Project measure / variable:   Auwerx2   lactate_CD

ID, description, units MPD:114681   lactate_CD   plasma lactate amount   [mmol/L]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma lactate amount CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means2.7075   mmol/L 2.743   mmol/L
Median of the strain means2.8   mmol/L 2.64   mmol/L
SD of the strain means± 0.80327 ± 0.7781
Coefficient of variation (CV)0.2967 0.2837
Min–max range of strain means1.3   –   3.9143   mmol/L 1.6667   –   4.14   mmol/L
Mean sample size per strain4.4   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.001 0.001 0.0014 0.9702
strain 7 32.7701 4.6814 6.5922 < 0.0001
sex:strain 7 9.0112 1.2873 1.8127 0.1003
Residuals 63 44.7392 0.7101


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2.9 0.5244   5 0.23452 0.1808 2.4, 3.6 0.24
129S1/SvImJ m 2.64 0.37148   5 0.16613 0.1407 2.1, 3.1 -0.13
A/J f 2.94 0.27019   5 0.12083 0.0919 2.6, 3.2 0.29
A/J m 4.14 0.56833   5 0.25417 0.1373 3.3, 4.9 1.8
C57BL/6J f 3.64 1.0286   5 0.46 0.2826 2.5, 4.9 1.16
C57BL/6J m 2.84 0.53198   5 0.23791 0.1873 2.1, 3.4 0.12
CAST/EiJ f 1.9 0.0   1   0.0 0.0 1.9, 1.9 -1.01
CAST/EiJ m 1.6667 0.49329   3 0.2848 0.296 1.1, 2.0 -1.38
DBA/2J f 2.54 0.68044   5 0.3043 0.2679 1.9, 3.6 -0.21
DBA/2J m 2.06 0.70922   5 0.31718 0.3443 1.5, 3.2 -0.88
NOD/ShiLtJ f 3.9143 1.1524   7 0.43558 0.2944 2.9, 6.1 1.5
NOD/ShiLtJ m 3.32 1.1946   5 0.53423 0.3598 2.1, 4.9 0.74
NZO/HlLtJ f 2.8 1.3367   4 0.66833 0.4774 1.6, 4.4 0.12
NZO/HlLtJ m 3.36 0.85615   5 0.38288 0.2548 2.3, 4.6 0.79
PWK/PhJ f 1.3 0.43012   5 0.19235 0.3309 0.8, 1.9 -1.75
PWK/PhJ m 2.02 0.63797   5 0.28531 0.3158 1.3, 2.9 -0.93
WSB/EiJ f 2.4333 0.58595   3 0.3383 0.2408 2.0, 3.1 -0.34
WSB/EiJ m 2.64 1.3465   5 0.60216 0.51 1.7, 5.0 -0.13


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2.9 0.3768677849 3.6531101737 2.1468898263
129S1/SvImJ m 2.64 0.3768677849 3.3931101737 1.8868898263
A/J f 2.94 0.3768677849 3.6931101737 2.1868898263
A/J m 4.14 0.3768677849 4.8931101737 3.3868898263
C57BL/6J f 3.64 0.3768677849 4.3931101737 2.8868898263
C57BL/6J m 2.84 0.3768677849 3.5931101737 2.0868898263
DBA/2J f 2.54 0.3768677849 3.2931101737 1.7868898263
DBA/2J m 2.06 0.3768677849 2.8131101737 1.3068898263
NOD/ShiLtJ f 3.9142857143 0.3185114119 4.5507799819 3.2777914467
NOD/ShiLtJ m 3.32 0.3768677849 4.0731101737 2.5668898263
NZO/HlLtJ f 2.8 0.4213509928 3.6420027715 1.9579972285
NZO/HlLtJ m 3.36 0.3768677849 4.1131101737 2.6068898263
PWK/PhJ f 1.3 0.3768677849 2.0531101737 0.5468898263
PWK/PhJ m 2.02 0.3768677849 2.7731101737 1.2668898263
WSB/EiJ f 2.4333333333 0.4865342182 3.4055943869 1.4610722798
WSB/EiJ m 2.64 0.3768677849 3.3931101737 1.8868898263


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 2.77 0.2664857663 3.3025293108 2.2374706892
A/J both 3.54 0.2664857663 4.0725293108 3.0074706892
C57BL/6J both 3.24 0.2664857663 3.7725293108 2.7074706892
DBA/2J both 2.3 0.2664857663 2.8325293108 1.7674706892
NOD/ShiLtJ both 3.6171428571 0.2467178787 4.1101691968 3.1241165175
NZO/HlLtJ both 3.08 0.2826508387 3.6448326303 2.5151673697
PWK/PhJ both 1.66 0.2664857663 2.1925293108 1.1274706892
WSB/EiJ both 2.5366666667 0.3077112578 3.1515785486 1.9217547848




  GWAS USING LINEAR MIXED MODELS