Project measure / variable:   Auwerx2   ogtt_ins_t30_CD

ID, description, units MPD:114605   ogtt_ins_t30_CD   insulin, glucose tolerance test (20% glucose oral gavage, overnight fast), after 30 min   [µg/L]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Auwerx2 - insulin, glucose tolerance test (20% glucose oral gavage, overnight fast), after 30 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means0.39976   µg/L 0.57678   µg/L
Median of the strain means0.35255   µg/L 0.56355   µg/L
SD of the strain means± 0.18531 ± 0.30938
Coefficient of variation (CV)0.4636 0.5364
Min–max range of strain means0.1505   –   0.72321   µg/L 0.16175   –   1.1561   µg/L
Mean sample size per strain4.1   mice 4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.4189 0.4189 2.8405 0.0981
strain 6 3.4614 0.5769 3.9115 0.0028
sex:strain 6 0.7919 0.132 0.8949 0.506
Residuals 50 7.3743 0.1475


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.2394 0.11328   5 0.05066 0.4732 0.138, 0.43 -0.87
129S1/SvImJ m 0.4844 0.20091   5 0.08985 0.4148 0.324, 0.8025 -0.3
A/J f 0.3179 0.06298   5 0.02817 0.1981 0.249, 0.395 -0.44
A/J m 0.2442 0.04157   5 0.01859 0.1702 0.178, 0.2835 -1.07
C57BL/6J f 0.3306 0.0486   5 0.02174 0.147 0.284, 0.3985 -0.37
C57BL/6J m 0.5511 0.17408   5 0.07785 0.3159 0.362, 0.768 -0.08
CAST/EiJ f 0.557 0.0   1   0.0 0.0 0.557, 0.557 0.85
CAST/EiJ m 0.6965 0.20344   3 0.11746 0.2921 0.544, 0.9275 0.39
DBA/2J f 0.505 0.06836   4 0.03418 0.1354 0.43, 0.572 0.57
DBA/2J m 1.1561 0.73975   5 0.33083 0.6399 0.5625, 2.4405 1.87
NOD/ShiLtJ f 0.72321 0.7116   7 0.26896 0.9839 0.127, 2.2395 1.75
NOD/ShiLtJ m 0.7442 0.65877   5 0.29461 0.8852 0.322, 1.897 0.54
PWK/PhJ f 0.3745 0.00793725   3 0.00458258 0.0212 0.3655, 0.3805 -0.14
PWK/PhJ m 0.576 0.10974   3 0.06336 0.1905 0.458, 0.675 0.0
WSB/EiJ f 0.1505 0.03596   3 0.02076 0.2389 0.1125, 0.184 -1.35
WSB/EiJ m 0.16175 0.03747   4 0.01873 0.2316 0.1135, 0.2045 -1.34


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.2394 0.171747582 0.5843651708 -0.1055651708
129S1/SvImJ m 0.4844 0.171747582 0.8293651708 0.1394348292
A/J f 0.3179 0.171747582 0.6628651708 -0.0270651708
A/J m 0.2442 0.171747582 0.5891651708 -0.1007651708
C57BL/6J f 0.3306 0.171747582 0.6755651708 -0.0143651708
C57BL/6J m 0.5511 0.171747582 0.8960651708 0.2061348292
DBA/2J f 0.505 0.1920196341 0.8906827858 0.1193172142
DBA/2J m 1.1561 0.171747582 1.5010651708 0.8111348292
NOD/ShiLtJ f 0.7232142857 0.1451531996 1.0147630675 0.4316655039
NOD/ShiLtJ m 0.7442 0.171747582 1.0891651708 0.3992348292
PWK/PhJ f 0.3745 0.2217251749 0.8198481205 -0.0708481205
PWK/PhJ m 0.576 0.2217251749 1.0213481205 0.1306518795
WSB/EiJ f 0.1505 0.2217251749 0.5958481205 -0.2948481205
WSB/EiJ m 0.16175 0.1920196341 0.5474327858 -0.2239327858


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.3619 0.1214438799 0.6058272115 0.1179727885
A/J both 0.28105 0.1214438799 0.5249772115 0.0371227885
C57BL/6J both 0.44085 0.1214438799 0.6847772115 0.1969227885
DBA/2J both 0.83055 0.1288106865 1.0892738781 0.5718261219
NOD/ShiLtJ both 0.7337071429 0.112435185 0.9595398582 0.5078744276
PWK/PhJ both 0.47525 0.1567833747 0.790158676 0.160341324
WSB/EiJ both 0.156125 0.1466574181 0.4506950934 -0.1384450934




  GWAS USING LINEAR MIXED MODELS