Project measure / variable:   Threadgill1   CYP1A2_Rx300

ID, description, units MPD:19488   CYP1A2_Rx300   cytochrome P450 1A2 isoform   [pmol/mg]  post-Rx 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-12wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Threadgill1 - cytochrome P450 1A2 isoform post-Rx 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means148   pmol/mg
Median of the strain means148   pmol/mg
SD of the strain means± 50.3
Coefficient of variation (CV)0.339
Min–max range of strain means34.5   –   288   pmol/mg
Mean sample size per strain3.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 36 277835.5595 7717.6544 1.1233 0.3241
Residuals 88 604598.3996 6870.4364


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 288.0 96.8   3 55.9 0.336 206.0, 395.0 2.78
A/J m 67.2 68.4   3 39.5 1.02 23.2, 146.0 -1.61
AKR/J m 148.0 63.4   7 24.0 0.429 68.0, 241.0 0.0
B6C3F1/J m 190.0 52.3   2   37.0 0.275 153.0, 227.0 0.83
BALB/cByJ m 171.0 67.9   3 39.2 0.398 110.0, 244.0 0.46
BTBR T+ Itpr3tf/J m 176.0 53.8   4 26.9 0.306 127.0, 248.0 0.55
BUB/BnJ m 134.0 92.2   3 53.2 0.69 63.0, 238.0 -0.28
C3H/HeJ m 161.0 32.5   2   23.0 0.202 138.0, 184.0 0.26
C57BL/10J m 34.5 32.6   3 18.8 0.947 12.0, 71.9 -2.26
C57BL/6J m 112.0 114.0   4 56.9 1.02 3.8, 228.0 -0.72
C57BLKS/J m 203.0 38.2   4 19.1 0.188 170.0, 258.0 1.09
C57BR/cdJ m 119.0 33.7   3 19.4 0.283 83.2, 150.0 -0.58
C57L/J m 122.0 43.2   3 25.0 0.355 72.0, 151.0 -0.52
CAST/EiJ m 124.0 7.9   4 3.95 0.0634 118.0, 136.0 -0.48
CBA/J m 56.9 12.8   3 7.39 0.225 48.4, 71.6 -1.82
CZECHII/EiJ m 149.0 82.2   3 47.5 0.552 67.6, 232.0 0.02
DBA/2J m 141.0 89.1   6 36.4 0.634 33.4, 244.0 -0.14
FVB/NJ m 143.0 151.0   4 75.5 1.06 12.1, 288.0 -0.1
JF1/MsJ m 228.0 82.0   3 47.3 0.359 140.0, 302.0 1.59
KK/HlJ m 126.0 82.1   4 41.1 0.652 10.9, 197.0 -0.44
LP/J m 145.0 101.0   3 58.0 0.693 45.0, 246.0 -0.06
MA/MyJ m 216.0 53.8   4 26.9 0.249 139.0, 264.0 1.35
MSM/MsJ m 221.0 34.1   3 19.7 0.155 199.0, 260.0 1.45
NOD/ShiLtJ m 152.0 96.9   4 48.4 0.638 70.5, 292.0 0.08
NON/ShiLtJ m 176.0 72.6   3 41.9 0.413 91.8, 218.0 0.55
NZO/HlLtJ m 157.0 124.0   4 61.9 0.791 3.25, 305.0 0.18
NZW/LacJ m 153.0 31.9   3 18.4 0.208 132.0, 190.0 0.1
PERA/EiJ m 137.0 166.0   2   117.0 1.21 19.4, 254.0 -0.22
P/J m 112.0 17.3   2   12.2 0.155 99.5, 124.0 -0.72
PL/J m 120.0 52.4   4 26.2 0.438 81.2, 196.0 -0.56
PWD/PhJ m 209.0 134.0   3 77.2 0.64 87.0, 352.0 1.21
RIIIS/J m 176.0 83.4   4 41.7 0.474 61.5, 258.0 0.55
SEA/GnJ m 83.8 66.4   3 38.4 0.793 11.4, 142.0 -1.28
SJL/J m 135.0 97.9   4 48.9 0.726 4.0, 217.0 -0.26
SM/J m 79.5 53.0   2   37.5 0.667 42.0, 117.0 -1.37
SWR/J m 152.0 81.6   3 47.1 0.538 59.5, 215.0 0.08
WSB/EiJ m 163.0 145.0   3 83.9 0.893 27.0, 316.0 0.3


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 288.3333 47.8555 383.436 193.2307
A/J m 67.2333 47.8555 162.336 0.0
AKR/J m 147.8143 31.3288 210.0736 85.555
B6C3F1/J m 190.0 58.6107 306.4765 73.5235
BALB/cByJ m 170.6667 47.8555 265.7693 75.564
BTBR T+ Itpr3tf/J m 175.75 41.444 258.1113 93.3887
BUB/BnJ m 133.6667 47.8555 228.7693 38.564
C3H/HeJ m 161.0 58.6107 277.4765 44.5235
C57BL/10J m 34.4667 47.8555 129.5693 0.0
C57BL/6J m 111.7 41.444 194.0613 29.3387
C57BLKS/J m 202.75 41.444 285.1113 120.3887
C57BR/cdJ m 119.0667 47.8555 214.1693 23.964
C57L/J m 121.6667 47.8555 216.7693 26.564
CAST/EiJ m 124.5 41.444 206.8613 42.1387
CBA/J m 56.8667 47.8555 151.9693 0.0
CZECHII/EiJ m 148.8667 47.8555 243.9693 53.764
DBA/2J m 140.5333 33.8389 207.7811 73.2856
FVB/NJ m 142.65 41.444 225.0113 60.2887
JF1/MsJ m 228.3333 47.8555 323.436 133.2307
KK/HlJ m 125.975 41.444 208.3363 43.6137
LP/J m 145.0 47.8555 240.1027 49.8973
MA/MyJ m 216.25 41.444 298.6113 133.8887
MSM/MsJ m 220.6667 47.8555 315.7693 125.564
NOD/ShiLtJ m 151.875 41.444 234.2363 69.5137
NON/ShiLtJ m 175.6 47.8555 270.7027 80.4973
NZO/HlLtJ m 156.5625 41.444 238.9238 74.2012
NZW/LacJ m 153.3333 47.8555 248.436 58.2307
PERA/EiJ m 136.7 58.6107 253.1765 20.2235
P/J m 111.75 58.6107 228.2265 0.0
PL/J m 119.55 41.444 201.9113 37.1887
PWD/PhJ m 209.0 47.8555 304.1027 113.8973
RIIIS/J m 175.875 41.444 258.2363 93.5137
SEA/GnJ m 83.7667 47.8555 178.8693 0.0
SJL/J m 134.75 41.444 217.1113 52.3887
SM/J m 79.5 58.6107 195.9765 0.0
SWR/J m 151.5 47.8555 246.6027 56.3973
WSB/EiJ m 162.6667 47.8555 257.7693 67.564




  GWAS USING LINEAR MIXED MODELS