Project measure / variable:   Auwerx2   ogtt_gluc_t45_CD

ID, description, units MPD:114589   ogtt_gluc_t45_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 45 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 45 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means202.8   mg/dL 276.7   mg/dL
Median of the strain means195.6   mg/dL 258.5   mg/dL
SD of the strain means± 55.71 ± 85.47
Coefficient of variation (CV)0.2747 0.3089
Min–max range of strain means136.0   –   325.8   mg/dL 168.0   –   443.8   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 54216.052 54216.052 26.9755 < 0.0001
strain 6 279112.4437 46518.7406 23.1456 < 0.0001
sex:strain 6 49077.9679 8179.6613 4.0698 0.002
Residuals 52 104511.0667 2009.8282


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 212.0 48.415   5 21.652 0.2284 166.0, 282.0 0.17
129S1/SvImJ m 241.0 32.764   5 14.653 0.136 218.0, 297.0 -0.42
A/J f 168.8 35.081   5 15.689 0.2078 117.0, 208.0 -0.61
A/J m 258.4 47.062   5 21.047 0.1821 207.0, 327.0 -0.21
C57BL/6J f 325.8 32.206   5 14.403 0.0989 296.0, 378.0 2.21
C57BL/6J m 443.8 28.093   5 12.563 0.0633 417.0, 485.0 1.95
CAST/EiJ f 136.0 0.0   1   0.0 0.0 136.0, 136.0 -1.2
CAST/EiJ m 319.0 24.021   3 13.868 0.0753 300.0, 346.0 0.49
DBA/2J f 192.8 38.913   5 17.402 0.2018 139.0, 237.0 -0.18
DBA/2J m 168.0 17.804   5 7.9624 0.106 157.0, 199.0 -1.27
NOD/ShiLtJ f 212.0 44.531   3 25.71 0.2101 174.0, 261.0 0.17
NOD/ShiLtJ m 202.2 32.484   5 14.527 0.1607 175.0, 257.0 -0.87
PWK/PhJ f 176.6 48.49   5 21.685 0.2746 131.0, 257.0 -0.47
PWK/PhJ m 258.6 37.541   5 16.789 0.1452 211.0, 311.0 -0.21
WSB/EiJ f 198.3 25.325   3 14.621 0.1277 171.0, 221.0 -0.08
WSB/EiJ m 322.8 97.36   5 43.541 0.3016 172.0, 422.0 0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 212.0 20.0490808025 252.2314239368 171.7685760632
129S1/SvImJ m 241.0 20.0490808025 281.2314239368 200.7685760632
A/J f 168.8 20.0490808025 209.0314239368 128.5685760632
A/J m 258.4 20.0490808025 298.6314239368 218.1685760632
C57BL/6J f 325.8 20.0490808025 366.0314239368 285.5685760632
C57BL/6J m 443.8 20.0490808025 484.0314239368 403.5685760632
DBA/2J f 192.8 20.0490808025 233.0314239368 152.5685760632
DBA/2J m 168.0 20.0490808025 208.2314239368 127.7685760632
NOD/ShiLtJ f 212.0 25.8832520183 263.9385449671 160.0614550329
NOD/ShiLtJ m 202.2 20.0490808025 242.4314239368 161.9685760632
PWK/PhJ f 176.6 20.0490808025 216.8314239368 136.3685760632
PWK/PhJ m 258.6 20.0490808025 298.8314239368 218.3685760632
WSB/EiJ f 198.3333333333 25.8832520183 250.2718783005 146.3947883662
WSB/EiJ m 322.8 20.0490808025 363.0314239368 282.5685760632


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 226.5 14.176840992 254.9479126825 198.0520873175
A/J both 213.6 14.176840992 242.0479126825 185.1520873175
C57BL/6J both 384.8 14.176840992 413.2479126825 356.3520873175
DBA/2J both 180.4 14.176840992 208.8479126825 151.9520873175
NOD/ShiLtJ both 207.1 16.370005926 239.9488200902 174.2511799098
PWK/PhJ both 217.6 14.176840992 246.0479126825 189.1520873175
WSB/EiJ both 260.5666666667 16.370005926 293.4154867569 227.7178465764




  GWAS USING LINEAR MIXED MODELS