Project measure / variable:   Threadgill1   liver_necrosis_Rx300

ID, description, units MPD:19465   liver_necrosis_Rx300   necrosis   [%]  dose: 300 mg/kg  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-17wks
Procedure histopathology
Ontology mappings

  STRAIN COMPARISON PLOT
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Threadgill1 - necrosis dose: 300 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means27.5   %
Median of the strain means26.3   %
SD of the strain means± 18.1
Coefficient of variation (CV)0.658
Min–max range of strain means0   –   82.3   %
Mean sample size per strain3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 36 40913.4562 1136.4849 1.6928 0.0208
Residuals 104 69820.3452 671.3495


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 31.2 43.4   4 21.7 1.39 0.21
A/J m 13.0 26.0   4 13.0 2.0 -0.8
AKR/J m 28.7 31.1   7 11.8 1.08 0.07
B6C3F1/J m 82.3 17.2   3 9.91 0.208 64.0, 98.0 3.03
BALB/cByJ m 32.5 21.7   4 10.9 0.669 0.28
BTBR T+ Itpr3tf/J m 12.0 19.6   4 9.81 1.63 -0.86
BUB/BnJ m 43.7 25.8   3 14.9 0.591 14.0, 61.0 0.9
C3H/HeJ m 55.2 22.6   4 11.3 0.41 32.0, 78.0 1.53
C57BL/10J m 40.5 47.2   4 23.6 1.17 0.72
C57BL/6J m 22.0 26.2   4 13.1 1.19 -0.3
C57BLKS/J m 22.0 15.4   4 7.71 0.701 1.0, 38.0 -0.3
C57BR/cdJ m 30.8 40.3   4 20.1 1.31 7.0, 91.0 0.18
C57L/J m 6.5 3.54   2   2.5 0.544 4.0, 9.0 -1.16
CAST/EiJ m 0.0 0.0   4 0.0 0.0 -1.52
CBA/J m 70.5 36.8   4 18.4 0.522 21.0, 100.0 2.38
CZECHII/EiJ m 5.0 8.66   3 5.0 1.73 -1.24
DBA/2J m 33.5 19.3   6 7.9 0.578 2.0, 58.0 0.33
FVB/NJ m 30.0 23.9   4 12.0 0.798 0.14
JF1/MsJ m 37.2 21.5   4 10.8 0.578 10.0, 55.0 0.54
KK/HlJ m 45.8 15.9   4 7.97 0.349 25.0, 61.0 1.01
LP/J m 10.7 15.9   3 9.21 1.5 -0.93
MA/MyJ m 19.0 24.7   4 12.4 1.3 -0.47
MSM/MsJ m 47.0 44.0   3 25.4 0.937 2.0, 90.0 1.08
NOD/ShiLtJ m 5.33 9.24   3 5.33 1.73 -1.22
NON/ShiLtJ m 18.8 6.65   4 3.33 0.355 13.0, 28.0 -0.48
NZO/HlLtJ m 6.25 8.1   4 4.05 1.3 -1.17
NZW/LacJ m 45.8 31.7   4 15.9 0.693 1.01
PERA/EiJ m 26.3 36.5   3 21.1 1.39 -0.07
P/J m 39.2 27.5   4 13.8 0.701 2.0, 66.0 0.65
PL/J m 10.7 10.1   3 5.81 0.944 -0.93
PWD/PhJ m 18.5 24.5   4 12.3 1.33 -0.5
RIIIS/J m 19.2 16.0   4 7.99 0.83 -0.46
SEA/GnJ m 27.2 17.9   4 8.95 0.657 8.0, 47.0 -0.02
SJL/J m 21.5 25.3   4 12.7 1.18 -0.33
SM/J m 17.5 33.7   4 16.8 1.92 -0.55
SWR/J m 13.3 13.7   3 7.88 1.02 4.0, 29.0 -0.78
WSB/EiJ m 28.0 30.8   3 17.8 1.1 0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 31.25 12.9552 56.9407 5.5593
A/J m 13.0 12.9552 38.6907 -12.6907
AKR/J m 28.7143 9.7932 48.1346 9.294
B6C3F1/J m 82.3333 14.9594 111.9984 52.6683
BALB/cByJ m 32.5 12.9552 58.1907 6.8093
BTBR T+ Itpr3tf/J m 12.0 12.9552 37.6907 -13.6907
BUB/BnJ m 43.6667 14.9594 73.3317 14.0016
C3H/HeJ m 55.25 12.9552 80.9407 29.5593
C57BL/10J m 40.5 12.9552 66.1907 14.8093
C57BL/6J m 22.0 12.9552 47.6907 -3.6907
C57BLKS/J m 22.0 12.9552 47.6907 -3.6907
C57BR/cdJ m 30.75 12.9552 56.4407 5.0593
C57L/J m 6.5 18.3214 42.8321 -29.8321
CAST/EiJ m 0.0 12.9552 25.6907 -25.6907
CBA/J m 70.5 12.9552 96.1907 44.8093
CZECHII/EiJ m 5.0 14.9594 34.665 -24.665
DBA/2J m 33.5 10.5779 54.4763 12.5237
FVB/NJ m 30.0 12.9552 55.6907 4.3093
JF1/MsJ m 37.25 12.9552 62.9407 11.5593
KK/HlJ m 45.75 12.9552 71.4407 20.0593
LP/J m 10.6667 14.9594 40.3317 -18.9984
MA/MyJ m 19.0 12.9552 44.6907 -6.6907
MSM/MsJ m 47.0 14.9594 76.665 17.335
NOD/ShiLtJ m 5.3333 14.9594 34.9984 -24.3317
NON/ShiLtJ m 18.75 12.9552 44.4407 -6.9407
NZO/HlLtJ m 6.25 12.9552 31.9407 -19.4407
NZW/LacJ m 45.75 12.9552 71.4407 20.0593
PERA/EiJ m 26.3333 14.9594 55.9984 -3.3317
P/J m 39.25 12.9552 64.9407 13.5593
PL/J m 10.6667 14.9594 40.3317 -18.9984
PWD/PhJ m 18.5 12.9552 44.1907 -7.1907
RIIIS/J m 19.25 12.9552 44.9407 -6.4407
SEA/GnJ m 27.25 12.9552 52.9407 1.5593
SJL/J m 21.5 12.9552 47.1907 -4.1907
SM/J m 17.5 12.9552 43.1907 -8.1907
SWR/J m 13.3333 14.9594 42.9984 -16.3317
WSB/EiJ m 28.0 14.9594 57.665 -1.665




  GWAS USING LINEAR MIXED MODELS