Project measure / variable:   Auwerx2   ASAT_CD

ID, description, units MPD:114673   ASAT_CD   plasma aspartate transaminase amount (ASAT)   [U/L]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma aspartate transaminase amount (ASAT) CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means188.3   U/L 120.1   U/L
Median of the strain means101.0   U/L 85.6   U/L
SD of the strain means± 179.1 ± 73.63
Coefficient of variation (CV)0.9515 0.6129
Min–max range of strain means80.8   –   640.5   U/L 55.8   –   258.3   U/L
Mean sample size per strain4.3   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 64237.9631 64237.9631 5.7267 0.0198
strain 7 465900.7694 66557.2528 5.9335 < 0.0001
sex:strain 7 243101.8643 34728.8378 3.096 0.0073
Residuals 62 695471.5571 11217.2832


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 100.0 42.19   5 18.868 0.4219 54.0, 150.0 -0.49
129S1/SvImJ m 58.2 10.426   5 4.6626 0.1791 46.0, 71.0 -0.84
A/J f 173.2 59.8   5 26.744 0.3453 123.0, 271.0 -0.08
A/J m 79.0 28.697   5 12.834 0.3632 28.0, 97.0 -0.56
C57BL/6J f 80.8 31.26   5 13.98 0.3869 47.0, 127.0 -0.6
C57BL/6J m 55.8 27.105   5 12.122 0.4858 30.0, 89.0 -0.87
CAST/EiJ f 101.0 0.0   1   0.0 0.0 101.0, 101.0 -0.49
CAST/EiJ m 258.3 186.8   3 107.8 0.723 133.0, 473.0 1.88
DBA/2J f 93.2 18.754   5 8.3869 0.2012 64.0, 111.0 -0.53
DBA/2J m 109.6 53.41   5 23.886 0.4873 51.0, 158.0 -0.14
NOD/ShiLtJ f 153.1 57.05   7 21.562 0.3725 95.0, 226.0 -0.2
NOD/ShiLtJ m 57.6 22.634   5 10.122 0.393 40.0, 96.0 -0.85
NZO/HlLtJ f 261.5 287.0   4 143.5 1.0974 46.0, 678.0 0.41
NZO/HlLtJ m 185.0 32.917   5 14.721 0.1779 160.0, 223.0 0.88
PWK/PhJ f 91.2 27.499   5 12.298 0.3015 59.0, 129.0 -0.54
PWK/PhJ m 85.6 67.25   5 30.074 0.7856 45.0, 205.0 -0.47
WSB/EiJ f 640.5 543.8   2   384.5 0.849 256.0, 1025.0 2.52
WSB/EiJ m 192.2 123.4   5 55.17 0.6418 108.0, 394.0 0.98


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 100.0 47.36514157 194.6815688987 5.3184311013
129S1/SvImJ m 58.2 47.36514157 152.8815688987 -36.4815688987
A/J f 173.2 47.36514157 267.8815688987 78.5184311013
A/J m 79.0 47.36514157 173.6815688987 -15.6815688987
C57BL/6J f 80.8 47.36514157 175.4815688987 -13.8815688987
C57BL/6J m 55.8 47.36514157 150.4815688987 -38.8815688987
DBA/2J f 93.2 47.36514157 187.8815688987 -1.4815688987
DBA/2J m 109.6 47.36514157 204.2815688987 14.9184311013
NOD/ShiLtJ f 153.1428571429 40.0308509237 233.1633879419 73.1223263438
NOD/ShiLtJ m 57.6 47.36514157 152.2815688987 -37.0815688987
NZO/HlLtJ f 261.5 52.9558381572 367.3572121369 155.6427878631
NZO/HlLtJ m 185.0 47.36514157 279.6815688987 90.3184311013
PWK/PhJ f 91.2 47.36514157 185.8815688987 -3.4815688987
PWK/PhJ m 85.6 47.36514157 180.2815688987 -9.0815688987
WSB/EiJ f 640.5 74.8908645287 790.204705079 490.795294921
WSB/EiJ m 192.2 47.36514157 286.8815688987 97.5184311013


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 79.1 33.492212796 146.0499794216 12.1500205784
A/J both 126.1 33.492212796 193.0499794216 59.1500205784
C57BL/6J both 68.3 33.492212796 135.2499794216 1.3500205784
DBA/2J both 101.4 33.492212796 168.3499794216 34.4500205784
NOD/ShiLtJ both 105.3714285714 31.0077637924 167.3550651993 43.3877919435
NZO/HlLtJ both 223.25 35.5238561775 294.261176674 152.238823326
PWK/PhJ both 88.4 33.492212796 155.3499794216 21.4500205784
WSB/EiJ both 416.35 44.3060329577 504.9164979152 327.7835020848




  GWAS USING LINEAR MIXED MODELS