Project measure / variable:   Auwerx2   ogtt_gluc_t150_HFD

ID, description, units MPD:114598   ogtt_gluc_t150_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 150 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 150 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means115.0   mg/dL 171.0   mg/dL
Median of the strain means108.6   mg/dL 168.6   mg/dL
SD of the strain means± 19.63 ± 40.188
Coefficient of variation (CV)0.1707 0.235
Min–max range of strain means89.0   –   151.9   mg/dL 109.4   –   222.2   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 45638.3381 45638.3381 12.7146 0.0008
strain 7 33040.8601 4720.1229 1.315 0.2604
sex:strain 7 33737.5046 4819.6435 1.3427 0.2479
Residuals 56 201008.95 3589.4455


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 89.0 17.762   5 7.9436 0.1996 69.0, 114.0 -1.32
129S1/SvImJ m 138.5 55.86   2   39.5 0.4033 99.0, 178.0 -0.81
A/J f 107.2 14.728   4 7.364 0.1373 96.0, 127.0 -0.4
A/J m 222.2 31.019   5 13.872 0.1396 195.0, 272.0 1.27
C57BL/6J f 136.0 21.517   3 12.423 0.1582 114.0, 157.0 1.07
C57BL/6J m 184.0 20.494   4 10.247 0.1114 163.0, 211.0 0.32
CAST/EiJ f 108.2 17.726   5 7.9272 0.1638 82.0, 125.0 -0.35
CAST/EiJ m 211.0 28.284   2   20.0 0.134 191.0, 231.0 1.0
DBA/2J f 111.6 2.7928   5 1.249 0.025 109.0, 115.0 -0.17
DBA/2J m 153.2 30.687   5 13.724 0.2003 124.0, 205.0 -0.44
NOD/ShiLtJ f 151.9 131.5   10 41.568 0.8654 72.0, 516.0 1.88
NOD/ShiLtJ m 145.6 33.828   5 15.128 0.2323 117.0, 202.0 -0.63
PWK/PhJ f 109.0 6.9761   4 3.4881 0.064 100.0, 115.0 -0.31
PWK/PhJ m 109.4 10.31   5 4.6109 0.0942 93.0, 121.0 -1.53
WSB/EiJ f 107.0 27.785   3 16.042 0.2597 89.0, 139.0 -0.41
WSB/EiJ m 204.2 73.96   5 33.076 0.3622 148.0, 292.0 0.83


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 89.0 26.7934526917 142.6737354306 35.3262645694
129S1/SvImJ m 138.5 42.3641684429 223.3656272449 53.6343727551
A/J f 107.25 29.9559907853 167.2590605145 47.2409394855
A/J m 222.2 26.7934526917 275.8737354306 168.5262645694
C57BL/6J f 136.0 34.5901986875 205.2924944838 66.7075055162
C57BL/6J m 184.0 29.9559907853 244.0090605145 123.9909394855
CAST/EiJ f 108.2 26.7934526917 161.8737354306 54.5262645694
CAST/EiJ m 211.0 42.3641684429 295.8656272449 126.1343727551
DBA/2J f 111.6 26.7934526917 165.2737354306 57.9262645694
DBA/2J m 153.2 26.7934526917 206.8737354306 99.5262645694
NOD/ShiLtJ f 151.9 18.9458320897 189.8530622946 113.9469377054
NOD/ShiLtJ m 145.6 26.7934526917 199.2737354306 91.9262645694
PWK/PhJ f 109.0 29.9559907853 169.0090605145 48.9909394855
PWK/PhJ m 109.4 26.7934526917 163.0737354306 55.7262645694
WSB/EiJ f 107.0 34.5901986875 176.2924944838 37.7075055162
WSB/EiJ m 204.2 26.7934526917 257.8737354306 150.5262645694


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 113.75 25.0629800453 163.9571821624 63.5428178376
A/J both 164.725 20.0950895188 204.9803015729 124.4696984271
C57BL/6J both 160.0 22.8792658818 205.8326770318 114.1673229682
CAST/EiJ both 159.6 25.0629800453 209.8071821624 109.3928178376
DBA/2J both 132.4 18.9458320897 170.3530622946 94.4469377054
NOD/ShiLtJ both 148.75 16.4075718855 181.6183160985 115.8816839015
PWK/PhJ both 109.2 20.0950895188 149.4553015729 68.9446984271
WSB/EiJ both 155.6 21.876762514 199.4244214647 111.7755785353




  GWAS USING LINEAR MIXED MODELS