Project measure / variable:   Auwerx2   ldl_HFD

ID, description, units MPD:114690   ldl_HFD   plasma LDL amount   [mmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma LDL amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means0.21339   mmol/L 0.14456   mmol/L
Median of the strain means0.13   mmol/L 0.108   mmol/L
SD of the strain means± 0.17486 ± 0.13986
Coefficient of variation (CV)0.8195 0.9675
Min–max range of strain means0.054   –   0.544   mmol/L 0.0175   –   0.39   mmol/L
Mean sample size per strain4.9   mice 3.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0469 0.0469 26.8782 < 0.0001
strain 7 0.5387 0.077 44.0803 < 0.0001
sex:strain 7 0.3948 0.0564 32.3063 < 0.0001
Residuals 55 0.096 0.0017


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.136 0.01673   5 0.00748331 0.123 0.11, 0.15 -0.44
129S1/SvImJ m 0.045 0.00707107   2   0.005 0.1571 0.04, 0.05 -0.71
A/J f 0.1075 0.025   4 0.0125 0.2326 0.08, 0.14 -0.61
A/J m 0.056 0.0114   5 0.00509902 0.2036 0.04, 0.07 -0.63
C57BL/6J f 0.13 0.01732   3 0.01 0.1332 0.11, 0.14 -0.48
C57BL/6J m 0.3775 0.10436   4 0.05218 0.2765 0.27, 0.52 1.67
CAST/EiJ f 0.418 0.04764   5 0.02131 0.114 0.35, 0.47 1.17
CAST/EiJ m 0.115 0.02121   2   0.015 0.1845 0.1, 0.13 -0.21
DBA/2J f 0.054 0.03209   5 0.01435 0.5943 0.02, 0.1 -0.91
DBA/2J m 0.108 0.03033   5 0.01356 0.2808 0.07, 0.15 -0.26
NOD/ShiLtJ f 0.101 0.03843   10 0.01215 0.3805 0.04, 0.17 -0.64
NOD/ShiLtJ m 0.12 0.02236   5 0.01 0.1863 0.09, 0.15 -0.18
NZO/HlLtJ f 0.544 0.06148   5 0.0275 0.113 0.49, 0.61 1.89
NZO/HlLtJ m 0.39 0.0   1   0.0 0.0 0.39, 0.39 1.75
PWK/PhJ f 0.34 0.09129   4 0.04564 0.2685 0.26, 0.47 0.72
PWK/PhJ m 0.072 0.01304   5 0.00583095 0.1811 0.06, 0.09 -0.52
WSB/EiJ f 0.09 0.01   3 0.0057735 0.1111 0.08, 0.1 -0.71
WSB/EiJ m 0.0175 0.015   4 0.0075 0.8571 -0.91


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.136 0.0186854343 0.1734464471 0.0985535529
129S1/SvImJ m 0.045 0.0295442657 0.1042080316 -0.0142080316
A/J f 0.1075 0.0208909506 0.1493664006 0.0656335994
A/J m 0.056 0.0186854343 0.0934464471 0.0185535529
C57BL/6J f 0.13 0.0241227919 0.1783431553 0.0816568447
C57BL/6J m 0.3775 0.0208909506 0.4193664006 0.3356335994
CAST/EiJ f 0.418 0.0186854343 0.4554464471 0.3805535529
CAST/EiJ m 0.115 0.0295442657 0.1742080316 0.0557919684
DBA/2J f 0.054 0.0186854343 0.0914464471 0.0165535529
DBA/2J m 0.108 0.0186854343 0.1454464471 0.0705535529
NOD/ShiLtJ f 0.101 0.0132125973 0.1274786367 0.0745213633
NOD/ShiLtJ m 0.12 0.0186854343 0.1574464471 0.0825535529
PWK/PhJ f 0.34 0.0208909506 0.3818664006 0.2981335994
PWK/PhJ m 0.072 0.0186854343 0.1094464471 0.0345535529
WSB/EiJ f 0.09 0.0241227919 0.1383431553 0.0416568447
WSB/EiJ m 0.0175 0.0208909506 0.0593664006 -0.0243664006


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.0905 0.0174786233 0.1255279439 0.0554720561
A/J both 0.08175 0.0140140757 0.1098348353 0.0536651647
C57BL/6J both 0.25375 0.0159557271 0.2857259917 0.2217740083
CAST/EiJ both 0.2665 0.0174786233 0.3015279439 0.2314720561
DBA/2J both 0.081 0.0132125973 0.1074786367 0.0545213633
NOD/ShiLtJ both 0.1105 0.0114424449 0.133431172 0.087568828
PWK/PhJ both 0.206 0.0140140757 0.2340848353 0.1779151647
WSB/EiJ both 0.05375 0.0159557271 0.0857259917 0.0217740083




  GWAS USING LINEAR MIXED MODELS