Project measure / variable:   Auwerx2   ogtt_gluc_t60_CD

ID, description, units MPD:114591   ogtt_gluc_t60_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 60 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 60 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means170.6   mg/dL 234.8   mg/dL
Median of the strain means168.3   mg/dL 226.3   mg/dL
SD of the strain means± 53.61 ± 70.26
Coefficient of variation (CV)0.3142 0.2993
Min–max range of strain means95.0   –   260.8   mg/dL 148.6   –   358.4   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 37462.9525 37462.9525 21.4002 < 0.0001
strain 6 166049.7924 27674.9654 15.8089 < 0.0001
sex:strain 6 66102.2279 11017.038 6.2933 < 0.0001
Residuals 52 91030.8 1750.5923


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 160.6 29.441   5 13.167 0.1833 132.0, 206.0 -0.19
129S1/SvImJ m 196.2 17.312   5 7.7421 0.0882 186.0, 227.0 -0.55
A/J f 146.8 25.074   5 11.213 0.1708 112.0, 174.0 -0.44
A/J m 253.4 48.273   5 21.588 0.1905 189.0, 323.0 0.26
C57BL/6J f 260.8 38.868   5 17.382 0.149 209.0, 292.0 1.68
C57BL/6J m 358.4 42.63   5 19.065 0.1189 313.0, 426.0 1.76
CAST/EiJ f 95.0 0.0   1   0.0 0.0 95.0, 95.0 -1.41
CAST/EiJ m 273.3 58.11   3 33.548 0.2126 209.0, 322.0 0.55
DBA/2J f 222.2 21.135   5 9.452 0.0951 198.0, 242.0 0.96
DBA/2J m 148.6 14.153   5 6.3293 0.0952 130.0, 163.0 -1.23
NOD/ShiLtJ f 176.0 34.044   3 19.655 0.1934 141.0, 209.0 0.1
NOD/ShiLtJ m 165.2 39.341   5 17.594 0.2381 129.0, 230.0 -0.99
PWK/PhJ f 118.6 7.3007   5 3.265 0.0616 108.0, 126.0 -0.97
PWK/PhJ m 199.2 20.462   5 9.151 0.1027 175.0, 230.0 -0.51
WSB/EiJ f 185.0 4.5826   3 2.6458 0.0248 180.0, 189.0 0.27
WSB/EiJ m 284.0 109.8   5 49.087 0.3865 160.0, 456.0 0.7


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 160.6 18.7114526838 198.147276746 123.052723254
129S1/SvImJ m 196.2 18.7114526838 233.747276746 158.652723254
A/J f 146.8 18.7114526838 184.347276746 109.252723254
A/J m 253.4 18.7114526838 290.947276746 215.852723254
C57BL/6J f 260.8 18.7114526838 298.347276746 223.252723254
C57BL/6J m 358.4 18.7114526838 395.947276746 320.852723254
DBA/2J f 222.2 18.7114526838 259.747276746 184.652723254
DBA/2J m 148.6 18.7114526838 186.147276746 111.052723254
NOD/ShiLtJ f 176.0 24.1563815426 224.4733258443 127.5266741557
NOD/ShiLtJ m 165.2 18.7114526838 202.747276746 127.652723254
PWK/PhJ f 118.6 18.7114526838 156.147276746 81.052723254
PWK/PhJ m 199.2 18.7114526838 236.747276746 161.652723254
WSB/EiJ f 185.0 24.1563815426 233.4733258443 136.5266741557
WSB/EiJ m 284.0 18.7114526838 321.547276746 246.452723254


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 178.4 13.2309950786 204.9499340022 151.8500659978
A/J both 200.1 13.2309950786 226.6499340022 173.5500659978
C57BL/6J both 309.6 13.2309950786 336.1499340022 283.0500659978
DBA/2J both 185.4 13.2309950786 211.9499340022 158.8500659978
NOD/ShiLtJ both 170.6 15.2778371405 201.2572230863 139.9427769137
PWK/PhJ both 158.9 13.2309950786 185.4499340022 132.3500659978
WSB/EiJ both 234.5 15.2778371405 265.1572230863 203.8427769137




  GWAS USING LINEAR MIXED MODELS