Project measure / variable:   Threadgill1   CYP2E1_ctrl

ID, description, units MPD:19484   CYP2E1_ctrl   cytochrome P450 2E1 isoform   [pmol/mg]  control  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-12wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Threadgill1 - cytochrome P450 2E1 isoform control



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means113   pmol/mg
Median of the strain means112   pmol/mg
SD of the strain means± 39.5
Coefficient of variation (CV)0.348
Min–max range of strain means19.0   –   217   pmol/mg
Mean sample size per strain1.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 28 62668.5764 2238.1634 0.4788 0.9745
Residuals 32 149599.6617 4674.9894


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 152.0 107.0   2   75.5 0.705 76.0, 227.0 0.98
A/J m 130.0 0.0   2   0.0 0.0 130.0, 130.0 0.42
AKR/J m 112.0 24.7   2   17.5 0.22 95.0, 130.0 -0.04
B6C3F1/J m 122.0 0.0   1   0.0 0.0 122.0, 122.0 0.22
BALB/cByJ m 103.0 100.0   2   70.8 0.969 32.5, 174.0 -0.26
BTBR T+ Itpr3tf/J m 91.7 50.0   2   35.3 0.545 56.3, 127.0 -0.55
BUB/BnJ m 112.0 0.0   1   0.0 0.0 112.0, 112.0 -0.04
C3H/HeJ m 80.7 6.86   2   4.85 0.085 75.8, 85.5 -0.83
C57BL/10J m 105.0 32.7   2   23.2 0.312 81.7, 128.0 -0.21
C57BL/6J m 144.0 96.2   2   68.0 0.668 76.0, 212.0 0.77
C57BLKS/J m 96.0 12.7   2   9.0 0.133 87.0, 105.0 -0.44
C57BR/cdJ m 108.0 104.0   2   73.8 0.963 34.5, 182.0 -0.14
C57L/J m 35.0 15.6   2   11.0 0.444 24.0, 46.0 -1.99
CAST/EiJ m 19.0 0.0   1   0.0 0.0 19.0, 19.0 -2.39
CBA/J m 112.0 76.4   2   54.0 0.682 58.0, 166.0 -0.04
CZECHII/EiJ m 59.0 63.6   2   45.0 1.08 14.0, 104.0 -1.38
DBA/2J m 102.0 42.8   2   30.2 0.42 71.5, 132.0 -0.29
FVB/NJ m 51.2 0.0   1   0.0 0.0 51.2, 51.2 -1.58
JF1/MsJ m 169.0 117.0   2   82.7 0.691 86.5, 252.0 1.41
KK/HlJ m 118.0 49.1   2   34.8 0.416 83.5, 153.0 0.11
LP/J m 88.2 31.2   3 18.0 0.353 67.5, 124.0 -0.64
MA/MyJ m 140.0 0.0   1   0.0 0.0 140.0, 140.0 0.67
MSM/MsJ m 162.0 52.3   2   37.0 0.323 125.0, 199.0 1.23
NOD/ShiLtJ m 199.0 132.0   2   93.0 0.661 106.0, 292.0 2.16
NON/ShiLtJ m 134.0 0.0   1   0.0 0.0 134.0, 134.0 0.52
NZO/HlLtJ m 114.0 49.1   2   34.8 0.43 79.5, 149.0 0.01
NZW/LacJ m 117.0 43.0   2   30.4 0.369 86.2, 147.0 0.09
PERA/EiJ m 120.0 83.3   3 48.1 0.692 49.2, 212.0 0.17
P/J m 118.0 79.9   2   56.5 0.68 61.0, 174.0 0.11
PL/J m 84.0 53.7   2   38.0 0.64 46.0, 122.0 -0.75
PWD/PhJ m 147.0 49.5   2   35.0 0.337 112.0, 182.0 0.85
RIIIS/J m 217.0 0.0   1   0.0 0.0 217.0, 217.0 2.62
SEA/GnJ m 103.0 89.4   2   63.2 0.871 39.5, 166.0 -0.26
SJL/J m 77.5 74.2   2   52.4 0.956 25.1, 130.0 -0.91
SM/J m 136.0 0.0   1   0.0 0.0 136.0, 136.0 0.57
SWR/J m 104.0 71.4   3 41.2 0.687 25.0, 164.0 -0.24
WSB/EiJ m 116.0 7.78   2   5.5 0.0673 110.0, 121.0 0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 151.5 48.3476 249.9809 53.0191
A/J m 130.0 48.3476 228.4809 31.5191
AKR/J m 112.5 48.3476 210.9809 14.0191
BALB/cByJ m 103.25 48.3476 201.7309 4.7691
BTBR T+ Itpr3tf/J m 91.65 48.3476 190.1309 0.0
C3H/HeJ m 80.65 48.3476 179.1309 0.0
C57BL/10J m 104.85 48.3476 203.3309 6.3691
C57BL/6J m 144.0 48.3476 242.4809 45.5191
C57BLKS/J m 96.0 48.3476 194.4809 0.0
C57BR/cdJ m 108.25 48.3476 206.7309 9.7691
C57L/J m 35.0 48.3476 133.4809 0.0
CBA/J m 112.0 48.3476 210.4809 13.5191
CZECHII/EiJ m 59.0 48.3476 157.4809 0.0
DBA/2J m 101.75 48.3476 200.2309 3.2691
JF1/MsJ m 169.25 48.3476 267.7309 70.7691
KK/HlJ m 118.25 48.3476 216.7309 19.7691
LP/J m 88.1667 39.4757 168.576 7.7573
MSM/MsJ m 162.0 48.3476 260.4809 63.5191
NOD/ShiLtJ m 199.0 48.3476 297.4809 100.5191
NZO/HlLtJ m 114.25 48.3476 212.7309 15.7691
NZW/LacJ m 116.6 48.3476 215.0809 18.1191
PERA/EiJ m 120.4 39.4757 200.8093 39.9907
P/J m 117.5 48.3476 215.9809 19.0191
PL/J m 84.0 48.3476 182.4809 0.0
PWD/PhJ m 147.0 48.3476 245.4809 48.5191
SEA/GnJ m 102.75 48.3476 201.2309 4.2691
SJL/J m 77.55 48.3476 176.0309 0.0
SWR/J m 104.0 39.4757 184.4093 23.5907
WSB/EiJ m 115.5 48.3476 213.9809 17.0191




  GWAS USING LINEAR MIXED MODELS