Project measure / variable:   Auwerx2   ogtt_ins_t0_CD

ID, description, units MPD:114601   ogtt_ins_t0_CD   insulin baseline, glucose tolerance test (pregavage, overnight fast)   [µg/L]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 16wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Auwerx2 - insulin baseline, glucose tolerance test (pregavage, overnight fast) CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means0.50611   µg/L 0.49757   µg/L
Median of the strain means0.20775   µg/L 0.3106   µg/L
SD of the strain means± 0.78097 ± 0.67092
Coefficient of variation (CV)1.5431 1.3484
Min–max range of strain means0.0617   –   2.5373   µg/L 0.14067   –   2.2611   µg/L
Mean sample size per strain4.3   mice 4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0804 0.0804 0.5806 0.449
strain 7 36.2987 5.1855 37.4419 < 0.0001
sex:strain 7 0.6987 0.0998 0.7207 0.6548
Residuals 61 8.4482 0.1385


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.0683 0.05841   5 0.02612 0.8551 -0.56
129S1/SvImJ m 0.2634 0.19874   5 0.08888 0.7545 0.143, 0.6165 -0.35
A/J f 0.2061 0.07844   5 0.03508 0.3806 0.1245, 0.324 -0.38
A/J m 0.1509 0.0446   5 0.01995 0.2956 0.11, 0.207 -0.52
C57BL/6J f 0.0617 0.06721   5 0.03006 1.0894 -0.57
C57BL/6J m 0.3163 0.27639   5 0.12361 0.8738 0.109, 0.7865 -0.27
CAST/EiJ f 0.477 0.0   1   0.0 0.0 0.477, 0.477 -0.04
CAST/EiJ m 0.14067 0.02844   3 0.01642 0.2022 0.1105, 0.167 -0.53
DBA/2J f 0.20775 0.12059   4 0.0603 0.5805 0.1255, 0.387 -0.38
DBA/2J m 0.3854 0.18397   5 0.08227 0.4773 0.1395, 0.59 -0.17
NOD/ShiLtJ f 0.5425 0.83344   7 0.31501 1.5363 0.036, 2.4025 0.05
NOD/ShiLtJ m 0.3106 0.42287   5 0.18911 1.3615 -0.28
NZO/HlLtJ f 2.5373 0.71682   4 0.35841 0.2825 1.7085, 3.451 2.6
NZO/HlLtJ m 2.2611 0.4979   5 0.22267 0.2202 1.6905, 2.9935 2.63
PWK/PhJ f 0.3447 0.13572   5 0.0607 0.3937 0.231, 0.5645 -0.21
PWK/PhJ m 0.4808 0.24681   5 0.11038 0.5133 0.1885, 0.779 -0.03
WSB/EiJ f 0.10967 0.02097   3 0.0121 0.1912 0.0855, 0.123 -0.51
WSB/EiJ m 0.169 0.04843   4 0.02422 0.2866 0.1295, 0.233 -0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.0683 0.1664303366 0.4010980263 -0.2644980263
129S1/SvImJ m 0.2634 0.1664303366 0.5961980263 -0.0693980263
A/J f 0.2061 0.1664303366 0.5388980263 -0.1266980263
A/J m 0.1509 0.1664303366 0.4836980263 -0.1818980263
C57BL/6J f 0.0617 0.1664303366 0.3944980263 -0.2710980263
C57BL/6J m 0.3163 0.1664303366 0.6490980263 -0.0164980263
DBA/2J f 0.20775 0.1860747731 0.5798295048 -0.1643295048
DBA/2J m 0.3854 0.1664303366 0.7181980263 0.0526019737
NOD/ShiLtJ f 0.5425 0.1406593071 0.8237656679 0.2612343321
NOD/ShiLtJ m 0.3106 0.1664303366 0.6433980263 -0.0221980263
NZO/HlLtJ f 2.53725 0.1860747731 2.9093295048 2.1651704952
NZO/HlLtJ m 2.2611 0.1664303366 2.5938980263 1.9283019737
PWK/PhJ f 0.3447 0.1664303366 0.6774980263 0.0119019737
PWK/PhJ m 0.4808 0.1664303366 0.8135980263 0.1480019737
WSB/EiJ f 0.1096666667 0.2148606406 0.5393070712 -0.3199737379
WSB/EiJ m 0.169 0.1860747731 0.5410795048 -0.2030795048


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.16585 0.1176840196 0.4011737412 -0.0694737412
A/J both 0.1785 0.1176840196 0.4138237412 -0.0568237412
C57BL/6J both 0.189 0.1176840196 0.4243237412 -0.0463237412
DBA/2J both 0.296575 0.1248227524 0.5461735197 0.0469764803
NOD/ShiLtJ both 0.42655 0.1089542308 0.6444174495 0.2086825505
NZO/HlLtJ both 2.399175 0.1248227524 2.6487735197 2.1495764803
PWK/PhJ both 0.41275 0.1176840196 0.6480737412 0.1774262588
WSB/EiJ both 0.1393333333 0.1421169554 0.4235137492 -0.1448470826




  GWAS USING LINEAR MIXED MODELS