Project measure / variable:   Auwerx2   ogtt_gluc_t15_HFD

ID, description, units MPD:114586   ogtt_gluc_t15_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 15 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 15 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means298.2   mg/dL 289.9   mg/dL
Median of the strain means293.6   mg/dL 279.2   mg/dL
SD of the strain means± 74.51 ± 55.97
Coefficient of variation (CV)0.2498 0.1931
Min–max range of strain means211.8   –   424.7   mg/dL 228.8   –   408.0   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1151.3451 1151.3451 0.4317 0.5138
strain 7 235011.355 33573.0507 12.5892 < 0.0001
sex:strain 7 25585.1193 3655.017 1.3706 0.2359
Residuals 56 149341.8333 2666.8185


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 244.2 38.121   5 17.048 0.1561 209.0, 305.0 -0.73
129S1/SvImJ m 245.5 51.62   2   36.5 0.2103 209.0, 282.0 -0.79
A/J f 211.8 16.958   4 8.4791 0.0801 201.0, 237.0 -1.16
A/J m 263.6 54.27   5 24.271 0.2059 200.0, 331.0 -0.47
C57BL/6J f 424.7 51.21   3 29.565 0.1206 371.0, 473.0 1.7
C57BL/6J m 408.0 18.921   4 9.4604 0.0464 382.0, 427.0 2.11
CAST/EiJ f 277.0 24.062   5 10.761 0.0869 250.0, 312.0 -0.28
CAST/EiJ m 267.5 53.03   2   37.5 0.1983 230.0, 305.0 -0.4
DBA/2J f 218.6 31.037   5 13.88 0.142 183.0, 251.0 -1.07
DBA/2J m 228.8 42.564   5 19.035 0.186 178.0, 277.0 -1.09
NOD/ShiLtJ f 361.0 95.85   10 30.31 0.2655 253.0, 600.0 0.84
NOD/ShiLtJ m 291.0 31.081   5 13.9 0.1068 246.0, 333.0 0.02
PWK/PhJ f 338.2 65.66   4 32.831 0.1941 293.0, 433.0 0.54
PWK/PhJ m 291.6 28.148   5 12.588 0.0965 245.0, 321.0 0.03
WSB/EiJ f 310.3 9.609   3 5.5478 0.031 300.0, 319.0 0.16
WSB/EiJ m 322.8 26.65   5 11.918 0.0826 281.0, 349.0 0.59


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 244.2 23.0946680097 290.4641793452 197.9358206548
129S1/SvImJ m 245.5 36.515876358 318.6500904047 172.3499095953
A/J f 211.75 25.8206237937 263.4749249696 160.0250750304
A/J m 263.6 23.0946680097 309.8641793452 217.3358206548
C57BL/6J f 424.6666666667 29.8150881959 484.3934653767 364.9398679567
C57BL/6J m 408.0 25.8206237937 459.7249249696 356.2750750304
CAST/EiJ f 277.0 23.0946680097 323.2641793452 230.7358206548
CAST/EiJ m 267.5 36.515876358 340.6500904047 194.3499095953
DBA/2J f 218.6 23.0946680097 264.8641793452 172.3358206548
DBA/2J m 228.8 23.0946680097 275.0641793452 182.5358206548
NOD/ShiLtJ f 361.0 16.3303963589 393.713714941 328.286285059
NOD/ShiLtJ m 291.0 23.0946680097 337.2641793452 244.7358206548
PWK/PhJ f 338.25 25.8206237937 389.9749249696 286.5250750304
PWK/PhJ m 291.6 23.0946680097 337.8641793452 245.3358206548
WSB/EiJ f 310.3333333333 29.8150881959 370.0601320433 250.6065346233
WSB/EiJ m 322.8 23.0946680097 369.0641793452 276.5358206548


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 244.85 21.6030837884 288.1261770975 201.5738229025
A/J both 237.675 17.3210010072 272.3731345089 202.9768654911
C57BL/6J both 416.3333333333 19.7208271709 455.8388973315 376.8277693352
CAST/EiJ both 272.25 21.6030837884 315.5261770975 228.9738229025
DBA/2J both 223.7 16.3303963589 256.413714941 190.986285059
NOD/ShiLtJ both 326.0 14.1425381007 354.3309081911 297.6690918089
PWK/PhJ both 314.925 17.3210010072 349.6231345089 280.2268654911
WSB/EiJ both 316.5666666667 18.8567174675 354.3412109215 278.7921224119




  GWAS USING LINEAR MIXED MODELS