Project measure / variable:   Auwerx2   ogtt_gluc_t30_CD

ID, description, units MPD:114587   ogtt_gluc_t30_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 30 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 30 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means230.9   mg/dL 281.8   mg/dL
Median of the strain means217.2   mg/dL 255.2   mg/dL
SD of the strain means± 66.24 ± 76.55
Coefficient of variation (CV)0.2868 0.2716
Min–max range of strain means160.0   –   371.8   mg/dL 189.8   –   425.4   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 28101.2412 28101.2412 13.8331 0.0005
strain 6 263653.6518 43942.2753 21.631 < 0.0001
sex:strain 6 55885.7282 9314.288 4.585 0.0008
Residuals 52 105635.3333 2031.4487


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 248.4 76.72   5 34.311 0.3089 167.0, 372.0 0.26
129S1/SvImJ m 249.4 54.63   5 24.433 0.2191 192.0, 325.0 -0.42
A/J f 217.6 32.246   5 14.421 0.1482 185.0, 263.0 -0.2
A/J m 242.0 38.523   5 17.228 0.1592 185.0, 283.0 -0.52
C57BL/6J f 371.8 29.457   5 13.173 0.0792 339.0, 413.0 2.13
C57BL/6J m 425.4 46.763   5 20.913 0.1099 373.0, 470.0 1.88
CAST/EiJ f 160.0 0.0   1   0.0 0.0 160.0, 160.0 -1.07
CAST/EiJ m 261.0 32.234   3 18.61 0.1235 224.0, 283.0 -0.27
DBA/2J f 188.0 22.192   5 9.9247 0.118 165.0, 224.0 -0.65
DBA/2J m 189.8 25.074   5 11.213 0.1321 165.0, 223.0 -1.2
NOD/ShiLtJ f 262.3 46.694   3 26.959 0.178 226.0, 315.0 0.47
NOD/ShiLtJ m 240.0 37.716   5 16.867 0.1572 208.0, 291.0 -0.55
PWK/PhJ f 216.8 19.435   5 8.6914 0.0896 202.0, 248.0 -0.21
PWK/PhJ m 281.0 22.282   5 9.9649 0.0793 249.0, 302.0 -0.01
WSB/EiJ f 182.7 25.541   3 14.746 0.1398 158.0, 209.0 -0.73
WSB/EiJ m 366.2 84.41   5 37.75 0.2305 263.0, 479.0 1.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 248.4 20.1566302638 288.8472377196 207.9527622804
129S1/SvImJ m 249.4 20.1566302638 289.8472377196 208.9527622804
A/J f 217.6 20.1566302638 258.0472377196 177.1527622804
A/J m 242.0 20.1566302638 282.4472377196 201.5527622804
C57BL/6J f 371.8 20.1566302638 412.2472377196 331.3527622804
C57BL/6J m 425.4 20.1566302638 465.8472377196 384.9527622804
DBA/2J f 188.0 20.1566302638 228.4472377196 147.5527622804
DBA/2J m 189.8 20.1566302638 230.2472377196 149.3527622804
NOD/ShiLtJ f 262.3333333333 26.0220977757 314.550492696 210.1161739707
NOD/ShiLtJ m 240.0 20.1566302638 280.4472377196 199.5527622804
PWK/PhJ f 216.8 20.1566302638 257.2472377196 176.3527622804
PWK/PhJ m 281.0 20.1566302638 321.4472377196 240.5527622804
WSB/EiJ f 182.6666666667 26.0220977757 234.8838260293 130.449507304
WSB/EiJ m 366.2 20.1566302638 406.6472377196 325.7527622804


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 248.9 14.2528899454 277.5005160718 220.2994839282
A/J both 229.8 14.2528899454 258.4005160718 201.1994839282
C57BL/6J both 398.6 14.2528899454 427.2005160718 369.9994839282
DBA/2J both 188.9 14.2528899454 217.5005160718 160.2994839282
NOD/ShiLtJ both 251.1666666667 16.4578196934 284.1916979727 218.1416353607
PWK/PhJ both 248.9 14.2528899454 277.5005160718 220.2994839282
WSB/EiJ both 274.4333333333 16.4578196934 307.4583646393 241.4083020273




  GWAS USING LINEAR MIXED MODELS