Project measure / variable:   Auwerx2   ALAT_CD

ID, description, units MPD:114671   ALAT_CD   plasma alanine transaminase amount (ALAT)   [U/L]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma alanine transaminase amount (ALAT) CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means55.2   U/L 55.26   U/L
Median of the strain means45.0   U/L 36.6   U/L
SD of the strain means± 33.61 ± 41.767
Coefficient of variation (CV)0.6089 0.7558
Min–max range of strain means30.4   –   140.0   U/L 28.2   –   155.0   U/L
Mean sample size per strain4.3   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 703.0778 703.0778 0.4141 0.5223
strain 7 81272.5082 11610.3583 6.8381 < 0.0001
sex:strain 7 10624.9089 1517.8441 0.894 0.5169
Residuals 62 105268.8 1697.8839


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 50.2 59.18   5 26.466 1.1789 16.0, 155.0 -0.15
129S1/SvImJ m 28.2 3.7014   5 1.6553 0.1313 24.0, 33.0 -0.65
A/J f 69.2 27.545   5 12.318 0.398 35.0, 103.0 0.42
A/J m 29.2 9.1214   5 4.0792 0.3124 17.0, 41.0 -0.62
C57BL/6J f 30.4 4.98   5 2.2271 0.1638 25.0, 35.0 -0.74
C57BL/6J m 45.0 12.826   5 5.7359 0.285 33.0, 61.0 -0.25
CAST/EiJ f 45.0 0.0   1   0.0 0.0 45.0, 45.0 -0.3
CAST/EiJ m 54.33 13.577   3 7.8387 0.2499 46.0, 70.0 -0.02
DBA/2J f 36.6 5.8566   5 2.6192 0.16 31.0, 44.0 -0.55
DBA/2J m 36.6 13.39   5 5.9883 0.3659 23.0, 59.0 -0.45
NOD/ShiLtJ f 39.0 13.638   7 5.1547 0.3497 30.0, 69.0 -0.48
NOD/ShiLtJ m 30.2 3.7683   5 1.6852 0.1248 24.0, 34.0 -0.6
NZO/HlLtJ f 41.0 28.96   4 14.48 0.7063 22.0, 84.0 -0.42
NZO/HlLtJ m 32.2 6.8337   5 3.0561 0.2122 23.0, 41.0 -0.55
PWK/PhJ f 45.4 8.3546   5 3.7363 0.184 36.0, 58.0 -0.29
PWK/PhJ m 86.6 101.7   5 45.48 1.1743 25.0, 264.0 0.75
WSB/EiJ f 140.0 120.2   2   85.0 0.8586 55.0, 225.0 2.52
WSB/EiJ m 155.0 81.01   5 36.23 0.5227 95.0, 280.0 2.39


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 50.2 18.42760902 87.036265558 13.363734442
129S1/SvImJ m 28.2 18.42760902 65.036265558 -8.636265558
A/J f 69.2 18.42760902 106.036265558 32.363734442
A/J m 29.2 18.42760902 66.036265558 -7.636265558
C57BL/6J f 30.4 18.42760902 67.236265558 -6.436265558
C57BL/6J m 45.0 18.42760902 81.836265558 8.163734442
DBA/2J f 36.6 18.42760902 73.436265558 -0.236265558
DBA/2J m 36.6 18.42760902 73.436265558 -0.236265558
NOD/ShiLtJ f 39.0 15.5741721677 70.1323265646 7.8676734354
NOD/ShiLtJ m 30.2 18.42760902 67.036265558 -6.636265558
NZO/HlLtJ f 41.0 20.6026932157 82.1841969124 -0.1841969124
NZO/HlLtJ m 32.2 18.42760902 69.036265558 -4.636265558
PWK/PhJ f 45.4 18.42760902 82.236265558 8.563734442
PWK/PhJ m 86.6 18.42760902 123.436265558 49.763734442
WSB/EiJ f 140.0 29.1366081671 198.243249829 81.756750171
WSB/EiJ m 155.0 18.42760902 191.836265558 118.163734442


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 39.2 13.0302872991 65.2471731696 13.1528268304
A/J both 49.2 13.0302872991 75.2471731696 23.1528268304
C57BL/6J both 37.7 13.0302872991 63.7471731696 11.6528268304
DBA/2J both 36.6 13.0302872991 62.6471731696 10.5528268304
NOD/ShiLtJ both 34.6 12.0637018873 58.7149964627 10.4850035373
NZO/HlLtJ both 36.6 13.820706765 64.2271991685 8.9728008315
PWK/PhJ both 66.0 13.0302872991 92.0471731696 39.9528268304
WSB/EiJ both 147.5 17.2374498526 181.9571712815 113.0428287185




  GWAS USING LINEAR MIXED MODELS