Project measure / variable:   Schulz1   D_CO

ID, description, units MPD:1618   D_CO   diffusing capacity: carbon monoxide   [µmol/min/hPa]  
Data set, strains Schulz1   inbred   7 strains     sex: both     age: 12-14wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Schulz1 - diffusing capacity: carbon monoxide



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means12.7   µmol/min/hPa 14.2   µmol/min/hPa
Median of the strain means11.8   µmol/min/hPa 13.8   µmol/min/hPa
SD of the strain means± 1.90 ± 2.13
Coefficient of variation (CV)0.149 0.149
Min–max range of strain means11.1   –   15.7   µmol/min/hPa 11.8   –   17.8   µmol/min/hPa
Mean sample size per strain14.6   mice 14.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 110.0181 110.0181 92.9089 < 0.0001
strain 6 713.7686 118.9614 100.4614 < 0.0001
sex:strain 6 21.3999 3.5666 3.012 0.0078
Residuals 188 222.6204 1.1842


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 11.8 0.547   15 0.141 0.0463 10.9, 12.7 -0.5
129S1/SvImJ m 12.9 0.615   15 0.159 0.0475 11.6, 14.0 -0.63
A/J f 11.7 0.777   16 0.194 0.0665 10.1, 13.1 -0.55
A/J m 12.9 0.972   14 0.26 0.0756 10.7, 14.1 -0.63
BALB/cByJ f 15.2 1.05   15 0.27 0.069 13.3, 17.1 1.29
BALB/cByJ m 16.4 1.09   16 0.272 0.0663 13.8, 18.6 1.02
C3H/HeJ f 12.4 1.09   13 0.303 0.0881 11.2, 14.6 -0.18
C3H/HeJ m 14.1 1.89   12 0.546 0.134 10.5, 18.1 -0.07
C57BL/6J f 11.1 0.554   14 0.148 0.0498 10.1, 11.9 -0.86
C57BL/6J m 13.8 1.07   12 0.307 0.0772 11.6, 14.9 -0.21
FVB/NJ f 15.7 1.81   16 0.452 0.115 9.27, 17.0 1.56
FVB/NJ m 17.8 1.12   15 0.288 0.0626 14.5, 19.1 1.67
SWR/J f 11.3 1.04   13 0.289 0.0921 9.91, 13.5 -0.76
SWR/J m 11.8 0.777   16 0.194 0.0656 9.17, 12.5 -1.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 11.8067 0.281 12.3609 11.2524
129S1/SvImJ m 12.9333 0.281 13.4876 12.3791
A/J f 11.6813 0.272 12.2179 11.1446
A/J m 12.8571 0.2908 13.4309 12.2834
BALB/cByJ f 15.1667 0.281 15.7209 14.6124
BALB/cByJ m 16.4 0.272 16.9367 15.8633
C3H/HeJ f 12.4077 0.3018 13.0031 11.8123
C3H/HeJ m 14.1167 0.3141 14.7363 13.497
C57BL/6J f 11.1357 0.2908 11.7094 10.562
C57BL/6J m 13.8 0.3141 14.4197 13.1803
FVB/NJ f 15.6731 0.272 16.2098 15.1365
FVB/NJ m 17.8333 0.281 18.3876 17.2791
SWR/J f 11.3085 0.3018 11.9038 10.7131
SWR/J m 11.8481 0.272 12.3848 11.3115


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 12.37 0.1987 12.7619 11.9781
A/J both 12.2692 0.1991 12.662 11.8764
BALB/cByJ both 15.7833 0.1955 16.1691 15.3976
C3H/HeJ both 13.2622 0.2178 13.6918 12.8325
C57BL/6J both 12.4679 0.214 12.8901 12.0456
FVB/NJ both 16.7532 0.1955 17.139 16.3675
SWR/J both 11.5783 0.2032 11.9791 11.1775




  GWAS USING LINEAR MIXED MODELS