Project measure / variable:   Auwerx2   ogtt_gluc_t90_HFD

ID, description, units MPD:114594   ogtt_gluc_t90_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 90 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 90 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means166.9   mg/dL 261.9   mg/dL
Median of the strain means147.5   mg/dL 257.1   mg/dL
SD of the strain means± 57.61 ± 77.27
Coefficient of variation (CV)0.3452 0.295
Min–max range of strain means114.4   –   269.7   mg/dL 116.8   –   346.4   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 141580.4584 141580.4584 19.7111 < 0.0001
strain 7 238938.5046 34134.0721 4.7522 0.0003
sex:strain 7 82723.2481 11817.6069 1.6453 0.1418
Residuals 56 402235.5667 7182.778


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 130.4 25.657   5 11.474 0.1968 96.0, 159.0 -0.63
129S1/SvImJ m 243.0 108.9   2   77.0 0.4481 166.0, 320.0 -0.24
A/J f 158.0 30.583   4 15.292 0.1936 129.0, 193.0 -0.15
A/J m 325.4 99.43   5 44.469 0.3056 228.0, 477.0 0.82
C57BL/6J f 269.7 18.93   3 10.929 0.0702 248.0, 283.0 1.78
C57BL/6J m 341.0 74.36   4 37.18 0.2181 234.0, 406.0 1.02
CAST/EiJ f 114.4 22.534   5 10.078 0.197 79.0, 136.0 -0.91
CAST/EiJ m 263.0 31.113   2   22.0 0.1183 241.0, 285.0 0.01
DBA/2J f 120.2 28.314   5 12.663 0.2356 77.0, 156.0 -0.81
DBA/2J m 208.6 43.201   5 19.32 0.2071 159.0, 277.0 -0.69
NOD/ShiLtJ f 240.5 154.9   10 48.997 0.6442 97.0, 600.0 1.28
NOD/ShiLtJ m 251.2 94.32   5 42.183 0.3755 177.0, 401.0 -0.14
PWK/PhJ f 137.0 37.656   4 18.828 0.2749 93.0, 183.0 -0.52
PWK/PhJ m 116.8 20.105   5 8.9911 0.1721 95.0, 139.0 -1.88
WSB/EiJ f 165.0 61.21   3 35.341 0.371 112.0, 232.0 -0.03
WSB/EiJ m 346.4 111.1   5 49.698 0.3208 246.0, 490.0 1.09


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 130.4 37.9019207328 206.3266709346 54.4733290654
129S1/SvImJ m 243.0 59.9281986055 363.0506076537 122.9493923463
A/J f 158.0 42.3756356182 242.8885987575 73.1114012425
A/J m 325.4 37.9019207328 401.3266709346 249.4733290654
C57BL/6J f 269.6666666667 48.9311692625 367.6875773542 171.6457559792
C57BL/6J m 341.0 42.3756356182 425.8885987575 256.1114012425
CAST/EiJ f 114.4 37.9019207328 190.3266709346 38.4733290654
CAST/EiJ m 263.0 59.9281986055 383.0506076537 142.9493923463
DBA/2J f 120.2 37.9019207328 196.1266709346 44.2733290654
DBA/2J m 208.6 37.9019207328 284.5266709346 132.6733290654
NOD/ShiLtJ f 240.5 26.8007051702 294.1882638907 186.8117361093
NOD/ShiLtJ m 251.2 37.9019207328 327.1266709346 175.2733290654
PWK/PhJ f 137.0 42.3756356182 221.8885987575 52.1114012425
PWK/PhJ m 116.8 37.9019207328 192.7266709346 40.8733290654
WSB/EiJ f 165.0 48.9311692625 263.0209106875 66.9790893125
WSB/EiJ m 346.4 37.9019207328 422.3266709346 270.4733290654


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 186.7 35.4540004207 257.7228972889 115.6771027111
A/J both 241.7 28.4264405496 298.6450032009 184.7549967991
C57BL/6J both 305.3333333333 32.3649263071 370.1680715741 240.4985950925
CAST/EiJ both 188.7 35.4540004207 259.7228972889 117.6771027111
DBA/2J both 164.4 26.8007051702 218.0882638907 110.7117361093
NOD/ShiLtJ both 245.85 23.2100915167 292.3454004145 199.3545995855
PWK/PhJ both 126.9 28.4264405496 183.8450032009 69.9549967991
WSB/EiJ both 255.7 30.946788689 317.6938672193 193.7061327807




  GWAS USING LINEAR MIXED MODELS