Project measure / variable:   Auwerx2   lactate_HFD

ID, description, units MPD:114682   lactate_HFD   plasma lactate amount   [mmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma lactate amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means3.3324   mmol/L 2.9161   mmol/L
Median of the strain means3.5   mmol/L 2.9   mmol/L
SD of the strain means± 1.1678 ± 1.1769
Coefficient of variation (CV)0.3504 0.4036
Min–max range of strain means1.62   –   5.66   mmol/L 1.6   –   5.42   mmol/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.121 0.121 0.1257 0.7242
strain 7 55.8081 7.9726 8.2817 < 0.0001
sex:strain 7 11.1677 1.5954 1.6572 0.1386
Residuals 56 53.9097 0.9627


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2.24 0.74364   5 0.33257 0.332 1.5, 3.2 -0.94
129S1/SvImJ m 1.7 0.14142   2   0.1 0.0832 1.6, 1.8 -1.03
A/J f 3.9 0.8756   4 0.4378 0.2245 3.0, 4.7 0.49
A/J m 5.42 0.91214   5 0.40792 0.1683 4.4, 6.4 2.13
C57BL/6J f 3.7 0.7   3 0.40415 0.1892 2.9, 4.2 0.31
C57BL/6J m 2.825 0.74106   4 0.37053 0.2623 2.2, 3.9 -0.08
CAST/EiJ f 1.62 0.35637   5 0.15937 0.22 1.3, 2.2 -1.47
CAST/EiJ m 1.6 0.14142   2   0.1 0.0884 1.5, 1.7 -1.12
DBA/2J f 3.78 1.4446   5 0.64607 0.3822 2.6, 6.1 0.38
DBA/2J m 2.94 0.77006   5 0.34438 0.2619 1.7, 3.7 0.02
NOD/ShiLtJ f 3.5 1.2587   10 0.39805 0.3596 1.5, 6.1 0.14
NOD/ShiLtJ m 3.0 0.82462   5 0.36878 0.2749 2.1, 3.7 0.07
NZO/HlLtJ f 5.66 1.5646   5 0.69971 0.2764 3.5, 7.7 1.99
NZO/HlLtJ m 2.9 0.0   1   0.0 0.0 2.9, 2.9 -0.01
PWK/PhJ f 3.025 0.80571   4 0.40285 0.2664 2.2, 4.1 -0.26
PWK/PhJ m 3.82 1.545   5 0.69094 0.4044 1.4, 5.1 0.77
WSB/EiJ f 2.5667 1.0504   3 0.60645 0.4092 1.5, 3.6 -0.66
WSB/EiJ m 2.04 0.61074   5 0.27313 0.2994 1.3, 2.7 -0.74


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2.24 0.4387875611 3.1189971094 1.3610028906
129S1/SvImJ m 1.7 0.6937840511 3.0898164612 0.3101835388
A/J f 3.9 0.4905794072 4.8827486443 2.9172513557
A/J m 5.42 0.4387875611 6.2989971094 4.5410028906
C57BL/6J f 3.7 0.5664723056 4.8347803887 2.5652196113
C57BL/6J m 2.825 0.4905794072 3.8077486443 1.8422513557
CAST/EiJ f 1.62 0.4387875611 2.4989971094 0.7410028906
CAST/EiJ m 1.6 0.6937840511 2.9898164612 0.2101835388
DBA/2J f 3.78 0.4387875611 4.6589971094 2.9010028906
DBA/2J m 2.94 0.4387875611 3.8189971094 2.0610028906
NOD/ShiLtJ f 3.5 0.31026966 4.1215448167 2.8784551833
NOD/ShiLtJ m 3.0 0.4387875611 3.8789971094 2.1210028906
PWK/PhJ f 3.025 0.4905794072 4.0077486443 2.0422513557
PWK/PhJ m 3.82 0.4387875611 4.6989971094 2.9410028906
WSB/EiJ f 2.5666666667 0.5664723056 3.7014470554 1.431886278
WSB/EiJ m 2.04 0.4387875611 2.9189971094 1.1610028906


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.97 0.4104481798 2.7922265068 1.1477734932
A/J both 4.66 0.3290906709 5.319247832 4.000752168
C57BL/6J both 3.2625 0.3746862113 4.0130866753 2.5119133247
CAST/EiJ both 1.61 0.4104481798 2.4322265068 0.7877734932
DBA/2J both 3.36 0.31026966 3.9815448167 2.7384551833
NOD/ShiLtJ both 3.25 0.2687014076 3.7882736009 2.7117263991
PWK/PhJ both 3.4225 0.3290906709 4.081747832 2.763252168
WSB/EiJ both 2.3033333333 0.3582685434 3.0210314678 1.5856351989




  GWAS USING LINEAR MIXED MODELS