Project measure / variable:   Auwerx2   ogtt_gluc_t60_HFD

ID, description, units MPD:114592   ogtt_gluc_t60_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 60 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 60 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means231.5   mg/dL 315.1   mg/dL
Median of the strain means226.6   mg/dL 316.3   mg/dL
SD of the strain means± 80.53 ± 82.04
Coefficient of variation (CV)0.3479 0.2604
Min–max range of strain means132.6   –   380.0   mg/dL 169.2   –   433.5   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 105103.6146 105103.6146 13.5705 0.0005
strain 7 362616.5152 51802.3593 6.6885 < 0.0001
sex:strain 7 67811.3146 9687.3307 1.2508 0.2915
Residuals 56 433721.6667 7745.0298


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 222.2 64.5   5 28.847 0.2903 149.0, 321.0 -0.12
129S1/SvImJ m 321.0 151.3   2   107.0 0.4714 214.0, 428.0 0.07
A/J f 231.0 47.025   4 23.512 0.2036 188.0, 277.0 -0.01
A/J m 324.2 114.2   5 51.06 0.3522 221.0, 495.0 0.11
C57BL/6J f 380.0 9.0   3 5.1962 0.0237 371.0, 389.0 1.84
C57BL/6J m 433.5 88.73   4 44.367 0.2047 315.0, 530.0 1.44
CAST/EiJ f 132.6 16.426   5 7.3457 0.1239 115.0, 152.0 -1.23
CAST/EiJ m 310.0 42.426   2   30.0 0.1369 280.0, 340.0 -0.06
DBA/2J f 159.2 23.35   5 10.442 0.1467 136.0, 188.0 -0.9
DBA/2J m 250.0 41.394   5 18.512 0.1656 204.0, 288.0 -0.79
NOD/ShiLtJ f 308.2 153.8   10 48.651 0.4992 121.0, 600.0 0.95
NOD/ShiLtJ m 311.6 99.17   5 44.348 0.3182 211.0, 453.0 -0.04
PWK/PhJ f 183.0 64.59   4 32.293 0.3529 116.0, 271.0 -0.6
PWK/PhJ m 169.2 30.557   5 13.665 0.1806 131.0, 204.0 -1.78
WSB/EiJ f 235.7 76.66   3 44.258 0.3253 162.0, 315.0 0.05
WSB/EiJ m 401.2 69.53   5 31.096 0.1733 298.0, 466.0 1.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 222.2 39.3574129279 301.0423721658 143.3576278342
129S1/SvImJ m 321.0 62.229533832 445.6607360873 196.3392639127
A/J f 231.0 44.0029253627 319.148451835 142.851548165
A/J m 324.2 39.3574129279 403.0423721658 245.3576278342
C57BL/6J f 380.0 50.8102016066 481.7850647912 278.2149352088
C57BL/6J m 433.5 44.0029253627 521.648451835 345.351548165
CAST/EiJ f 132.6 39.3574129279 211.4423721658 53.7576278342
CAST/EiJ m 310.0 62.229533832 434.6607360873 185.3392639127
DBA/2J f 159.2 39.3574129279 238.0423721658 80.3576278342
DBA/2J m 250.0 39.3574129279 328.8423721658 171.1576278342
NOD/ShiLtJ f 308.2 27.8298935713 363.9499760033 252.4500239967
NOD/ShiLtJ m 311.6 39.3574129279 390.4423721658 232.7576278342
PWK/PhJ f 183.0 44.0029253627 271.148451835 94.851548165
PWK/PhJ m 169.2 39.3574129279 248.0423721658 90.3576278342
WSB/EiJ f 235.6666666667 50.8102016066 337.4517314578 133.8816018755
WSB/EiJ m 401.2 39.3574129279 480.0423721658 322.3576278342


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 271.6 36.8154887015 345.3502860512 197.8497139488
A/J both 277.6 29.518059696 336.7317791243 218.4682208757
C57BL/6J both 406.75 33.607789379 474.0744921545 339.4255078455
CAST/EiJ both 221.3 36.8154887015 295.0502860512 147.5497139488
DBA/2J both 204.6 27.8298935713 260.3499760033 148.8500239967
NOD/ShiLtJ both 309.9 24.1013948174 358.1808954792 261.6191045208
PWK/PhJ both 176.1 29.518059696 235.2317791243 116.9682208757
WSB/EiJ both 318.4333333333 32.1351930898 382.8078606389 254.0588060277




  GWAS USING LINEAR MIXED MODELS