Project measure / variable:   Auwerx2   ogtt_ins_t0_HFD

ID, description, units MPD:114602   ogtt_ins_t0_HFD   insulin baseline, glucose tolerance test (pregavage, overnight fast)   [µg/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 16wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Auwerx2 - insulin baseline, glucose tolerance test (pregavage, overnight fast) HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means1.2951   µg/L 0.7702   µg/L
Median of the strain means0.431   µg/L 0.72538   µg/L
SD of the strain means± 2.0886 ± 0.51585
Coefficient of variation (CV)1.6127 0.6698
Min–max range of strain means0.0447   –   6.5401   µg/L 0.1945   –   1.735   µg/L
Mean sample size per strain4.4   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.052 0.052 0.4402 0.51
strain 7 17.793 2.5419 21.509 < 0.0001
sex:strain 7 3.4163 0.488 4.1298 0.0011
Residuals 52 6.1452 0.1182


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.0447 0.01871   5 0.00836899 0.4186 0.0285, 0.077 -0.6
129S1/SvImJ m 0.23 0.07354   2   0.052 0.3197 0.178, 0.282 -1.05
A/J f 0.205 0.05683   4 0.02842 0.2772 0.163, 0.2845 -0.52
A/J m 0.3541 0.15482   5 0.06924 0.4372 0.204, 0.607 -0.81
C57BL/6J f 0.24983 0.04855   3 0.02803 0.1943 0.197, 0.2925 -0.5
C57BL/6J m 0.72538 0.47218   4 0.23609 0.6509 0.0445, 1.1095 -0.09
CAST/EiJ f 0.1491 0.04492   5 0.02009 0.3013 0.083, 0.2025 -0.55
CAST/EiJ m 0.559 0.32103   2   0.227 0.5743 0.332, 0.786 -0.41
DBA/2J f 1.1161 0.68038   5 0.30427 0.6096 0.439, 2.2365 -0.09
DBA/2J m 1.1538 0.57401   5 0.2567 0.4975 0.6915, 2.14 0.74
NOD/ShiLtJ f 0.62442 0.2422   6 0.09888 0.3879 0.398, 1.0545 -0.32
NOD/ShiLtJ m 0.7542 0.43081   5 0.19266 0.5712 0.498, 1.513 -0.03
NZO/HlLtJ f 6.5401 2.6048   5 1.1649 0.3983 4.683, 11.12 2.51
NZO/HlLtJ m 1.735 0.0   1   0.0 0.0 1.735, 1.735 1.87
PWK/PhJ f 2.2959 0.3233   4 0.16165 0.1408 1.9865, 2.7095 0.48
PWK/PhJ m 1.2258 0.30847   5 0.13795 0.2516 0.981, 1.6565 0.88
WSB/EiJ f 0.431 0.41153   3 0.2376 0.9548 0.155, 0.904 -0.41
WSB/EiJ m 0.1945 0.04977   5 0.02226 0.2559 0.1385, 0.272 -1.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.0447 0.1537374579 0.3531967787 -0.2637967787
129S1/SvImJ m 0.23 0.2430802643 0.7177762358 -0.2577762358
A/J f 0.205 0.1718837033 0.549909884 -0.139909884
A/J m 0.3541 0.1537374579 0.6625967787 0.0456032213
C57BL/6J f 0.2498333333 0.1984742047 0.6481009621 -0.1484342954
C57BL/6J m 0.725375 0.1718837033 1.070284884 0.380465116
CAST/EiJ f 0.1491 0.1537374579 0.4575967787 -0.1593967787
CAST/EiJ m 0.559 0.2430802643 1.0467762358 0.0712237642
DBA/2J f 1.1161 0.1537374579 1.4245967787 0.8076032213
DBA/2J m 1.1538 0.1537374579 1.4622967787 0.8453032213
NOD/ShiLtJ f 0.6244166667 0.140342456 0.9060344077 0.3427989256
NOD/ShiLtJ m 0.7542 0.1537374579 1.0626967787 0.4457032213
PWK/PhJ f 2.295875 0.1718837033 2.640784884 1.950965116
PWK/PhJ m 1.2258 0.1537374579 1.5342967787 0.9173032213
WSB/EiJ f 0.431 0.1984742047 0.8292676288 0.0327323712
WSB/EiJ m 0.1945 0.1537374579 0.5029967787 -0.1139967787


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.13735 0.1438082237 0.4259223127 -0.1512223127
A/J both 0.27955 0.1153030934 0.510922584 0.048177416
C57BL/6J both 0.4876041667 0.1312783468 0.7510334419 0.2241748914
CAST/EiJ both 0.35405 0.1438082237 0.6426223127 0.0654776873
DBA/2J both 1.13495 0.108708799 1.3530901642 0.9168098358
NOD/ShiLtJ both 0.6893083333 0.104080751 0.8981616398 0.4804550268
PWK/PhJ both 1.7608375 0.1153030934 1.992210084 1.529464916
WSB/EiJ both 0.31275 0.1255261087 0.564636565 0.060863435




  GWAS USING LINEAR MIXED MODELS