Project measure / variable:   Threadgill1   GSH_total_Rx300

ID, description, units MPD:19479   GSH_total_Rx300   total glutathione (GSH plus GSSG)   [µmol/g]  post-Rx 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   36 strains     sex: m     age: 8-17wks
Procedure metabolite quantification
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  STRAIN COMPARISON PLOT
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Threadgill1 - total glutathione (GSH plus GSSG) post-Rx 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means2.73   µmol/g
Median of the strain means2.37   µmol/g
SD of the strain means± 1.25
Coefficient of variation (CV)0.458
Min–max range of strain means0.651   –   5.26   µmol/g
Mean sample size per strain3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 34 199.8294 5.8773 3.7138 < 0.0001
Residuals 100 158.2546 1.5825


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 3.15 2.48   5 1.11 0.787 1.0, 7.33 0.34
A/J m 2.38 1.01   4 0.506 0.425 1.4, 3.76 -0.28
AKR/J m 2.54 0.976   4 0.488 0.384 1.82, 3.98 -0.15
B6C3F1/J m 3.3 1.05   4 0.526 0.319 2.38, 4.82 0.46
BALB/cByJ m 0.651 0.134   4 0.067 0.206 0.542, 0.817 -1.66
BTBR T+ Itpr3tf/J m 1.9 0.73   3 0.422 0.384 1.16, 2.62 -0.66
BUB/BnJ m 3.0 0.875   4 0.438 0.292 2.29, 4.23 0.22
C3H/HeJ m 2.14 0.281   4 0.14 0.131 1.74, 2.34 -0.47
C57BL/10J m 1.16 0.99   4 0.495 0.85 0.224, 2.03 -1.26
C57BL/6J m 1.87 1.35   4 0.673 0.721 0.42, 3.48 -0.69
C57BLKS/J m 2.36 0.574   4 0.287 0.243 1.92, 3.2 -0.3
C57BR/cdJ m 3.27 1.9   4 0.952 0.582 1.46, 5.9 0.43
C57L/J m 1.36 1.06   4 0.532 0.784 -1.1
CAST/EiJ m 4.48 1.5   3 0.865 0.334 3.59, 6.21 1.4
CBA/J m 2.2 0.846   4 0.423 0.385 1.58, 3.44 -0.42
CZECHII/EiJ m 3.77 3.14   3 1.81 0.833 0.269, 6.33 0.83
DBA/2J m 1.94 1.02   4 0.512 0.527 1.06, 3.39 -0.63
FVB/NJ m 1.96 0.708   4 0.354 0.361 1.45, 2.97 -0.62
JF1/MsJ m 2.71 2.06   3 1.19 0.759 0.377, 4.26 -0.02
KK/HlJ m 1.25 0.404   3 0.233 0.322 0.787, 1.51 -1.18
LP/J m 1.63 0.565   4 0.282 0.347 1.16, 2.44 -0.88
MA/MyJ m 3.08 1.31   3 0.758 0.427 2.16, 4.58 0.28
MSM/MsJ m 4.8 1.78   4 0.888 0.37 2.94, 6.85 1.66
NOD/ShiLtJ m 5.26 1.45   4 0.725 0.276 3.39, 6.45 2.03
NON/ShiLtJ m 1.93 0.95   4 0.475 0.493 1.23, 3.28 -0.64
NZO/HlLtJ m 1.59 0.496   5 0.222 0.312 1.23, 2.17 -0.91
NZW/LacJ m 1.85 1.16   5 0.519 0.627 0.936, 3.56 -0.7
PERA/EiJ m 4.61 1.53   4 0.764 0.332 2.95, 6.44 1.51
PL/J m 1.84 1.05   4 0.523 0.569 0.826, 2.96 -0.71
PWD/PhJ m 4.24 1.05   4 0.524 0.247 3.08, 5.51 1.21
RIIIS/J m 5.02 1.16   4 0.578 0.23 3.58, 6.16 1.83
SEA/GnJ m 4.95 1.05   3 0.607 0.212 3.76, 5.74 1.78
SJL/J m 2.84 0.434   4 0.217 0.153 2.51, 3.43 0.09
SM/J m 3.85 0.472   3 0.273 0.123 3.31, 4.2 0.9
SWR/J m 2.02 1.57   4 0.784 0.776 0.355, 4.12 -0.57
WSB/EiJ m 1.34 0.0   1   0.0 0.0 1.34, 1.34 -1.11


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 3.146 0.5626 4.2622 2.0298
A/J m 2.38 0.629 3.6279 1.1321
AKR/J m 2.5425 0.629 3.7904 1.2946
B6C3F1/J m 3.305 0.629 4.5529 2.0571
BALB/cByJ m 0.6508 0.629 1.8987 0.0
BTBR T+ Itpr3tf/J m 1.9033 0.7263 3.3443 0.4624
BUB/BnJ m 2.9975 0.629 4.2454 1.7496
C3H/HeJ m 2.1375 0.629 3.3854 0.8896
C57BL/10J m 1.1645 0.629 2.4124 0.0
C57BL/6J m 1.8675 0.629 3.1154 0.6196
C57BLKS/J m 2.36 0.629 3.6079 1.1121
C57BR/cdJ m 3.27 0.629 4.5179 2.0221
C57L/J m 1.3575 0.629 2.6054 0.1096
CAST/EiJ m 4.48 0.7263 5.921 3.039
CBA/J m 2.1975 0.629 3.4454 0.9496
CZECHII/EiJ m 3.7663 0.7263 5.2073 2.3254
DBA/2J m 1.94 0.629 3.1879 0.6921
FVB/NJ m 1.96 0.629 3.2079 0.7121
JF1/MsJ m 2.7123 0.7263 4.1533 1.2714
KK/HlJ m 1.2523 0.7263 2.6933 0.0
LP/J m 1.6275 0.629 2.8754 0.3796
MA/MyJ m 3.0767 0.7263 4.5176 1.6357
MSM/MsJ m 4.805 0.629 6.0529 3.5571
NOD/ShiLtJ m 5.2575 0.629 6.5054 4.0096
NON/ShiLtJ m 1.9275 0.629 3.1754 0.6796
NZO/HlLtJ m 1.592 0.5626 2.7082 0.4758
NZW/LacJ m 1.8488 0.5626 2.965 0.7326
PERA/EiJ m 4.605 0.629 5.8529 3.3571
PL/J m 1.839 0.629 3.0869 0.5911
PWD/PhJ m 4.2425 0.629 5.4904 2.9946
RIIIS/J m 5.0225 0.629 6.2704 3.7746
SEA/GnJ m 4.9533 0.7263 6.3943 3.5124
SJL/J m 2.8425 0.629 4.0904 1.5946
SM/J m 3.8467 0.7263 5.2876 2.4057
SWR/J m 2.0188 0.629 3.2667 0.7708




  GWAS USING LINEAR MIXED MODELS