Project measure / variable:   Auwerx2   ogtt_gluc_t45_HFD

ID, description, units MPD:114590   ogtt_gluc_t45_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 45 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 45 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means266.6   mg/dL 342.2   mg/dL
Median of the strain means253.2   mg/dL 362.3   mg/dL
SD of the strain means± 92.48 ± 74.7
Coefficient of variation (CV)0.347 0.2183
Min–max range of strain means143.4   –   435.7   mg/dL 217.8   –   442.8   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 74023.5479 74023.5479 10.8334 0.0017
strain 7 363896.7125 51985.2446 7.6081 < 0.0001
sex:strain 7 87401.0258 12485.8608 1.8273 0.0999
Residuals 56 382642.0333 6832.8935


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 282.2 55.9   5 24.999 0.1981 243.0, 377.0 0.17
129S1/SvImJ m 363.0 90.51   2   64.0 0.2493 299.0, 427.0 0.28
A/J f 262.8 49.054   4 24.527 0.1867 204.0, 324.0 -0.04
A/J m 325.0 96.46   5 43.137 0.2968 228.0, 448.0 -0.23
C57BL/6J f 435.7 33.081   3 19.099 0.0759 410.0, 473.0 1.83
C57BL/6J m 442.8 36.031   4 18.016 0.0814 401.0, 484.0 1.35
CAST/EiJ f 143.4 14.977   5 6.6978 0.1044 129.0, 165.0 -1.33
CAST/EiJ m 373.5 9.1924   2   6.5 0.0246 367.0, 380.0 0.42
DBA/2J f 176.0 31.52   5 14.096 0.1791 140.0, 206.0 -0.98
DBA/2J m 253.2 86.41   5 38.644 0.3413 150.0, 380.0 -1.19
NOD/ShiLtJ f 347.1 148.9   10 47.101 0.4291 173.0, 600.0 0.87
NOD/ShiLtJ m 361.6 79.81   5 35.691 0.2207 288.0, 481.0 0.26
PWK/PhJ f 241.5 38.388   4 19.194 0.159 220.0, 299.0 -0.27
PWK/PhJ m 217.8 27.959   5 12.504 0.1284 179.0, 248.0 -1.67
WSB/EiJ f 243.7 82.14   3 47.421 0.3371 188.0, 338.0 -0.25
WSB/EiJ m 401.0 87.22   5 39.006 0.2175 283.0, 497.0 0.79


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 282.2 36.9672651203 356.2543307535 208.1456692465
129S1/SvImJ m 363.0 58.4503783238 480.0901778902 245.9098221098
A/J f 262.75 41.3306588756 345.5452587965 179.9547412035
A/J m 325.0 36.9672651203 399.0543307535 250.9456692465
C57BL/6J f 435.6666666667 47.7245340553 531.2703965742 340.0629367591
C57BL/6J m 442.75 41.3306588756 525.5452587965 359.9547412035
CAST/EiJ f 143.4 36.9672651203 217.4543307535 69.3456692465
CAST/EiJ m 373.5 58.4503783238 490.5901778902 256.4098221098
DBA/2J f 176.0 36.9672651203 250.0543307535 101.9456692465
DBA/2J m 253.2 36.9672651203 327.2543307535 179.1456692465
NOD/ShiLtJ f 347.1 26.1398038485 399.464319452 294.735680548
NOD/ShiLtJ m 361.6 36.9672651203 435.6543307535 287.5456692465
PWK/PhJ f 241.5 41.3306588756 324.2952587965 158.7047412035
PWK/PhJ m 217.8 36.9672651203 291.8543307535 143.7456692465
WSB/EiJ f 243.6666666667 47.7245340553 339.2703965742 148.0629367591
WSB/EiJ m 401.0 36.9672651203 475.0543307535 326.9456692465


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 322.6 34.5797101516 391.8714834216 253.3285165784
A/J both 293.875 27.7254488402 349.4157480651 238.3342519349
C57BL/6J both 439.2083333333 31.5668121367 502.4442567697 375.9724098969
CAST/EiJ both 258.45 34.5797101516 327.7214834216 189.1785165784
DBA/2J both 214.6 26.1398038485 266.964319452 162.235680548
NOD/ShiLtJ both 354.35 22.6377341827 399.6988308973 309.0011691027
PWK/PhJ both 229.65 27.7254488402 285.1907480651 174.1092519349
WSB/EiJ both 322.3333333333 30.183645577 382.7984411964 261.8682254702




  GWAS USING LINEAR MIXED MODELS