36.4 1.25 10.0, 123.0 -0.86
C3H/HeJ m 51.8 48.0   3 27.7 0.925 6.44, 102.0 -0.8
C57BL/10J m 27.0 0.0   1   0.0 0.0 27.0, 27.0 -1.7
C57BL/6J m 68.2 30.8   2   21.8 0.451 46.5, 90.0 -0.21
C57BLKS/J m 93.9 14.1   4 7.07 0.151 75.6, 109.0 0.72
C57BR/cdJ m 53.3 42.8   4 21.4 0.802 9.6, 104.0 -0.75
C57L/J m 63.3 8.41   3 4.86 0.133 54.7, 71.5 -0.39
CAST/EiJ m 60.8 16.0   4 7.98 0.262 43.3, 76.5 -0.48
CBA/J m 63.8 41.2   4 20.6 0.647 16.5, 104.0 -0.37
CZECHII/EiJ m 70.6 28.2   3 16.3 0.4 38.0, 87.3 -0.12
DBA/2J m 67.9 59.3   4 29.7 0.874 7.25, 146.0 -0.22
FVB/NJ m 76.1 40.3   4 20.2 0.53 19.5, 110.0 0.08
JF1/MsJ m 123.0 42.6   3 24.6 0.345 93.0, 172.0 1.78
KK/HlJ m 38.3 18.9   4 9.45 0.493 13.3, 58.7 -1.29
LP/J m 89.7 46.1   3 26.6 0.514 42.0, 134.0 0.57
MA/MyJ m 74.5 75.1   4 37.5 1.01 20.2, 183.0 0.02
MSM/MsJ m 137.0 16.2   3 9.33 0.118 122.0, 154.0 2.28
NOD/ShiLtJ m 76.2 40.4   4 20.2 0.53 37.8, 133.0 0.08
NON/ShiLtJ m 62.7 37.9   4 18.9 0.604 38.8, 119.0 -0.41
NZO/HlLtJ m 83.9 75.4   4 37.7 0.899 38.5, 196.0 0.36
NZW/LacJ m 76.7 31.4   3 18.1 0.409 49.5, 111.0 0.1
PERA/EiJ m 53.0 65.8   2   46.5 1.24 6.5, 99.5 -0.76
P/J m 77.2 5.16   2   3.65 0.0669 73.5, 80.8 0.12
PL/J m 44.5 34.5   4 17.2 0.775 23.5, 96.0 -1.07
PWD/PhJ m 107.0 93.0   3 53.7 0.866 7.22, 191.0 1.2
RIIIS/J m 86.9 47.5   4 23.7 0.546 22.0, 135.0 0.47
SEA/GnJ m 79.4 43.3   2   30.6 0.545 48.8, 110.0 0.2
SJL/J m 62.1 74.5   4 37.2 1.2 1.0, 170.0 -0.43
SM/J m 51.0 0.0   1   0.0 0.0 51.0, 51.0 -0.83
SWR/J m 53.2 39.2   3 22.6 0.737 9.0, 83.8 -0.75
WSB/EiJ m 114.0 88.0   3 50.8 0.771 30.5, 206.0 1.45


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 157.1667 29.4443 215.7199 98.6134
A/J m 51.4 29.4443 109.9533 0.0
AKR/J m 61.7429 19.2758 100.075 23.4107
B6C3F1/J m 55.3 36.0618 127.0128 0.0
BALB/cByJ m 64.1 29.4443 122.6533 5.5467
BTBR T+ Itpr3tf/J m 110.625 25.4995 161.3336 59.9164
BUB/BnJ m 50.3333 29.4443 108.8866 0.0
C3H/HeJ m 51.8467 29.4443 110.3999 0.0
C57BL/6J m 68.25 36.0618 139.9628 0.0
C57BLKS/J m 93.9 25.4995 144.6086 43.1914
C57BR/cdJ m 53.325 25.4995 104.0336 2.6164
C57L/J m 63.3333 29.4443 121.8866 4.7801
CAST/EiJ m 60.825 25.4995 111.5336 10.1164
CBA/J m 63.75 25.4995 114.4586 13.0414
CZECHII/EiJ m 70.6 29.4443 129.1533 12.0467
DBA/2J m 67.8625 25.4995 118.5711 17.1539
FVB/NJ m 76.1 25.4995 126.8086 25.3914
JF1/MsJ m 123.3333 29.4443 181.8866 64.7801
KK/HlJ m 38.35 25.4995 89.0586 0.0
LP/J m 89.6667 29.4443 148.2199 31.1134
MA/MyJ m 74.525 25.4995 125.2336 23.8164
MSM/MsJ m 136.6667 29.4443 195.2199 78.1134
NOD/ShiLtJ m 76.2 25.4995 126.9086 25.4914
NON/ShiLtJ m 62.725 25.4995 113.4336 12.0164
NZO/HlLtJ m 83.875 25.4995 134.5836 33.1664
NZW/LacJ m 76.6667 29.4443 135.2199 18.1134
PERA/EiJ m 53.0 36.0618 124.7128 0.0
P/J m 77.15 36.0618 148.8628 5.4372
PL/J m 44.475 25.4995 95.1836 0.0
PWD/PhJ m 107.4067 29.4443 165.9599 48.8534
RIIIS/J m 86.875 25.4995 137.5836 36.1664
SEA/GnJ m 79.4 36.0618 151.1128 7.6872
SJL/J m 62.075 25.4995 112.7836 11.3664
SWR/J m 53.2 29.4443 111.7533 0.0
WSB/EiJ m 114.1667 29.4443 172.7199 55.6134




  GWAS USING LINEAR MIXED MODELS