Project measure / variable:   Auwerx2   ogtt_gluc_t120_HFD

ID, description, units MPD:114596   ogtt_gluc_t120_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 120 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 120 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means132.0   mg/dL 203.5   mg/dL
Median of the strain means124.8   mg/dL 207.1   mg/dL
SD of the strain means± 29.032 ± 54.96
Coefficient of variation (CV)0.22 0.2701
Min–max range of strain means105.8   –   186.9   mg/dL 111.6   –   264.0   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 72503.0773 72503.0773 15.3263 0.0002
strain 7 68702.2174 9814.6025 2.0747 0.0614
sex:strain 7 69235.1331 9890.7333 2.0908 0.0595
Residuals 56 264915.5167 4730.6342


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 105.8 17.398   5 7.7807 0.1644 89.0, 133.0 -0.9
129S1/SvImJ m 172.5 70.0   2   49.5 0.4058 123.0, 222.0 -0.56
A/J f 112.5 9.3274   4 4.6637 0.0829 103.0, 121.0 -0.67
A/J m 264.0 49.915   5 22.323 0.1891 212.0, 318.0 1.1
C57BL/6J f 164.7 10.263   3 5.9255 0.0623 156.0, 176.0 1.13
C57BL/6J m 245.0 32.537   4 16.269 0.1328 197.0, 267.0 0.76
CAST/EiJ f 107.4 22.233   5 9.9428 0.207 72.0, 129.0 -0.85
CAST/EiJ m 237.5 34.648   2   24.5 0.1459 213.0, 262.0 0.62
DBA/2J f 128.8 20.204   5 9.0355 0.1569 105.0, 151.0 -0.11
DBA/2J m 176.6 37.912   5 16.955 0.2147 149.0, 242.0 -0.49
NOD/ShiLtJ f 186.9 140.9   10 44.569 0.7541 83.0, 553.0 1.89
NOD/ShiLtJ m 163.6 58.04   5 25.957 0.3548 121.0, 261.0 -0.73
PWK/PhJ f 120.8 8.5781   4 4.289 0.071 113.0, 133.0 -0.39
PWK/PhJ m 111.6 15.192   5 6.7941 0.1361 89.0, 128.0 -1.67
WSB/EiJ f 129.0 44.508   3 25.697 0.345 85.0, 174.0 -0.1
WSB/EiJ m 257.2 96.53   5 43.171 0.3753 177.0, 382.0 0.98


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 105.8 30.7591749766 167.4180317912 44.1819682088
129S1/SvImJ m 172.5 48.6345259368 269.9266626984 75.0733373016
A/J f 112.5 34.3898030897 181.3910538624 43.6089461376
A/J m 264.0 30.7591749766 325.6180317912 202.3819682088
C57BL/6J f 164.6666666667 39.7099241424 244.2152036511 85.1181296822
C57BL/6J m 245.0 34.3898030897 313.8910538624 176.1089461376
CAST/EiJ f 107.4 30.7591749766 169.0180317912 45.7819682088
CAST/EiJ m 237.5 48.6345259368 334.9266626984 140.0733373016
DBA/2J f 128.8 30.7591749766 190.4180317912 67.1819682088
DBA/2J m 176.6 30.7591749766 238.2180317912 114.9819682088
NOD/ShiLtJ f 186.9 21.7500212096 230.4705281229 143.3294718771
NOD/ShiLtJ m 163.6 30.7591749766 225.2180317912 101.9819682088
PWK/PhJ f 120.75 34.3898030897 189.6410538624 51.8589461376
PWK/PhJ m 111.6 30.7591749766 173.2180317912 49.9819682088
WSB/EiJ f 129.0 39.7099241424 208.5485369845 49.4514630155
WSB/EiJ m 257.2 30.7591749766 318.8180317912 195.5819682088


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 139.15 28.7725735655 196.7883909525 81.5116090475
A/J both 188.25 23.0693812324 234.4635238434 142.0364761566
C57BL/6J both 204.8333333333 26.2656459655 257.4497448383 152.2169218284
CAST/EiJ both 172.45 28.7725735655 230.0883909525 114.8116090475
DBA/2J both 152.7 21.7500212096 196.2705281229 109.1294718771
NOD/ShiLtJ both 175.25 18.8360709004 212.9831842108 137.5168157892
PWK/PhJ both 116.175 23.0693812324 162.3885238434 69.9614761566
WSB/EiJ both 193.1 25.1147612005 243.410912281 142.789087719




  GWAS USING LINEAR MIXED MODELS