Project measure / variable:   Auwerx2   ASAT_HFD

ID, description, units MPD:114674   ASAT_HFD   plasma aspartate transaminase amount (ASAT)   [U/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma aspartate transaminase amount (ASAT) HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means165.6   U/L 132.0   U/L
Median of the strain means142.7   U/L 103.5   U/L
SD of the strain means± 74.69 ± 83.22
Coefficient of variation (CV)0.4511 0.6303
Min–max range of strain means77.4   –   291.0   U/L 56.6   –   330.6   U/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7427.6442 7427.6442 0.7971 0.3758
strain 7 213217.6857 30459.6694 3.2689 0.0056
sex:strain 7 184231.5117 26318.7874 2.8245 0.0136
Residuals 56 521804.0333 9317.9292


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 134.4 55.19   5 24.683 0.4107 55.0, 194.0 -0.42
129S1/SvImJ m 103.5 34.648   2   24.5 0.3348 79.0, 128.0 -0.34
A/J f 115.5 27.982   4 13.991 0.2423 90.0, 144.0 -0.67
A/J m 94.6 17.329   5 7.7498 0.1832 76.0, 115.0 -0.45
C57BL/6J f 102.3 36.856   3 21.279 0.3602 74.0, 144.0 -0.85
C57BL/6J m 88.5 32.848   4 16.424 0.3712 50.0, 129.0 -0.52
CAST/EiJ f 177.4 32.028   5 14.323 0.1805 140.0, 211.0 0.16
CAST/EiJ m 150.5 47.376   2   33.5 0.3148 117.0, 184.0 0.22
DBA/2J f 77.4 28.902   5 12.925 0.3734 45.0, 121.0 -1.18
DBA/2J m 63.2 21.335   5 9.5415 0.3376 39.0, 90.0 -0.83
NOD/ShiLtJ f 170.1 83.03   10 26.255 0.4881 96.0, 329.0 0.06
NOD/ShiLtJ m 164.8 123.6   5 55.27 0.7499 79.0, 383.0 0.39
NZO/HlLtJ f 279.4 114.7   5 51.3 0.4105 139.0, 386.0 1.52
NZO/HlLtJ m 136.0 0.0   1   0.0 0.0 136.0, 136.0 0.05
PWK/PhJ f 291.0 54.88   4 27.438 0.1886 244.0, 370.0 1.68
PWK/PhJ m 56.6 10.065   5 4.5011 0.1778 42.0, 67.0 -0.91
WSB/EiJ f 142.7 70.15   3 40.502 0.4917 70.0, 210.0 -0.31
WSB/EiJ m 330.6 293.7   5 131.3 0.8883 159.0, 853.0 2.39


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 134.4 43.1692695483 220.8784385621 47.9215614379
129S1/SvImJ m 103.5 68.2566083492 240.2344171755 -33.2344171755
A/J f 115.5 48.2647106245 212.1858336064 18.8141663936
A/J m 94.6 43.1692695483 181.0784385621 8.1215614379
C57BL/6J f 102.3333333333 55.7312873428 213.9765174523 -9.3098507856
C57BL/6J m 88.5 48.2647106245 185.1858336064 -8.1858336064
CAST/EiJ f 177.4 43.1692695483 263.8784385621 90.9215614379
CAST/EiJ m 150.5 68.2566083492 287.2344171755 13.7655828245
DBA/2J f 77.4 43.1692695483 163.8784385621 -9.0784385621
DBA/2J m 63.2 43.1692695483 149.6784385621 -23.2784385621
NOD/ShiLtJ f 170.1 30.5252832365 231.2494903337 108.9505096663
NOD/ShiLtJ m 164.8 43.1692695483 251.2784385621 78.3215614379
PWK/PhJ f 291.0 48.2647106245 387.6858336064 194.3141663936
PWK/PhJ m 56.6 43.1692695483 143.0784385621 -29.8784385621
WSB/EiJ f 142.6666666667 55.7312873428 254.3098507856 31.0234825477
WSB/EiJ m 330.6 43.1692695483 417.0784385621 244.1215614379


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 118.95 40.3811540718 199.8431721106 38.0568278894
A/J both 105.05 32.3769521612 169.9088289215 40.1911710785
C57BL/6J both 95.4166666667 36.8627816387 169.2616918552 21.5716414781
CAST/EiJ both 163.95 40.3811540718 244.8431721106 83.0568278894
DBA/2J both 70.3 30.5252832365 131.4494903337 9.1505096663
NOD/ShiLtJ both 167.45 26.4356707405 220.4070120574 114.4929879426
PWK/PhJ both 173.8 32.3769521612 238.6588289215 108.9411710785
WSB/EiJ both 236.6333333333 35.2475609873 307.2426827432 166.0239839234




  GWAS USING LINEAR MIXED MODELS