Project measure / variable:   Auwerx2   creatinine_HFD

ID, description, units MPD:114676   creatinine_HFD   plasma creatinine amount   [µmol/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
Ontology mappings

  STRAIN COMPARISON PLOT
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Auwerx2 - plasma creatinine amount HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means10.329   µmol/L 8.6694   µmol/L
Median of the strain means9.6   µmol/L 8.56   µmol/L
SD of the strain means± 1.884 ± 1.2502
Coefficient of variation (CV)0.1824 0.1442
Min–max range of strain means8.14   –   13.56   µmol/L 7.35   –   11.6   µmol/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 97.3972 97.3972 12.4644 0.0008
strain 7 127.5628 18.2233 2.3321 0.0367
sex:strain 7 51.5896 7.3699 0.9432 0.4812
Residuals 56 437.5853 7.814


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 9.3 2.3696   5 1.0597 0.2548 6.0, 12.0 -0.55
129S1/SvImJ m 8.2 4.8083   2   3.4 0.5864 4.8, 11.6 -0.38
A/J f 9.6 3.6341   4 1.817 0.3786 5.7, 13.6 -0.39
A/J m 8.62 2.4854   5 1.1115 0.2883 6.4, 11.8 -0.04
C57BL/6J f 9.1667 2.2143   3 1.2785 0.2416 7.6, 11.7 -0.62
C57BL/6J m 7.375 3.1117   4 1.5558 0.4219 2.8, 9.7 -1.04
CAST/EiJ f 8.14 1.5453   5 0.69109 0.1898 6.2, 9.7 -1.16
CAST/EiJ m 7.35 0.6364   2   0.45 0.0866 6.9, 7.8 -1.06
DBA/2J f 12.52 1.5007   5 0.67112 0.1199 11.0, 14.8 1.16
DBA/2J m 8.38 3.1276   5 1.3987 0.3732 3.5, 12.2 -0.23
NOD/ShiLtJ f 13.56 3.0137   10 0.95303 0.2223 7.8, 17.2 1.72
NOD/ShiLtJ m 8.96 1.7573   5 0.78588 0.1961 7.0, 11.4 0.23
NZO/HlLtJ f 11.48 4.8777   5 2.1814 0.4249 5.0, 17.8 0.61
NZO/HlLtJ m 11.6 0.0   1   0.0 0.0 11.6, 11.6 2.34
PWK/PhJ f 10.825 0.71822   4 0.35911 0.0663 10.1, 11.7 0.26
PWK/PhJ m 8.56 1.9907   5 0.89028 0.2326 5.5, 10.2 -0.09
WSB/EiJ f 8.3667 1.5567   3 0.89876 0.1861 6.9, 10.0 -1.04
WSB/EiJ m 8.98 5.3476   5 2.3915 0.5955 0.5, 14.9 0.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 9.3 1.2501218988 11.8042950912 6.7957049088
129S1/SvImJ m 8.2 1.9766162766 12.1596382107 4.2403617893
A/J f 9.6 1.397678773 12.3998870299 6.8001129701
A/J m 8.62 1.2501218988 11.1242950912 6.1157049088
C57BL/6J f 9.1666666667 1.6139004316 12.3996977274 5.9336356059
C57BL/6J m 7.375 1.397678773 10.1748870299 4.5751129701
CAST/EiJ f 8.14 1.2501218988 10.6442950912 5.6357049088
CAST/EiJ m 7.35 1.9766162766 11.3096382107 3.3903617893
DBA/2J f 12.52 1.2501218988 15.0242950912 10.0157049088
DBA/2J m 8.38 1.2501218988 10.8842950912 5.8757049088
NOD/ShiLtJ f 13.56 0.883969672 15.3308040411 11.7891959589
NOD/ShiLtJ m 8.96 1.2501218988 11.4642950912 6.4557049088
PWK/PhJ f 10.825 1.397678773 13.6248870299 8.0251129701
PWK/PhJ m 8.56 1.2501218988 11.0642950912 6.0557049088
WSB/EiJ f 8.3666666667 1.6139004316 11.5996977274 5.1336356059
WSB/EiJ m 8.98 1.2501218988 11.4842950912 6.4757049088


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 8.75 1.1693819593 11.0925535567 6.4074464433
A/J both 9.11 0.9375914241 10.9882213184 7.2317786816
C57BL/6J both 8.2708333333 1.0674947957 10.4092823753 6.1323842914
CAST/EiJ both 7.745 1.1693819593 10.0875535567 5.4024464433
DBA/2J both 10.45 0.883969672 12.2208040411 8.6791959589
NOD/ShiLtJ both 11.26 0.7655401921 12.7935612847 9.7264387153
PWK/PhJ both 9.6925 0.9375914241 11.5707213184 7.8142786816
WSB/EiJ both 8.6733333333 1.0207202561 10.718081713 6.6285849537




  GWAS USING LINEAR MIXED MODELS