Project measure / variable:   Auwerx2   ogtt_gluc_t150_CD

ID, description, units MPD:114597   ogtt_gluc_t150_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 150 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 150 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means87.83   mg/dL 119.3   mg/dL
Median of the strain means86.7   mg/dL 117.3   mg/dL
SD of the strain means± 26.433 ± 28.468
Coefficient of variation (CV)0.301 0.2386
Min–max range of strain means38.0   –   122.8   mg/dL 68.6   –   162.3   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5445.3848 5445.3848 14.0514 0.0004
strain 6 15995.426 2665.9043 6.8792 < 0.0001
sex:strain 6 10288.4407 1714.7401 4.4248 0.0011
Residuals 52 20151.7333 387.5333


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 86.4 11.718   5 5.2402 0.1356 73.0, 104.0 -0.05
129S1/SvImJ m 118.0 25.884   5 11.576 0.2194 103.0, 164.0 -0.05
A/J f 87.0 14.248   5 6.3718 0.1638 67.0, 102.0 -0.03
A/J m 130.6 18.036   5 8.066 0.1381 105.0, 152.0 0.4
C57BL/6J f 99.4 14.519   5 6.4931 0.1461 83.0, 123.0 0.44
C57BL/6J m 145.8 15.123   5 6.7631 0.1037 120.0, 160.0 0.93
CAST/EiJ f 38.0 0.0   1   0.0 0.0 38.0, 38.0 -1.89
CAST/EiJ m 162.3 34.078   3 19.675 0.2099 123.0, 183.0 1.51
DBA/2J f 122.8 30.037   5 13.433 0.2446 75.0, 151.0 1.32
DBA/2J m 100.0 7.3485   5 3.2863 0.0735 90.0, 109.0 -0.68
NOD/ShiLtJ f 73.33 19.655   3 11.348 0.268 51.0, 88.0 -0.55
NOD/ShiLtJ m 68.6 16.38   5 7.3253 0.2388 40.0, 81.0 -1.78
PWK/PhJ f 80.0 9.1924   5 4.111 0.1149 66.0, 89.0 -0.3
PWK/PhJ m 112.8 10.616   5 4.7476 0.0941 100.0, 126.0 -0.23
WSB/EiJ f 115.7 10.693   3 6.1734 0.0924 104.0, 125.0 1.05
WSB/EiJ m 116.6 39.885   5 17.837 0.3421 91.0, 185.0 -0.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 86.4 8.8037870639 104.0660911842 68.7339088158
129S1/SvImJ m 118.0 8.8037870639 135.6660911842 100.3339088158
A/J f 87.0 8.8037870639 104.6660911842 69.3339088158
A/J m 130.6 8.8037870639 148.2660911842 112.9339088158
C57BL/6J f 99.4 8.8037870639 117.0660911842 81.7339088158
C57BL/6J m 145.8 8.8037870639 163.4660911842 128.1339088158
DBA/2J f 122.8 8.8037870639 140.4660911842 105.1339088158
DBA/2J m 100.0 8.8037870639 117.6660911842 82.3339088158
NOD/ShiLtJ f 73.3333333333 11.3656402274 96.140158983 50.5265076836
NOD/ShiLtJ m 68.6 8.8037870639 86.2660911842 50.9339088158
PWK/PhJ f 80.0 8.8037870639 97.6660911842 62.3339088158
PWK/PhJ m 112.8 8.8037870639 130.4660911842 95.1339088158
WSB/EiJ f 115.6666666667 11.3656402274 138.4734923164 92.859841017
WSB/EiJ m 116.6 8.8037870639 134.2660911842 98.9339088158


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 102.2 6.225217533 114.6918128734 89.7081871266
A/J both 108.8 6.225217533 121.2918128734 96.3081871266
C57BL/6J both 122.6 6.225217533 135.0918128734 110.1081871266
DBA/2J both 111.4 6.225217533 123.8918128734 98.9081871266
NOD/ShiLtJ both 70.9666666667 7.1882620369 85.390969717 56.5423636164
PWK/PhJ both 96.4 6.225217533 108.8918128734 83.9081871266
WSB/EiJ both 116.1333333333 7.1882620369 130.5576363836 101.709030283




  GWAS USING LINEAR MIXED MODELS