Project measure / variable:   Auwerx2   ogtt_gluc_t180_CD

ID, description, units MPD:114599   ogtt_gluc_t180_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 180 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 180 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means87.37   mg/dL 111.2   mg/dL
Median of the strain means87.23   mg/dL 109.6   mg/dL
SD of the strain means± 10.868 ± 25.223
Coefficient of variation (CV)0.1244 0.2268
Min–max range of strain means71.33   –   102.2   mg/dL 68.2   –   149.0   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4220.1293 4220.1293 21.8378 < 0.0001
strain 6 13395.5563 2232.5927 11.5529 < 0.0001
sex:strain 6 3577.3205 596.2201 3.0852 0.0117
Residuals 52 10048.9333 193.2487


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 81.8 7.4967   5 3.3526 0.0916 69.0, 88.0 -0.51
129S1/SvImJ m 104.2 9.5237   5 4.2591 0.0914 93.0, 119.0 -0.28
A/J f 93.0 11.068   5 4.9497 0.119 77.0, 104.0 0.52
A/J m 120.6 10.644   5 4.7603 0.0883 109.0, 132.0 0.37
C57BL/6J f 102.2 9.7826   5 4.3749 0.0957 92.0, 117.0 1.36
C57BL/6J m 136.8 16.888   5 7.5525 0.1234 109.0, 153.0 1.01
CAST/EiJ f 77.0 0.0   1   0.0 0.0 77.0, 77.0 -0.95
CAST/EiJ m 149.0 32.909   3 19.0 0.2209 111.0, 168.0 1.5
DBA/2J f 99.2 21.913   5 9.8 0.2209 69.0, 127.0 1.09
DBA/2J m 91.8 7.8549   5 3.5128 0.0856 85.0, 104.0 -0.77
NOD/ShiLtJ f 71.33 14.224   3 8.2125 0.1994 55.0, 81.0 -1.48
NOD/ShiLtJ m 68.2 19.854   5 8.8792 0.2911 37.0, 88.0 -1.71
PWK/PhJ f 82.8 2.3875   5 1.0677 0.0288 81.0, 87.0 -0.42
PWK/PhJ m 108.8 8.0747   5 3.6111 0.0742 98.0, 117.0 -0.1
WSB/EiJ f 91.67 23.18   3 13.383 0.2529 65.0, 107.0 0.4
WSB/EiJ m 110.4 19.282   5 8.6232 0.1747 91.0, 137.0 -0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 81.8 6.2168917949 94.2751060577 69.3248939423
129S1/SvImJ m 104.2 6.2168917949 116.6751060577 91.7248939423
A/J f 93.0 6.2168917949 105.4751060577 80.5248939423
A/J m 120.6 6.2168917949 133.0751060577 108.1248939423
C57BL/6J f 102.2 6.2168917949 114.6751060577 89.7248939423
C57BL/6J m 136.8 6.2168917949 149.2751060577 124.3248939423
DBA/2J f 99.2 6.2168917949 111.6751060577 86.7248939423
DBA/2J m 91.8 6.2168917949 104.2751060577 79.3248939423
NOD/ShiLtJ f 71.3333333333 8.0259727956 87.4386260012 55.2280406655
NOD/ShiLtJ m 68.2 6.2168917949 80.6751060577 55.7248939423
PWK/PhJ f 82.8 6.2168917949 95.2751060577 70.3248939423
PWK/PhJ m 108.8 6.2168917949 121.2751060577 96.3248939423
WSB/EiJ f 91.6666666667 8.0259727956 107.7719593345 75.5613739988
WSB/EiJ m 110.4 6.2168917949 122.8751060577 97.9248939423


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 93.0 4.3960063461 101.8212320894 84.1787679106
A/J both 106.8 4.3960063461 115.6212320894 97.9787679106
C57BL/6J both 119.5 4.3960063461 128.3212320894 110.6787679106
DBA/2J both 95.5 4.3960063461 104.3212320894 86.6787679106
NOD/ShiLtJ both 69.7666666667 5.0760708945 79.9525481095 59.5807852239
PWK/PhJ both 95.8 4.3960063461 104.6212320894 86.9787679106
WSB/EiJ both 101.0333333333 5.0760708945 111.2192147761 90.8474518905




  GWAS USING LINEAR MIXED MODELS